Search Results - "Cowart, L. Ashley"

Sphingolipids in metabolic disease: The good, the bad, and the unknown by Green, Christopher D., Maceyka, Michael, Cowart, L. Ashley, Spiegel, Sarah

“…The bioactive sphingolipid metabolites ceramide and sphingosine-1-phosphate (S1P) are a recent addition to the lipids accumulated in obesity and have emerged…”
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Lipotoxic very‐long‐chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes by Law, Brittany A., Liao, Xianghai, Moore, Kelsey S., Southard, Abigail, Roddy, Patrick, Ji, Ruiping, Szulc, Zdzislaw, Bielawska, Ala, Schulze, P. Christian, Cowart, L. Ashley

“…Accumulating data support a role for bioactive lipids as mediators of lipotixicity in cardiomyocytes. One class of these, the ceramides, constitutes a family…”
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Sphingolipids: players in the pathology of metabolic disease by Cowart, L. Ashley

“…The contribution of aberrant production of bioactive lipids to pathophysiological changes associated with obesity has risen to the forefront of lipid research…”
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FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice by Rohrbach, Timothy D., Asgharpour, Amon, Maczis, Melissa A., Montefusco, David, Cowart, L. Ashley, Bedossa, Pierre, Sanyal, Arun J., Spiegel, Sarah

“…Nonalcoholic fatty liver disease (NAFLD), a leading cause of liver dysfunction, is a metabolic disease that begins with steatosis. Sphingolipid metabolites,…”
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Farnesoid X receptor prevents neutrophil extracellular traps via reduced sphingosine-1-phosphate in chronic kidney disease by Jones, Bryce A, Myakala, Komuraiah, Guha, Mahilan, Davidson, Shania, Adapa, Sharmila, Lopez Santiago, Isabel, Schaffer, Isabel, Yue, Yang, Allegood, Jeremy C, Cowart, L Ashley, Wang, Xiaoxin X, Rosenberg, Avi Z, Levi, Moshe

“…Farnesoid X receptor (FXR) activation reduces renal inflammation, but the underlying mechanisms remain elusive. Neutrophil extracellular traps (NETs) are webs…”
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Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease by Anderson, Andrea K., Lambert, Johana M., Montefusco, David J., Tran, Bao Ngan, Roddy, Patrick, Holland, William L., Cowart, L. Ashley

“…Sphingolipids have become established participants in the pathogenesis of obesity and its associated maladies. Sphingosine kinase 1 (SPHK1), which generates…”
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Dynamic changes in the mouse hepatic lipidome following warm ischemia reperfusion injury by Liss, Kim H. H., Mousa, Muhammad, Bucha, Shria, Lutkewitte, Andrew, Allegood, Jeremy, Cowart, L. Ashley, Finck, Brian N.

“…Liver failure secondary to metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common cause for liver transplantation in many…”
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Docosahexaenoic acid antagonizes the boosting effect of palmitic acid on LPS inflammatory signaling by inhibiting gene transcription and ceramide synthesis by Jin, Junfei, Lu, Zhongyang, Li, Yanchun, Cowart, L Ashley, Lopes-Virella, Maria F, Huang, Yan

“…It is well known that saturated fatty acids (SFAs) and unsaturated fatty acid, in particular omega-3 polyunsaturated fatty acids (n-3 PUFAs), have different…”
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Sphingolipid Mediators of Myocardial Pathology by Kovilakath, Anna, Cowart, L Ashley

“…Cardiomyopathy is the leading cause of mortality worldwide. While the causes of cardiomyopathy continue to be elucidated, current evidence suggests that…”
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Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages by Jin, Junfei, Zhang, Xiaoming, Lu, Zhongyang, Perry, David M, Li, Yanchun, Russo, Sarah Brice, Cowart, L Ashley, Hannun, Yusuf A, Huang, Yan

“…Periodontal disease is more prevalent and severe in patients with diabetes than in nondiabetic patients. In addition to diabetes, a large number of studies…”
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Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis by Rachidi, Saleh, Sun, Shaoli, Wu, Bill X, Jones, Elizabeth, Drake, Richard R, Ogretmen, Besim, Cowart, L. Ashley, Clarke, Christopher J, Hannun, Yusuf A, Chiosis, Gabriela, Liu, Bei, Li, Zihai

“…Graphical abstract…”
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Circulating sphingolipids in heart failure by Kovilakath, Anna, Wohlford, George, Cowart, L Ashley

“…Lack of significant advancements in early detection and treatment of heart failure have precipitated the need for discovery of novel biomarkers and therapeutic…”
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Systemic Elevation of n-3 Polyunsaturated Fatty Acids (n-3-PUFA) Is Associated with Protection against Visual, Motor, and Emotional Deficits in Mice following Closed-Head Mild Traumatic Brain Injury by Mondal, Koushik, Takahashi, Haruka, Cole, Jerome, Del Mar, Nobel A., Li, Chunyan, Stephenson, Daniel J., Allegood, Jeremy, Cowart, L. Ashley, Chalfant, Charles E., Reiner, Anton, Mandal, Nawajes

“…Traumatic brain injury (TBI) causes neuroinflammation and neurodegeneration leading to various pathological complications such as motor and sensory (visual)…”
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Sphingosine kinase 1 mediates sexual dimorphism in fibrosis in a mouse model of NASH by Montefusco, David, Jamil, Maryam, Maczis, Melissa A., Schroeder, William, Levi, Moshe, Ranjit, Suman, Allegood, Jeremy, Bandyopadhyay, Dipankar, Retnam, Reuben, Spiegel, Sarah, Cowart, L. Ashley

“…Men with non-alcoholic fatty liver disease (NAFLD) are more likely to progress to non-alcoholic steatohepatitis (NASH) and liver fibrosis than women. However,…”
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Erratum: FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice by Rohrbach, Timothy D., Asgharpour, Amon, Maczis, Melissa A., Montefusco, David, Cowart, L. Ashley, Bedossa, Pierre, Sanyal, Arun J., Spiegel, Sarah

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Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes by Russo, Sarah Brice, Baicu, Catalin F, Van Laer, An, Geng, Tuoyu, Kasiganesan, Harinath, Zile, Michael R, Cowart, L Ashley

“…Diabetic cardiomyopathy (DbCM), which consists of cardiac hypertrophy and failure in the absence of traditional risk factors, is a major contributor to…”
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Selective Substrate Supply in the Regulation of Yeast de Novo Sphingolipid Synthesis by Cowart, L. Ashley, Hannun, Yusuf A.

“…The heat stress response of Saccharomyces cerevisiae is characterized by transient cell cycle arrest, altered gene expression, degradation of nutrient…”
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Control of Plasma Membrane Permeability by ABC Transporters by Khakhina, Svetlana, Johnson, Soraya S, Manoharlal, Raman, Russo, Sarah B, Blugeon, Corinne, Lemoine, Sophie, Sunshine, Anna B, Dunham, Maitreya J, Cowart, L Ashley, Devaux, Frédéric, Moye-Rowley, W Scott

“…ATP-binding cassette transporters Pdr5 and Yor1 from Saccharomyces cerevisiae control the asymmetric distribution of phospholipids across the plasma membrane…”
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Sphingolipids mediate formation of mRNA processing bodies during the heat-stress response of Saccharomyces cerevisiae by Cowart, L Ashley, Gandy, Jason L, Tholanikunnel, Baby, Hannun, Yusuf A

“…Recent work, especially in the yeast Saccharomyces cerevisiae, has demonstrated that mRNA movement from active translation to cytoplasmic granules, termed…”
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Transglutaminase 2 knockout mice are protected from bleomycin‐induced lung fibrosis with preserved lung function and reduced metabolic derangements by Freeberg, Margaret A. T., Thatcher, Thomas H., Camus, Sarah V., Huang, Linghong, Atkinson, John, Narrow, Wade, Haak, Jeannie, Dylag, Andrew M., Cowart, L. Ashley, Johnson, Timothy S., Sime, Patricia J.

“…Pulmonary fibrosis is an interstitial scarring disease of the lung characterized by poor prognosis and limited treatment options. Tissue transglutaminase 2…”
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