Search Results - "Covington, Paul S."

Evaluation of the Irritable Bowel Syndrome Quality of Life (IBS-QOL) questionnaire in diarrheal-predominant irritable bowel syndrome patients by Andrae, David A, Patrick, Donald L, Drossman, Douglas A, Covington, Paul S

“…Diarrhea-predominant irritable bowel syndrome (IBS-d) significantly diminishes the health-related quality of life (HRQOL) of patients. Psychological and social…”
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Sphincter of Oddi Function and Risk Factors for Dysfunction by Afghani, Elham, Lo, Simon K, Covington, Paul S, Cash, Brooks D, Pandol, Stephen J

“…The sphincter of Oddi (SO) is a smooth muscle valve regulating the flow of biliary and pancreatic secretions into the duodenum, initially described in 1887 by…”
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Impact of patient and disease characteristics on the efficacy and safety of eluxadoline for IBS-D: a subgroup analysis of phase III trials by Lacy, Brian E., Harris, Lucinda A., Chang, Lin, Lucak, Susan, Gutman, Catherine, Dove, Leonard S., Covington, Paul S., Lembo, Anthony

“…Background: Irritable bowel syndrome with diarrhea (IBS-D) is a prevalent gastrointestinal (GI) disorder with a varied presentation, often overlapping with…”
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Item-Level Assessment of the Irritable Bowel Syndrome Quality of Life Questionnaire in Patients With Diarrheal Irritable Bowel Syndrome by Andrae, David A., PhD, Covington, Paul S., MD, Patrick, Donald L., PhD, MSPH

“…Abstract Background In previous studies, the Irritable Bowel Syndrome Quality of Life (IBS-QOL) instrument has been determined to have good measurement…”
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Eluxadoline for Irritable Bowel Syndrome with Diarrhea by Lembo, Anthony J, Lacy, Brian E, Zuckerman, Marc J, Schey, Ron, Dove, Leonard S, Andrae, David A, Davenport, J. Michael, McIntyre, Gail, Lopez, Rocio, Turner, Lisa, Covington, Paul S

“…In two randomized trials, eluxadoline was more effective than placebo in reducing abdominal pain and improving stool consistency in patients who had irritable…”
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Safety of Eluxadoline in Patients with Irritable Bowel Syndrome with Diarrhea by Cash, Brooks D, Lacy, Brian E, Schoenfeld, Philip S, Dove, Leonard S, Covington, Paul S

“…Eluxadoline is a mixed μ-opioid receptor (OR) and κ-OR agonist and δ-OR antagonist, approved for the treatment of irritable bowel syndrome with diarrhea…”
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Eluxadoline Benefits Patients With Irritable Bowel Syndrome With Diarrhea in a Phase 2 Study by Dove, Leonard S, Lembo, Anthony, Randall, Charles W, Fogel, Ronald, Andrae, David, Davenport, J. Michael, Mcintyre, Gail, Almenoff, June S, Covington, Paul S

“…Background & Aims Simultaneous agonism of the μ-opioid receptor and antagonism of the δ-opioid receptor can reduce abdominal pain and diarrhea in patients with…”
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Eluxadoline Efficacy in IBS-D Patients Who Report Prior Loperamide Use by Lacy, Brian E, Chey, William D, Cash, Brooks D, Lembo, Anthony J, Dove, Leonard S, Covington, Paul S

“…Irritable bowel syndrome with diarrhea (IBS-D) is often managed with over-the-counter therapies such as loperamide, though with limited success. This analysis…”
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Effects of treatment with eluxadoline on abdominal pain in patients with IBS‐D: Additional post hoc analyses of Phase 3 trials by Lembo, Anthony J., Covington, Paul S., Dove, Leonard S., Andrae, David A.

“…Background Recurring abdominal pain is a characteristic and often unpredictable and debilitating symptom of irritable bowel syndrome with diarrhea (IBS‐D)…”
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Su1384 A Retrospective Assessment of Area Under the Pain Curve in Quantifying Daily Pain Assessments in Irritable Bowel Syndrome With Diarrhea by Covington, Paul S, Dove, Scott, Andrae, David

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Effect of Hepatic Impairment on Eluxadoline Pharmacokinetics by Marbury, Thomas C., Berg, Jolene Kay, Dove, Leonard S., Covington, Paul S.

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Eluxadoline Demonstrates a Lack of Abuse Potential in Phase 2 and 3 Studies of Patients With Irritable Bowel Syndrome With Diarrhea by Fant, Reginald V, Henningfield, Jack E, Cash, Brooks D, Dove, Leonard S, Covington, Paul S

“…Background & Aims Eluxadoline is approved by the Food and Drug Administration for the treatment of adults with irritable bowel syndrome with diarrhea (IBS-D)…”
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Response to Lai by Cash, Brooks D, Lacy, Brian E, Schoenfeld, Philip S, Dove, Leonard S, Covington, Paul S

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Su1385 Effect of Eluxadoline on Health-Related Quality of Life in Adults With Irritable Bowel Syndrome With Diarrhea: Results From Two Randomized, Double-Blind, Placebo-Controlled Phase 3 Trials by Andrae, David, Buono, Jessica L, Covington, Paul S

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Safety of Eluxadoline in Patients With IBS-D Without a Gallbladder by Cash, Brooks D, Lacy, Brian E, Schoenfeld, Philip S, Dove, Leonard S, Covington, Paul S

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Su1204 A 1-Month Trial With Eluxadoline for IBS-D Predicts a Durable Response: Continuation Analysis of Response in Two Phase 3 Studies by Chey, William D, Andrae, David, Dove, Leonard S, Covington, Paul S

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Response to Croteau and Barkin by Cash, Brooks D, Lacy, Brian E, Schoenfeld, Philip S, Dove, Leonard S, Covington, Paul S

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Su1383 Effects of Eluxadoline on Abdominal Pain in Patients With Irritable Bowel Syndrome With Diarrhea: Results of 2 Phase 3 Clinical Trials by Lembo, Anthony, Dove, Scott, Andrae, David, Turner, Lisa, Davenport, J. Michael, Covington, Paul S

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Su1380 Consistency in Efficacy Outcomes of Eluxadoline-Treated Patients With Irritable Bowel Syndrome With Diarrhea Using Recent and Traditional Endpoints by Zuckerman, Marc, Dove, Scott, Andrae, David, Davenport, J. Michael, Turner, Lisa, Lopez, Rocio, Covington, Paul S

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1131 A Case Review of Pancreatitis and Hepatobiliary Events in the Phase 2 and Phase 3 Clinical Trials of Eluxadoline by Cash, Brooks D, Lacy, Brian, Schoenfeld, Philip, Dove, Leonard S, Covington, Paul S

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