Search Results - "Covre, Luciana Polaco"

Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5'-Monophosphate-Activated Protein Kinase by Müller-Durovic, Bojana, Lanna, Alessio, Covre, Luciana Polaco, Mills, Rachel S, Henson, Sian M, Akbar, Arne N

“…NK cells are the first line of defense against infected and transformed cells. Defective NK cell activity was shown to increase susceptibility for viral…”
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Senescence-related genes are associated with the immunopathology signature of American Tegumentary Leishmaniasis lesions and may predict progression to mucosal leishmaniasis by Fantecelle, Carlos Henrique, Polaco Covre, Luciana, Lopes, Paola Oliveira, Sarmento, Isabela Valim, Decote-Ricardo, Debora, Geraldo Freire de Lima, Celio, de Matos Guedes, Herbert Leonel, Pimentel, Maria Inês Fernandes, Conceição-Silva, Fatima, Maretti-Mira, Ana C, Borges, Valéria M, Pedreira de Carvalho, Lucas, de Carvalho, Edgar M, Mosser, David, Falqueto, Aloisio, Akbar, Arne N, Gomes, Daniel Claudio Oliveira

“…The American Tegumentary Leishmaniasis (ATL) is caused by protozoans of the genus Leishmania and varies from mild localized cutaneous leishmaniasis (LCL) form…”
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Lesional senescent CD4+ T cells mediate bystander cytolysis and contribute to the skin pathology of human cutaneous leishmaniasis by Covre, Luciana Polaco, Fantecelle, Carlos Henrique, Garcia de Moura, Renan, Oliveira Lopes, Paola, Sarmento, Isabela Valim, Freire-de-Lima, Celio Geraldo, Decote-Ricardo, Debora, de Matos Guedes, Herbert Leonel, da Fonsceca-Martins, Alessandra Marcia, de Carvalho, Lucas Pedreira, de Carvalho, Edgar Marcelino, Mosser, David M., Falqueto, Aloisio, Akbar, Arne N., Gomes, Daniel Claudio Oliveira

“…Cytotoxic activity is a hallmark of the immunopathogenesis in human cutaneous leishmaniasis (CL). In this study, we identified accumulation of CD4 + granzyme B…”
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PD-1 Blockade Modulates Functional Activities of Exhausted-Like T Cell in Patients With Cutaneous Leishmaniasis by Garcia de Moura, Renan, Covre, Luciana Polaco, Fantecelle, Carlos Henrique, Gajardo, Vitor Alejandro Torres, Cunha, Carla Baroni, Stringari, Lorenzzo Lyrio, Belew, Ashton Trey, Daniel, Camila Batista, Zeidler, Sandra Ventorin Von, Tadokoro, Carlos Eduardo, de Matos Guedes, Herbert Leonel, Zanotti, Raphael Lubiana, Mosser, David, Falqueto, Aloisio, Akbar, Arne N, Gomes, Daniel Claudio Oliveira

“…Patients infected by develop debilitating skin lesions. The role of inhibitory checkpoint receptors (ICRs) that induce T cell exhaustion during this disease is…”
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Increase of CD4+CD25highFoxP3+ cells impairs in vitro human microbicidal activity against Mycobacterium tuberculosis during latent and acute pulmonary tuberculosis by Stringari, Lorenzzo Lyrio, Covre, Luciana Polaco, da Silva, Flávia Dias Coelho, de Oliveira, Vivian Leite, Campana, Maria Carolina, Hadad, David Jamil, Palaci, Moisés, Salgame, Padmini, Dietze, Reynaldo, Gomes, Daniel Cláudio de Oliveira, Ribeiro-Rodrigues, Rodrigo

“…Background Regulatory T cells (Tregs) play a critical role during Mycobacterium tuberculosis ( Mtb ) infection, modulating host responses while neutralizing…”
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Intranasal immunization with chitosan microparticles enhances LACK-DNA vaccine protection and induces specific long-lasting immunity against visceral leishmaniasis by Gomes, Daniel Claudio Oliveira, Souza, Beatriz Lilian da Silva Costa, Schwedersky, Rodrigo Porto, Covre, Luciana Polaco, de Matos Guedes, Herbert Leonel, Lopes, Ulisses Gazos, Ré, Maria Inês, Rossi-Bergmann, Bartira

“…Development of a protective vaccine against Leishmania depends on antigen formulation and adjuvants that induce specific immunity and long-lasting immune…”
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NKG2C+CD57+ natural killer cells with senescent features are induced during cutaneous leishmaniasis and accumulate in patients with lesional healing impairment by Covre, Luciana Polaco, Fantecelle, Carlos Henrique, Queiroz, Ariadne Mendes, Fardin, Julia Miranda, Miranda, Pedro Henrique, Henson, Sian, Fonseca-Martins, Alessandra Marcia da, de Matos Guedes, Herbert Leonel, Mosser, David, Falqueto, Aloisio, Akbar, Arne, Gomes, Daniel Claudio Oliveira

“…Natural killer (NK) cells include different subsets with diverse effector capacities that are poorly understood in the context of parasitic diseases. Here, we…”
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Transcriptomic landscape of skin lesions in cutaneous leishmaniasis reveals a strong CD8+ T cell immunosenescence signature linked to immunopathology by Fantecelle, Carlos Henrique, Covre, Luciana Polaco, Garcia de Moura, Renan, Guedes, Herbert Leonel de Matos, Amorim, Camila Farias, Scott, Phillip, Mosser, David, Falqueto, Aloisio, Akbar, Arne N., Gomes, Daniel Claudio Oliveira

“…The severity of lesions that develop in patients infected by Leishmania braziliensis is mainly associated with a highly cytotoxic and inflammatory cutaneous…”
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Intranasal delivery of LaAg vaccine improves immunity of aged mice against visceral Leishmaniasis by Salgado, Caio Loureiro, Corea, Andrés Felipe Mendéz, Covre, Luciana Polaco, Fonseca-Martins, Alessandra Marcia da, Falqueto, Aloisio, Guedes, Herbert Leonel de Matos, Rossi-Bergmann, Bartira, Gomes, Daniel Cláudio Oliviera

“…•The age of mice directly affects leishmania parasitemia.•Use of the LaAg vaccine intranasally helps in the process of controlling parasite in young and…”
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Ageing impairs protective immunity and promotes susceptibility to murine visceral leishmaniasis by Loureiro Salgado, Caio, Mendéz Corea, Andrés Felipe, Covre, Luciana Polaco, De Matos Guedes, Herbet Leonel, Falqueto, Aloisio, Gomes, Daniel Cláudio Oliviera

“…It is well accepted that the impact of diseases is generally more detrimental in elderly individuals than in younger ones. Changes in the immune system due to…”
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Pam3CSK4 adjuvant given intranasally boosts anti-Leishmania immunogenicity but not protective immune responses conferred by LaAg vaccine against visceral leishmaniasis by Salgado, Caio Loureiro, Dias, Emmanoel Loss, Stringari, Lorenzzo Lyrio, Covre, Luciana Polaco, Dietze, Reynaldo, Lima Pereira, Fausto Edmundo, de Matos Guedes, Herbet Leonel, Rossi-Bergmann, Bartira, Gomes, Daniel Claudio Oliveira

“…The use of adjuvants in vaccine formulations is a well-established practice to improve immunogenicity and protective immunity against diseases. Previously, we…”
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Compartmentalized cytotoxic immune response leads to distinct pathogenic roles of natural killer and senescent CD8+ T cells in human cutaneous leishmaniasis by Covre, Luciana Polaco, Devine, Oliver Patrick, Garcia de Moura, Renan, Vukmanovic‐Stejic, Milica, Dietze, Reynaldo, Ribeiro‐Rodrigues, Rodrigo, Guedes, Herbert Leonel de Matos, Lubiana Zanotti, Raphael, Falqueto, Aloisio, Akbar, Arne N., Gomes, Daniel Claudio Oliveira

“…Summary Cytotoxic activity mediated by CD8+ T cells is the main signature of the immunopathogenesis of cutaneous leishmaniasis (CL). Here, we performed a broad…”
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Increase of CD4.sup.+CD25.sup.highFoxP3.sup.+ cells impairs in vitro human microbicidal activity against Mycobacterium tuberculosis during latent and acute pulmonary tuberculosis by Stringari, Lorenzzo Lyrio, Covre, Luciana Polaco, da Silva, Flávia Dias Coelho, de Oliveira, Vivian Leite, Campana, Maria Carolina, Hadad, David Jamil, Palaci, Moisés, Salgame, Padmini, Dietze, Reynaldo, Gomes, Daniel Cláudio de Oliveira, Ribeiro-Rodrigues, Rodrigo

“…Background Regulatory T cells (Tregs) play a critical role during Mycobacterium tuberculosis (Mtb) infection, modulating host responses while neutralizing…”
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Killer Cell Lectin-like Receptor G1 (KLRG1) inhibits NK cell function through activation of AMP-activated Protein Kinase by Müller-Durovic, Bojana, Lanna, Alessio, Covre, Luciana Polaco, Mills, Rachel S., Henson, Sian M., Akbar, Arne N.

“…NK cells are the first line of defense against infected and transformed cells. Defective NK cell activity has been shown to increase susceptibility for viral…”
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Intranasal vaccination with adjuvant-free S. aureus antigens effectively protects mice against experimental sepsis by Stegmiller, Nataly Pescinalli, Barcelos, Estevão Carlos, Leal, Janine Miranda, Covre, Luciana Polaco, Donatele, Dirlei Molinari, de Matos Guedes, Herbet Leonel, Cunegundes, Marco Cesar, Rodrigues, Rodrigo Ribeiro, Gomes, Daniel Cláudio Oliviera

“…Abstract Staphylococcus aureus ( S. aureus ) is a Gram-positive coccal bacterium comprising part of the human skin, nares and gastrointestinal tract normal…”
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Diet-induced obesity promotes systemic inflammation and increased susceptibility to murine visceral leishmaniasis by Sarnáglia, Glênia Daros, Covre, Luciana Polaco, Pereira, Fausto Edmundo Lima, DE Matos Guedes, Herbert Leonel, Faria, Ana Maria Caetano, Dietze, Reynaldo, Rodrigues, Rodrigo Ribeiro, Maioli, Tatiani Uceli, Gomes, Daniel Cláudio Oliviera

“…Obesity is the main causal factor for metabolic syndrome and chronic systemic inflammation, which impacts on immune function and increases susceptibility to…”
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Peripheral blood CD4.sup.+/CD25.sup.+ regulatory T cells in alcoholic patients with Strongyloides stercoralis infection by Ribeiro, Steveen Rios, Covre, Luciana Polaco, Stringari, Lorenzzo Lyrio, da Penha Zago-Gomes, Maria, Gomes, Daniel Cláudio Oliveira, Pereira, Fausto Edmundo Lima

“…An increased number of regulatory T (Treg) cells has been reported in patients with HTLV-1 and Strongyloides stercoralis co-infection, suggesting the…”
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Intranasal vaccination with killed Leishmania amazonensis promastigotes antigen (LaAg) associated with CAF01 adjuvant induces partial protection in BALB/c mice challenged with Leishmania (infantum) chagasi by Leal, Janine Miranda, Mosquini, Marcelle, Covre, Luciana Polaco, Stagmiller, Nataly Pescinalli, Rodrigues, Rodrigo Ribeiro, Christensen, Dennis, de Matos Guedes, Herbert Leonel, Guedes, Herbert Leonel De Matos, Rossi-Bergmann, Bartira, Gomes, Daniel Cláudio De Oliviera

“…The CAF01 adjuvant has previously been shown to be safe for human use and to be a potent adjuvant for several vaccine antigens. In the present work, we sought…”
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Peripheral blood CD4+/CD25+ regulatory T cells in alcoholic patients with Strongyloides stercoralis infection by Ribeiro, Steveen Rios, Covre, Luciana Polaco, Stringari, Lorenzzo Lyrio, da Penha Zago-Gomes, Maria, Gomes, Daniel Cláudio Oliveira, Pereira, Fausto Edmundo Lima

“…An increased number of regulatory T (Treg) cells has been reported in patients with HTLV-1 and Strongyloides stercoralis co-infection, suggesting the…”
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