Search Results - "Cowan, Joanne L"

SLiMPrints: conservation-based discovery of functional motif fingerprints in intrinsically disordered protein regions by Davey, Norman E, Cowan, Joanne L, Shields, Denis C, Gibson, Toby J, Coldwell, Mark J, Edwards, Richard J

“…Large portions of higher eukaryotic proteomes are intrinsically disordered, and abundant evidence suggests that these unstructured regions of proteins are rich…”
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ABC50 mutants modify translation start codon selection by Stewart, Joanna D, Cowan, Joanne L, Perry, Lisa S, Coldwell, Mark J, Proud, Christopher G

“…ATP-binding cassette 50 (ABC50; also known as ABCF1) binds to eukaryotic initiation factor 2 (eIF2) and is required for efficient translation initiation. An…”
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G-quadruplexes mediate local translation in neurons by Schofield, James P R, Cowan, Joanne L, Coldwell, Mark J

“…There has recently been a huge increase in interest in the formation of stable G-quadruplex structures in mRNAs and their functional significance. In neurons,…”
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Multiple isoforms of the translation initiation factor eIF4GII are generated via use of alternative promoters, splice sites and a non-canonical initiation codon by Coldwell, Mark J, Sack, Ulrike, Cowan, Joanne L, Barrett, Rachel M, Vlasak, Markete, Sivakumaran, Keiley, Morley, Simon J

“…During the initiation stage of eukaryotic mRNA translation, the eIF4G (eukaryotic initiation factor 4G) proteins act as an aggregation point for recruiting the…”
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Phosphorylation of eIF4GII and 4E-BP1 in response to nocodazole treatment: A reappraisal of translation initiation during mitosis by Coldwell, Mark, Cowan, Joanne, Vlasak, Markete, Mead, Abbie, Willett, Mark, Perry, Lisa, Morley, Simon

“…Translation mechanisms at different stages of the cell cycle have been studied for many years, resulting in the dogma that translation rates are slowed during…”
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mTORCing about myogenic differentiation by Iadevaia, Valentina, Cowan, Joanne L, Coldwell, Mark J

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Inhibition of mammalian target of rapamycin (mTOR) signalling in C2C12 myoblasts prevents myogenic differentiation without affecting the hyperphosphorylation of 4E-BP1 by Willett, Mark, Cowan, Joanne L., Vlasak, Markete, Coldwell, Mark J., Morley, Simon J.

“…Current accepted models suggest that hypophosphorylated 4E-binding protein (4E-BP1) binds to initiation factor 4E (eIF4E) to inhibit cap-dependent translation,…”
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The proteasome inhibitor, MG132, promotes the reprogramming of translation in C2C12 myoblasts and facilitates the association of hsp25 with the eIF4F complex by Cowan, Joanne L., Morley, Simon J.

“…The eukaryotic translation initiation factor (eIF) 4E, is regulated by modulating both its phosphorylation and its availability to interact with the scaffold…”
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