Search Results - "Coward, Eivind"
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Monitoring multiple myeloma by quantification of recurrent mutations in serum
Published in Haematologica (Roma) (01-07-2017)“…Circulating tumor DNA is a promising biomarker to monitor tumor load and genome alterations. We explored the presence of circulating tumor DNA in multiple…”
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2
Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study
Published in Nature communications (20-04-2023)“…Appendicular lean mass (ALM) associates with mobility and bone mineral density (BMD). While associations between gut microbiota composition and ALM have been…”
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3
Mutational analysis and protein profiling predict drug sensitivity in multiple myeloma cell lines
Published in Frontiers in oncology (29-11-2022)“…Multiple myeloma (MM) is a heterogeneous disease where cancer-driver mutations and aberrant signaling may lead to disease progression and drug resistance. Drug…”
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4
Transplantation of gut microbiota from old mice into young healthy mice reduces lean mass but not bone mass
Published in Gut microbes (2023)“…Aging is associated with low bone and lean mass as well as alterations in the gut microbiota (GM). In this study, we determined whether the reduced bone mass…”
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5
VOLIN and KJON-Two novel hyperdiploid myeloma cell lines
Published in Genes chromosomes & cancer (01-11-2016)“…Multiple myeloma can be divided into two distinct genetic subgroups: hyperdiploid (HRD) or nonhyperdiploid (NHRD) myeloma. Myeloma cell lines are important…”
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6
Selection in the host structures the microbiota associated with developing cod larvae (Gadus morhua)
Published in Environmental microbiology (01-10-2015)“…Summary Marine fish larvae are immature upon hatching, and share their environment with high numbers of bacteria. The microbial communities associated with…”
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7
Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence
Published in Leukemia (01-07-2022)“…We investigated genomic and transcriptomic changes in paired tumor samples of 29 in-house multiple myeloma (MM) patients and 28 patients from the MMRF CoMMpass…”
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High SHBGand low bioavailable testosterone are strongly causally associated with increased forearm fracture risk in women: an MR study leveraging novel female-specific data
Published in Calcified tissue international (2024)“…The effects of androgens on women’s bone health are not fully understood. Mendelian randomization (MR) studies using sex-combined data suggest that sex…”
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High SHBG and Low Bioavailable Testosterone are Strongly Causally Associated with Increased Forearm Fracture Risk in Women: An MR Study Leveraging Novel Female-Specific Data
Published in Calcified tissue international (01-11-2024)“…The effects of androgens on women’s bone health are not fully understood. Mendelian randomization (MR) studies using sex-combined data suggest that sex…”
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10
Cross-sectional associations between the gut microbe Ruminococcus gnavus and features of the metabolic syndrome
Published in The lancet. Diabetes & endocrinology (01-07-2022)Get full text
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11
Large-scale circulating proteome association study (CPAS) meta-analysis identifies circulating proteins and pathways predicting incident hip fractures
Published in Journal of bone and mineral research (22-03-2024)“…Hip fractures are associated with significant disability, high cost, and mortality. However, the exact biological mechanisms underlying susceptibility to hip…”
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Cross-sectional associations between the gut microbe Ruminococcus gnavus and features of the metabolic syndrome: the HUNT study
Published in The lancet. Diabetes & endocrinology (01-07-2022)Get full text
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13
Whole-Exome and mRNA Sequencing of Multiple Myeloma Reveal Transformation to a More High-Risk and Proliferative Tumor at Relapse
Published in Blood (29-11-2018)“…Introduction Multiple myeloma (MM) is a malignant plasma cell disorder of which the prognosis has significantly improved since the introduction of proteasome…”
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Identification of three bacteria species associated with increased lean mass – The HUNT study
Published in Bone Reports (01-05-2022)Get full text
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15
An atlas of genetic determinants of forearm fracture
Published in Nature genetics (2023)“…Osteoporotic fracture is among the most common and costly of diseases. While reasonably heritable, its genetic determinants have remained elusive. Forearm…”
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Detection and Monitoring of BRAF and NRAS Mutant Clones in Myeloma Patients By Digital PCR of Circulating DNA
Published in Blood (03-12-2015)“…Introduction Targeted mutation specific therapy is a promising approach in cancer therapy. However, an obstacle for this approach is the vast heterogeneity of…”
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The HUNT study: A population-based cohort for genetic research
Published in Cell genomics (12-10-2022)“…The Trøndelag Health Study (HUNT) is a population-based cohort of ∼229,000 individuals recruited in four waves beginning in 1984 in Trøndelag County, Norway…”
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Assessment of the genetic and clinical determinants of hip fracture risk: Genome-wide association and Mendelian randomization study
Published in Cell reports. Medicine (18-10-2022)“…Hip fracture is the clinically most important fracture, but the genetic architecture of hip fracture is unclear. Here, we perform a large-scale hip fracture…”
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19
Stability and uniqueness of clonal immunoglobulin CDR3 sequences for MRD tracking in multiple myeloma
Published in American journal of hematology (01-12-2019)“…Minimal residual disease (MRD) tracking, by next generation sequencing of immunoglobulin sequences, is moving towards clinical implementation in multiple…”
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Publisher Correction: A plasma protein-based risk score to predict hip fractures
Published in Nature aging (01-10-2024)Get full text
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