Search Results - "Cowan, Kenneth H"

Correction: ERK1/2 Signaling Plays an Important Role in Topoisomerase II Poison-Induced G2/M Checkpoint Activation by Kolb, Ryan H, Greer, Patrick M, Cao, Phu T, Cowan, Kenneth H, Yan, Ying

“…For the Fig 6A ETOP ATR activity panel, 6B ATR activity panel, and 6C DOX Chk2 activity panel, only the cropped images are available; however, the authors’…”
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Exome analysis reveals differentially mutated gene signatures of stage, grade and subtype in breast cancers by Li, You, Wang, Xiaosheng, Vural, Suleyman, Mishra, Nitish K, Cowan, Kenneth H, Guda, Chittibabu

“…Breast cancers exhibit highly heterogeneous molecular profiles. Although gene expression profiles have been used to predict the risks and prognostic outcomes…”
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ERK1/2 signaling plays an important role in topoisomerase II poison-induced G2/M checkpoint activation by Kolb, Ryan H, Greer, Patrick M, Cao, Phu T, Cowan, Kenneth H, Yan, Ying

“…Topo II poisons, which target topoisomerase II (topo II) to generate enzyme mediated DNA damage, have been commonly used for anti-cancer treatment. While…”
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KSR1 Is Required for Cell Cycle Reinitiation Following DNA Damage by Razidlo, Gina L., Johnson, Heidi J., Stoeger, Scott M., Cowan, Kenneth H., Bessho, Tadayoshi, Lewis, Robert E.

“…KSR1 (kinase suppressor of Ras 1) is a molecular scaffold and positive regulator of the Raf/MEK/ERK phosphorylation cascade. KSR1 is required for maximal ERK…”
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Heregulin-Dependent Delay in Mitotic Progression Requires HER4 and BRCA1 by Muraoka-Cook, Rebecca S., Caskey, Laura S., Sandahl, Melissa A., Hunter, Debra M., Husted, Carty, Strunk, Karen E., Sartor, Carolyn I., Rearick, William A., McCall, Wesley, Sgagias, Magdalene K., Cowan, Kenneth H., Earp, H. Shelton

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Breast Cancer Collaborative Registry informs understanding of factors predicting sleep quality by Berger, Ann M., Kupzyk, Kevin A., Djalilova, Dilorom M., Cowan, Kenneth H.

“…Significance Poor sleep quality is a common and persistent problem reported by women with breast cancer (BC). Empirical evidence identifies many risk factors…”
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Receptor for hyaluronan‐mediated motility (RHAMM) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patients by Tarullo, Sarah E, He, Yuyu, Daughters, Claire, Knutson, Todd P, Henzler, Christine M, Price, Matthew A, Shanley, Ryan, Witschen, Patrice, Tolg, Cornelia, Kaspar, Rachael E, Hallstrom, Caroline, Gittsovich, Lyubov, Sulciner, Megan L, Zhang, Xihong, Forster, Colleen L, Lange, Carol A, Shats, Oleg, Desler, Michelle, Cowan, Kenneth H, Yee, Douglas, Schwertfeger, Kathryn L, Turley, Eva A, McCarthy, James B, Nelson, Andrew C

“…Breast cancer invasion and metastasis result from a complex interplay between tumor cells and the tumor microenvironment (TME). Key oncogenic changes in the…”
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Withdrawal: BRCA1-induced apoptosis involves inactivation of ERK1/2 activities by Yan, Ying, Haas, John P., Kim, Min, Sgagias, Magdalene K., Cowan, Kenneth H.

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Ectopic expression of von Hippel–Lindau tumor suppressor induces apoptosis in 786-O renal cell carcinoma cells and regresses tumor growth of 786-O cells in nude mouse by Kim, Min, Yan, Ying, Lee, Kwangmoon, Sgagias, Magda, Cowan, Kenneth H

“…The von Hippel–Lindau (VHL) is a known tumor suppressor that binds to α-subunits of hypoxia-inducible factors and induces ubiquitin-mediated degradation of the…”
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Brca1-Deficient Murine Mammary Epithelial Cells have Increased Sensitivity to CDDP and MMS by Sgagias, Magdalene K., Wagner, Kay-Uwe, Hamik, Brad, Stoeger, Scott, Spieker, Rebecca, Huber, L. Julie, Chodosh, Lewis A., Cowan, Kenneth H.

“…In this report we describe the isolation of an isogenic pair of Brca1+/+ and Brca1-/-murine mammary epithelial cells (MMECs). These cells were isolated from…”
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BRCA1-induced Apoptosis Involves Inactivation of ERK1/2 Activities by Yan, Ying, Haas, John P., Kim, Min, Sgagias, Magdalene K., Cowan, Kenneth H.

“…Mutation in the BRCA1 gene is associated with an increased risk of breast and ovarian cancer. Recent studies have shown that the BRCA1 gene product may be…”
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Correction: KSR1 is required for cell cycle reinitiation following DNA damage by Razidlo, Gina L., Johnson, Heidi J., Stoeger, Scott M., Cowan, Kenneth H., Bessho, Tadayoshi, Lewis, Robert E.

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The combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2L) and Genistein is effective in inhibiting pancreatic cancer growth by Nozawa, Fumiaki, Itami, Atsushi, Saruc, Murat, Kim, Min, Standop, Jens, Picha, Kathleen S, Cowan, Kenneth H, Pour, Parviz M

“…Our previous studies have shown that, contrary to many other human pancreatic adenocarcinoma cell lines, AsPC1 cells are resistant to the apoptotic effect of…”
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BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage by Brody, Lawrence C, Yarden, Ronit I, Pardo-Reoyo, Sherly, Sgagias, Magda, Cowan, Kenneth H

“…The breast cancer tumor-suppressor gene, BRCA1, encodes a protein with a BRCT domain-a motif that is found in many proteins that are implicated in DNA damage…”
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Phase I Clinical Trial of Alitretinoin and Tamoxifen in Breast Cancer Patients: Toxicity, Pharmacokinetic, and Biomarker Evaluations by LAWRENCE, Julia A, ADAMSON, Peter C, COWAN, Kenneth H, KAISER, Muriel, O'SHAUGHNESSY, Joyce, ZUJEWSKI, Joanne, CARUSO, Rafael, CHOW, Catherine, KLEINER, David, MURPHY, Robert F, VENZON, David J, SHOVLIN, Margaret, NOONE, Marianne, MERINO, Maria

“…To determine the overall and dose-limiting toxicities (DLTs) of alitretinoin (9-cis-retinoic acid) in combination with tamoxifen and the pharmacokinetics of…”
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Correction: Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation by Yan, Ying, Hein, Ashley L, Etekpo, Asserewou, Burchett, Katrina M, Lin, Chi, Enke, Charles A, Batra, Surinder K, Cowan, Kenneth H, Ouellette, Michel M

“…[This corrects the article DOI: 10.18632/oncotarget.2500.]…”
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Breast Cancer Risk Reduction, Version 2.2015 by Bevers, Therese B, Ward, John H, Arun, Banu K, Colditz, Graham A, Cowan, Kenneth H, Daly, Mary B, Garber, Judy E, Gemignani, Mary L, Gradishar, William J, Jordan, Judith A, Korde, Larissa A, Kounalakis, Nicole, Krontiras, Helen, Kumar, Shicha, Kurian, Allison, Laronga, Christine, Layman, Rachel M, Loftus, Loretta S, Mahoney, Martin C, Merajver, Sofia D, Meszoely, Ingrid M, Mortimer, Joanne, Newman, Lisa, Pritchard, Elizabeth, Pruthi, Sandhya, Seewaldt, Victoria, Specht, Michelle C, Visvanathan, Kala, Wallace, Anne, Bergman, Mary Ann, Kumar, Rashmi

“…Breast cancer is the most frequently diagnosed malignancy in women in the United States and is second only to lung cancer as a cause of cancer death. To assist…”
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Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation by Yan, Ying, Hein, Ashley L, Etekpo, Asserewou, Burchett, Katrina M, Lin, Chi, Enke, Charles A, Batra, Surinder K, Cowan, Kenneth H, Ouellette, Michel M

“…Radiation therapy is a staple treatment for pancreatic cancer. However, owing to the intrinsic radioresistance of pancreatic cancer cells, radiation therapy…”
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Distinct Neoadjuvant Chemotherapy Response and 5-Year Outcome in Patients With Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Breast Tumors That Reclassify as Basal-Type by the 80-Gene Signature by Whitworth, Pat W, Beitsch, Peter D, Pellicane, James V, Baron, Paul L, Lee, Laura A, Dul, Carrie L, Murray, Mary K, Gittleman, Mark A, Budway, Raye J, Rahman, Rakhshanda Layeequr, Kelemen, Pond R, Dooley, William C, Rock, David T, Cowan, Kenneth H, Lesnikoski, Beth-Ann, Barone, Julie L, Ashikari, Andrew Y, Dupree, Beth B, Wang, Shiyu, Menicucci, Andrea R, Yoder, Erin B, Finn, Christine, Corcoran, Kate, Blumencranz, Lisa E, Audeh, William

“…The 80-gene molecular subtyping signature (80-GS) reclassifies a proportion of immunohistochemistry (IHC)-defined luminal breast cancers (estrogen…”
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Two PALB2 germline mutations found in both BRCA1+ and BRCAx familial breast cancer by Downs, Bradley, Kim, Yeong C., Xiao, Fengxia, Snyder, Carrie, Chen, Peixian, Fleissner, Elizabeth A., Becirovic, Dina, Wen, Hongxiu, Sherman, Simon, Cowan, Kenneth H., Lynch, Henry T., Wang, San Ming

“…Partner and localizer of BRCA2 (PALB2), plays an important functional role in DNA damage repair. Recent studies indicate that germline mutations in PALB2…”
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