Search Results - "Cowan, Graeme J. M."

A novel malaria vaccine candidate antigen expressed in Tetrahymena thermophila by Cowan, Graeme J M, Bockau, Ulrike, Eleni-Muus, Janna, Aldag, Ingo, Samuel, Kay, Creasey, Alison M, Hartmann, Marcus W W, Cavanagh, David R

“…Development of effective malaria vaccines is hampered by the problem of producing correctly folded Plasmodium proteins for use as vaccine components. We have…”
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A malaria vaccine based on the polymorphic block 2 region of MSP-1 that elicits a broad serotype-spanning immune response by Cowan, Graeme J M, Creasey, Alison M, Dhanasarnsombut, Kelwalin, Thomas, Alan W, Remarque, Edmond J, Cavanagh, David R

“…Polymorphic parasite antigens are known targets of protective immunity to malaria, but this antigenic variation poses challenges to vaccine development. A…”
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Antibody responses to a novel Plasmodium falciparum merozoite surface protein vaccine correlate with protection against experimental malaria infection in Aotus monkeys by Cavanagh, David R, Kocken, Clemens H M, White, John H, Cowan, Graeme J M, Samuel, Kay, Dubbeld, Martin A, Voorberg-van der Wel, Annemarie, Thomas, Alan W, McBride, Jana S, Arnot, David E

“…The Block 2 region of the merozoite surface protein-1 (MSP-1) of Plasmodium falciparum has been identified as a target of protective immunity by a combination…”
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In Human Autoimmunity, a Substantial Component of the B Cell Repertoire Consists of Polyclonal, Barely Mutated IgG +ve B Cells by Cowan, Graeme J M, Miles, Katherine, Capitani, Lorenzo, Giguere, Sophie S B, Johnsson, Hanna, Goodyear, Carl, McInnes, Iain B, Breusch, Steffen, Gray, David, Gray, Mohini

“…B cells are critical for promoting autoimmunity and the success of B cell depletion therapy in rheumatoid arthritis (RA) confirms their importance in driving…”
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A Conserved TCRβ Signature Dominates a Highly Polyclonal T-Cell Expansion During the Acute Phase of a Murine Malaria Infection by Smith, Natasha L, Nahrendorf, Wiebke, Sutherland, Catherine, Mooney, Jason P, Thompson, Joanne, Spence, Philip J, Cowan, Graeme J M

“…CD4 αβ T-cells are key mediators of the immune response to a first infection, undergoing extensive activation and splenic expansion during the acute phase of…”
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Immunisation with anthrolysin O or a genetic toxoid protects against challenge with the toxin but not against Bacillus anthracis by Cowan, Graeme J.M, Atkins, Helen S, Johnson, Linda K, Titball, Richard W, Mitchell, Tim J

“…Abstract Anthrolysin O (ALO) is a toxin produced by Bacillus anthracis , the causative agent of anthrax. It is a member of the cholesterol-dependent cytolysin…”
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AIRRSHIP: simulating human B cell receptor repertoire sequences by Sutherland, Catherine, Cowan, Graeme J M

“…Abstract Summary Adaptive Immune Receptor Repertoire Sequencing is a rapidly developing field that has advanced understanding of the role of the adaptive…”
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Presence of Nonhemolytic Pneumolysin in Serotypes of Streptococcus pneumoniae Associated with Disease Outbreaks by Jefferies, Johanna M. C., Johnston, Calum H. G., Kirkham, Lea-Ann S., Cowan, Graeme J. M., Ross, Kirsty S., Smith, Andrew, Clarke, Stuart C., Brueggemann, Angela B., George, Robert C., Pichon, Bruno, Pluschke, Gerd, Pflüger, Valentin, Mitchell, Tim J.

“…Pneumolysin is an important virulence factor of the human pathogen Streptococcus pneumoniae. Sequence analysis of the ply gene from 121 clinical isolates of S…”
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Abnormal proliferation and spontaneous differentiation of myoblasts from a symptomatic female carrier of X-linked Emery–Dreifuss muscular dystrophy by Meinke, Peter, Schneiderat, Peter, Srsen, Vlastimil, Korfali, Nadia, Lê Thành, Phú, Cowan, Graeme J.M, Cavanagh, David R, Wehnert, Manfred, Schirmer, Eric C, Walter, Maggie C

“…Highlights • X-linked female presenting with EDMD1 not explained by uneven X-inactivation. • First EDMD blood phenotype with highly lobulated lymphocytes in…”
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Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator CD59 by Hughes, Timothy R., Ross, Kirsty S., Cowan, Graeme J.M., Sivasankar, Baalasubramanian, Harris, Claire L., Mitchell, Timothy J., Morgan, B. Paul

“…The unique species specificity of the bacterial cytolysin intermedilysin is explained by its requirement for the human complement regulator CD59 as the primary…”
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Presence of nonhemolytic pneumolysin in serotypes of Streptococcus pneumoniae assodated with disease outbreaks by JEFLERIES, Johanna M. C, JOHNSTON, Calum H. G, PLUSCHKE, Gerd, PFLÜGER, Valentin, MITCHELL, Tim J, KIRKHAM, Lea-Ann S, COWAN, Graeme J. M, ROSS, Kirsty S, SMITH, Andrew, CLARKE, Stuart C, BRUEGGEMANN, Angela B, GEORGE, Robert C, PICHON, Bruno

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Immunisation with anthrolysin O or a genetic toxoid protects against challenge with the toxin but not againstBacillus anthracis by Cowan, Graeme JM, Atkins, Helen S, Johnson, Linda K, Titball, Richard W, Mitchell, Tim J

“…Anthrolysin O (ALO) is a toxin produced byBacillus anthracis, the causative agent of anthrax. It is a member of the cholesterol-dependent cytolysin (CDC) group…”
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A Novel Malaria Vaccine Candidate Antigen Expressed in Tetrahymena thermophila: e87198 by Cowan, Graeme JM, Bockau, Ulrike, Eleni-Muus, Janna, Aldag, Ingo, Samuel, Kay, Creasey, Alison M, Hartmann, Marcus WW, Cavanagh, David R

“…Development of effective malaria vaccines is hampered by the problem of producing correctly folded Plasmodium proteins for use as vaccine components. We have…”
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Antibody Responses to a Novel Plasmodium falciparum Merozoite Surface Protein Vaccine Correlate with Protection against Experimental Malaria Infection in Aotus Monkeys: e83704 by Cavanagh, David R, Kocken, Clemens HM, White, John H, Cowan, Graeme JM, Samuel, Kay, Dubbeld, Martin A, Wel, Annemarie Voorberg-vander, Thomas, Alan W, McBride, Jana S, Arnot, David E

“…The Block 2 region of the merozoite surface protein-1 (MSP-1) of Plasmodium falciparum has been identified as a target of protective immunity by a combination…”
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Characterisation of the high affinity interaction between the human complement regulator CD59 and the Staphylococcus intermedius toxin, intermedilysin by Hughes, Timothy R., Cowan, Graeme J.M., Ross, Kirsty S., Mitchell, Timothy J., Morgan, B. Paul

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