Search Results - "Cowan, J O"

Predicting steroid responsiveness in patients with asthma using exhaled breath profiling by van der Schee, M. P., Palmay, R., Cowan, J. O., Taylor, D. R.

“…Summary Background Exhaled breath contains disease‐dependent volatile organic compounds (VOCs), which may serve as biomarkers distinguishing clinical…”
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The effect of adiposity measured by dual-energy X-ray absorptiometry on lung function by Sutherland, T. J. T, Goulding, A, Grant, A. M, Cowan, J. O, Williamson, A, Williams, S. M, Skinner, M. A, Taylor, D. R

“…Respiratory function is impaired in obesity but there are limitations with body mass index and skin-fold thickness in assessing this effect. The present…”
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Exhaled NO and assessment of anti-inflammatory effects of inhaled steroid: dose-response relationship by Jones, S.L, Herbison, P, Cowan, J.O, Flannery, E.M, Hancox, R.J, McLachlan, C.R, Taylor, D.R

“…Exhaled nitric oxide (eNO) is an easily measured marker of airway inflammation. This study was undertaken to evaluate the usefulness of serial eNO in…”
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Effects of steroid therapy on inflammatory cell subtypes in asthma by Cowan, Douglas C, Cowan, Jan O, Palmay, Rochelle, Williamson, Avis, Taylor, D Robin

“…RATIONALE Airway inflammation in asthma is heterogeneous with different phenotypes. The inflammatory cell phenotype is modified by corticosteroids and smoking…”
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Bronchodilator tolerance: the impact of increasing bronchoconstriction by Wraight, J.M, Hancox, R.J, Herbison, G.P, Cowan, J.O, Flannery, E.M, Taylor, D.R

“…Chronic exposure to beta-agonists causes tolerance to their bronchodilator effects, which is best demonstrated during acute bronchoconstriction. The aim of the…”
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Relationship between socioeconomic status and asthma: a longitudinal cohort study by Hancox, R J, Milne, B J, Taylor, D R, Greene, J M, Cowan, J O, Flannery, E M, Herbison, G P, McLachlan, C R, Poulton, R, Sears, M R

“…Background: There is conflicting information about the relationship between asthma and socioeconomic status, with different studies reporting no, positive, or…”
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Tolerance to beta-agonists during acute bronchoconstriction by Hancox, RJ, Aldridge, RE, Cowan, JO, Flannery, EM, Herbison, GP, McLachlan, CR, Town, GI, Taylor, DR

“…Previous reports suggest that regular use of β‐agonists does not lead to tolerance to their bronchodilator effects. However, most studies have been conducted…”
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Reversing acute bronchoconstriction in asthma: the effect of bronchodilator tolerance after treatment with formoterol by Jones, S.L, Cowan, J.O, Flannery, E.M, Hancox, R.J, Herbison, G.P, Taylor, D.R

“…Continuous treatment with a short-acting beta2-agonist can lead to reduced bronchodilator responsiveness during acute bronchoconstriction. This study evaluated…”
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Simvastatin in the treatment of asthma: lack of steroid-sparing effect by Cowan, Douglas C, Cowan, Jan O, Palmay, Rochelle, Williamson, Avis, Taylor, D Robin

“…Statins have anti-inflammatory actions which in theory are potentially beneficial in asthma. Small trials have failed to show a significant benefit, but a…”
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Bronchodilator tolerance and rebound bronchoconstriction during regular inhaled β -agonist treatment by HANCOX, R.J., COWAN, J.O., FLANNERY, E.M., HERBISON, G.P., MCLACHLAN, C.R., TAYLOR, D.R.

“…There is uncertainty about the development of airway tolerance to β -agonists and the phenomenon of rebound bronchoconstriction on β -agonist withdrawal. We…”
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Randomised trial of an inhaled β2 agonist, inhaled corticosteroid and their combination in the treatment of asthma by Hancox, R J, Cowan, J O, Flannery, E M, Herbison, G P, McLachlan, C R, Wong, C S, Taylor, D R

“…BACKGROUND Although many asthmatic patients are treated with a combination of β2 agonist and corticosteroid inhalers, the clinical effects of combining the…”
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The Predictive Value of Exhaled Nitric Oxide Measurements in Assessing Changes in Asthma Control by JONES, STUART L, KITTELSON, JOHN, COWAN, JAN O, FLANNERY, ERIN M, HANCOX, ROBERT J, MCLACHLAN, CHRISTENE R, TAYLOR, D. ROBIN

“…Exhaled nitric oxide (eNO) levels are increased in untreated or unstable asthma and measurements can be made easily. Our aim was to assess the usefulness of…”
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Effects of terbutaline and budesonide on sputum cells and bronchial hyperresponsiveness in asthma by Aldridge, R E, Hancox, R J, Robin Taylor, D, Cowan, J O, Winn, M C, Frampton, C M, Town, G I

“…Previous studies have shown that the regular administration of short acting beta-agonists can be associated with adverse effects on airway caliber and…”
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The Influence of Polymorphism at Position 16 of the β2-Adrenoceptor on the Development of Tolerance to β-Agonist by Taylor, D. R., Hancox, R. J., McRae, W., Cowan, J. O., Flannery, E. M., McLachlan, C. R., Herbison, G. P.

“…Polymorphism at position 16 of the β2-adrenoceptor alters receptor down-regulation in vitro. Our aim was to compare the development of tolerance to (3-agonist…”
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D31 NONINVASIVE ASSESSMENT OF LUNG DISEASE: An Expression Signature Of 6 Genes Can Reliably Distinguish Eosinophilic And Neutrophilic Inflammation And Corticosteroid Response In Asthma by Baines, K J, Simpson, J L, Wood, L G, Scott, R J, Fibbens, N L, Powell, H, Cowan, D C, Taylor, D, Cowan, J O, Gibson, P G

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House dust mite allergen levels in university student accommodation in Dunedin by McRae, Wendy M

“…Quantifies the levels of Dermatophagoides pteronyssinus in different university student accommodation in Dunedin, and assesses relationships with housing…”
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Use of Exhaled Nitric Oxide Measurements to Guide Treatment in Chronic Asthma by Smith, Andrew D, Cowan, Jan O, Brassett, Karen P, Herbison, G. Peter, Taylor, D. Robin

“…The proper management of asthma with the use of inhaled corticosteroids requires the adjustment of doses in proportion to the patient's need for treatment. In…”
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Exhaled Nitric Oxide: A Predictor of Steroid Response by Smith, Andrew D, Cowan, Jan O, Brassett, Karen P, Filsell, Sue, McLachlan, Chris, Monti-Sheehan, Gabrielle, Herbison, G. Peter, Taylor, D. Robin

“…The initial management of patients who present with persistent respiratory symptoms includes recognizing those with the potential to benefit from inhaled…”
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A Longitudinal, Population-Based, Cohort Study of Childhood Asthma Followed to Adulthood by Sears, Malcolm R, Greene, Justina M, Willan, Andrew R, Wiecek, Elizabeth M, Taylor, D. Robin, Flannery, Erin M, Cowan, Jan O, Herbison, G. Peter, Silva, Phil A, Poulton, Richie

“…These investigators followed a large birth cohort with the use of questionnaires, lung-function tests, and allergy skin tests from the age of 3 to 26 years…”
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Diagnosing Asthma: Comparisons between Exhaled Nitric Oxide Measurements and Conventional Tests by Smith, Andrew D, Cowan, Jan O, Filsell, Sue, McLachlan, Chris, Monti-Sheehan, Gabrielle, Jackson, Pamela, Taylor, D. Robin

“…International guidelines recommend a range of clinical tests to confirm the diagnosis of asthma. These focus largely on identifying variable airflow…”
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