Search Results - "Covolan, Luciene"

Is Mossy Fiber Sprouting a Potential Therapeutic Target for Epilepsy? by Cavarsan, Clarissa F, Malheiros, Jackeline, Hamani, Clement, Najm, Imad, Covolan, Luciene

“…Mesial temporal lobe epilepsy (MTLE) caused by hippocampal sclerosis is one of the most frequent focal epilepsies in adults. It is characterized by focal…”
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Deep Brain Stimulation Reverses Anhedonic-Like Behavior in a Chronic Model of Depression: Role of Serotonin and Brain Derived Neurotrophic Factor by Hamani, Clement, Machado, Danilo C, Hipólide, Débora C, Dubiela, Francisco P, Suchecki, Deborah, Macedo, Carlos E, Tescarollo, Fabio, Martins, Uilton, Covolan, Luciene, Nobrega, José N

“…Background Deep brain stimulation (DBS) is being investigated as a treatment for major depression, but its mechanisms of action are still unknown. We have…”
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Deep brain stimulation of the anterior thalamus attenuates PTZ kindling with concomitant reduction of adenosine kinase expression in rats by Gimenes, Christiane, Motta Pollo, Maria Luiza, Diaz, Eduardo, Hargreaves, Eric L., Boison, Detlev, Covolan, Luciene

“…Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is an emerging therapy to provide seizure control in patients with refractory…”
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Deep brain stimulation in rats: Different targets induce similar antidepressant-like effects but influence different circuits by Hamani, Clement, Amorim, Beatriz O, Wheeler, Anne L, Diwan, Mustansir, Driesslein, Klaus, Covolan, Luciene, Butson, Christopher R, Nobrega, José N

“…Abstract Recent studies in patients with treatment-resistant depression have shown similar results with the use of deep brain stimulation (DBS) in the…”
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Deep brain stimulation mitigates memory deficits in a rodent model of traumatic brain injury by Rabelo, Thallita K., Campos, Ana Carolina P., Almeida Souza, Thiago H., Mahmud, Faiza, Popovic, Milos R., Covolan, Luciene, Betta, Victor H.C., DaCosta, Leodante, Lipsman, Nir, Diwan, Mustansir, Hamani, Clement

“…Traumatic brain injury (TBI) is a major life-threatening event. In addition to neurological deficits, it can lead to long-term impairments in attention and…”
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Effects of anterior thalamic nucleus deep brain stimulation in chronic epileptic rats by Covolan, Luciene, de Almeida, Antônio-Carlos G, Amorim, Beatriz, Cavarsan, Clarissa, Miranda, Maisa Ferreira, Aarão, Mayra C, Madureira, Ana Paula, Rodrigues, Antônio M, Nobrega, José N, Mello, Luiz E, Hamani, Clement

“…Deep brain stimulation (DBS) has been investigated for the treatment of epilepsy. In rodents, an increase in the latency for the development of seizures and…”
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Manganese-enhanced magnetic resonance imaging detects mossy fiber sprouting in the pilocarpine model of epilepsy by Malheiros, Jackeline M., Polli, Roberson S., Paiva, Fernando F., Longo, Beatriz M., Mello, Luiz E., Silva, Afonso C., Tannús, Alberto, Covolan, Luciene

“…Summary Purpose:  Mossy fiber sprouting (MFS) is a frequent finding following status epilepticus (SE). The present study aimed to test the feasibility of using…”
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Glutamate reduces glucose utilization while concomitantly enhancing AQP9 and MCT2 expression in cultured rat hippocampal neurons by Tescarollo, Fabio, Covolan, Luciene, Pellerin, Luc

“…The excitatory neurotransmitter glutamate has been reported to have a major impact on brain energy metabolism. Using primary cultures of rat hippocampal…”
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Reduced hippocampal manganese-enhanced MRI (MEMRI) signal during pilocarpine-induced status epilepticus: Edema or apoptosis? by Malheiros, Jackeline Moraes, Persike, Daniele Suzete, Castro, Leticia Urbano Cardoso de, Sanches, Talita Rojas Cunha, Andrade, Lúcia da Conceição, Tannús, Alberto, Covolan, Luciene

“…Highlights • We investigated the MEMRI signal after short periods of SE. • We examined changes in hippocampal caspase-3 activation, T2 relaxometry, aquaporin…”
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Facial nerve identification with fluorescent dye in rats by de Melo, Giulianno Molina, Cervantes, Onivaldo, Covolan, Luciene, Baptista, Heloisa Allegro, Ferreira, Elenn Soares, Abrahao, Marcio

“…PURPOSE The parotidectomy technique still has an elevated paresis and paralysis index, lowering patient life's quality. The correct identification of the…”
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An Experimental Model of Neonatal Nociceptive Stimulation in Rats by Jackeline Malheiros, Cristiane Amaral, Ana Leslie, Ruth Guinsburg, Luciene Covolan

“…In order to survive, preterm and/or sick neonates need diagnostic and therapeutic measures that may cause discomfort, stress and pain during a critical period…”
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Manganese-enhanced magnetic resonance imaging in the acute phase of the pilocarpine-induced model of epilepsy by Malheiros, Jackeline Moraes, Longo, Beatriz Monteiro, Tannús, Alberto, Covolan, Luciene

“…Magnetic resonance images are useful in the study of experimental models of temporal lobe epilepsy. The manganese-enhanced MRI (MEMRI) technique is of interest…”
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Sprouting of mossy fibers and the vacating of postsynaptic targets in the inner molecular layer of the dentate gyrus by Longo, Beatriz, Covolan, Luciene, Chadi, Gerson, Mello, Luiz Eugênio A.M

“…Aberrant mossy fiber sprouting, which presumably results from hilar mossy cell death after status epilepticus (SE), is a frequently studied feature of temporal…”
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Neonatal nociceptive stimulation results in pain sensitization, reduction of hippocampal 5-HT1A receptor, and p-CREB expression in adult female rats by Malheiros, Jackeline, Amaral, Cristiane, da Silva, Luiz Severino, Guinsburg, Ruth, Covolan, Luciene

“…Painful invasive procedures are often performed on newborns admitted to intensive care units (ICU). The acute and long-term effects caused by these stimuli can…”
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Male rats are more vulnerable to pentylenetetrazole-kindling model but females have more spatial memory-related deficits by Pollo, Maria Luiza Motta, Gimenes, Christiane, Covolan, Luciene

“…•PTZ kindling has sex-specific vulnerability.•Seizure vulnerability to PTZ is higher in males than females.•PTZ kindling causes more pronounced memory deficits…”
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Effects and mechanisms of anterior thalamus nucleus deep brain stimulation for epilepsy: A scoping review of preclinical studies by Covolan, Luciene, Motta Pollo, Maria Luiza, dos Santos, Pedro Bastos, Betta, Victor Hugo Cardoso, Saad Barbosa, Felipe Farinha, Covolan, Luciano Arnaldo Mian, Gimenes, Christiane, Hamani, Clement

“…Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is a safe and effective intervention for the treatment of certain forms of epilepsy…”
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The neural response to deep brain stimulation of the anterior nucleus of the thalamus: A MEMRI and c-Fos study by Gimenes, Christiane, Malheiros, Jackeline Moraes, Battapady, Harsha, Tannus, Alberto, Hamani, Clement, Covolan, Luciene

“…•In rat, we tested how 1 h of ANT DBS affects the cell activity in the circuit of Papez.•Reduction of cell excitability is demonstrated after high frequency…”
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Chronic unpredictable restraint stress increases hippocampal pro-inflammatory cytokines and decreases motivated behavior in rats by Mograbi, Karla De Michelis, Suchecki, Deborah, da Silva, Sérgio Gomes, Covolan, Luciene, Hamani, Clement

“…Most chronic stress protocols are too laborious or do not abide by the two main characteristics of the stress concept: uncontrollability and unpredictability…”
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Anatomical study of a temporal bone from a non-human primate (Callithrix sp) by Borin, Andrei, Covolan, Luciene, Mello, Luiz Eugênio, Okada, Daniel Mochida, Cruz, Oswaldo Laércio Mendonça, Testa, Jose Ricardo Gurgel

“…The search for experimental (animal) models is essential to the development of clinical studies. To demonstrate, by means of micro dissection techniques, the…”
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Cortical Modulation of Pain: Comments on “Exacerbation of tonic but not phasic pain by entorhinal cortex lesions” by Malheiros, Jackeline Moraes, Guinsburg, Ruth, Covolan, Luciene

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