Search Results - "Cowart, L. A."

Fatty acids differentially regulate insulin resistance through endoplasm reticulum stress-mediated induction of tribbles homologue 3: a potential link between dietary fat composition and the pathophysiological outcomes of obesity by Geng, T., Hu, W., Broadwater, M. H., Snider, J. M., Bielawski, J., Russo, S. B., Schwacke, J. H., Ross, J., Cowart, L. A.

“…Aims/hypothesis Previous studies have shown that saturated fatty acids cause insulin resistance (IR) that is prevented by unsaturated fatty acids. Tribbles…”
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Sphingolipids in obesity, type 2 diabetes, and metabolic disease by Russo, S B, Ross, J S, Cowart, L A

“…Metabolic disease, including obesity and type 2 diabetes, constitutes a major emerging health crisis in Western nations. Although the symptoms and clinical…”
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Abstract 19536: Lipid Oversupply to Cardiomyocytes Induces Sphingolipid-dependent Oxidative Stress and Induction of Mitophagy Through Ceramide Synthase 2 by Law, Brittany A, Roddy, Patrick, Liao, Xianghai, Schulze, P C, Cowart, L A

“…IntroductionDiabetic cardiomyopathy (DbCM) contributes to the high risk of heart failure (HF) in diabetics, but mechanisms underlying DbCM remain unclear. We…”
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Using genomic and lipidomic strategies to investigate sphingolipid function in the yeast heat-stress response by Cowart, L A, Hannun, Y A

“…In addition to their crucial role in membrane structure in Saccharomyces cerevisiae, sphingolipids serve vital roles in various aspects of yeast biology…”
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Structural Determinants of Active Site Binding Affinity and Metabolism by Cytochrome P450 BM-3 by Cowart, L.Ashley, Falck, John R., Capdevila, Jorge H.

“…The determinants of the regio- and stereoselective oxidation of fatty acids by cytochrome P450 BM-3 were examined by mutagenesis of residues postulated to…”
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Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae by Alvarez-Vasquez, F, Sims, K.J, Cowart, L.A, Okamoto, Y, Voit, E.O, Hannun, Y.A

“…Mathematical models have become a necessary tool for organizing the rapidly increasing amounts of large-scale data on biochemical pathways and for advanced…”
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The CYP4A Isoforms Hydroxylate Epoxyeicosatrienoic Acids to Form High Affinity Peroxisome Proliferator-activated Receptor Ligands by Cowart, L Ashley, Wei, Shouzuo, Hsu, Mei-Hui, Johnson, Eric F, Krishna, Murali U, Falck, John R, Capdevila, Jorge H

“…Cytochromes P450 of the CYP2C and CYP4A gene subfamilies metabolize arachidonic acid to 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (EETs) and to…”
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Distinct roles for de novo versus hydrolytic pathways of sphingolipid biosynthesis in Saccharomyces cerevisiae by Cowart, L Ashley, Okamoto, Yasuo, Lu, Xinghua, Hannun, Yusuf A

“…Saccharomyces cerevisiae produces the sphingolipid ceramide by de novo synthesis as well as by hydrolysis of complex sphingolipids by Isc1p…”
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Acute Activation of de Novo Sphingolipid Biosynthesis upon Heat Shock Causes an Accumulation of Ceramide and Subsequent Dephosphorylation of SR Proteins by Jenkins, Gary M, Cowart, L Ashley, Signorelli, Paola, Pettus, Benjamin J, Chalfant, Charles E, Hannun, Yusuf A

“…Recent studies are beginning to implicate sphingolipids in the heat stress response. In the yeast Saccharomyces cerevisiae , heat stress has been shown to…”
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Structural determinants of sphingolipid recognition by commercially available anti-ceramide antibodies by Cowart, L Ashley, Szulc, Zdzislaw, Bielawska, Alicja, Hannun, Yusuf A

“…The sphingolipid mediator ceramide is involved in cellular processes such as apoptosis, differentiation, responses to cytokines, and stress responses…”
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Roles for Sphingolipid Biosynthesis in Mediation of Specific Programs of the Heat Stress Response Determined through Gene Expression Profiling by Cowart, L.Ashley, Okamoto, Yasuo, Pinto, Francisco R., Gandy, Jason L., Almeida, Jonas S., Hannun, Yusuf A.

“…Previous studies have demonstrated roles for de novo production of sphingolipids in Saccharomyces cerevisiae in the regulation of the transient cell cycle…”
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Local correlation of expression profiles with gene annotations—proof of concept for a general conciliatory method by Pinto, F. R., Cowart, L. Ashley, Hannun, Yusuf A., Rohrer, B., Almeida, J. S.

“…Motivation: Integrated analysis of expression data and gene ontology annotations is a prime example of biological data that need co-explanatory interpretation…”
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