Search Results - "Covington, E"

A standardized protocol for repeated social defeat stress in mice by Golden, Sam A, Covington, Herbert E, Berton, Olivier, Russo, Scott J

“…A major impediment to novel drug development has been the paucity of animal models that accurately reflect symptoms of affective disorders. In animal models,…”
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Fighting Females: Neural and Behavioral Consequences of Social Defeat Stress in Female Mice by Newman, Emily L., Covington, Herbert E., Suh, Junghyup, Bicakci, Matthew B., Ressler, Kerry J., DeBold, Joseph F., Miczek, Klaus A.

“…Despite the twofold higher prevalence of major depressive and posttraumatic stress disorders in women compared with men, most clinical and preclinical studies…”
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Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity by Maze, Ian, Covington, Herbert E. III, Dietz, David M, LaPlant, Quincey, Renthal, William, Russo, Scott J, Mechanic, Max, Mouzon, Ezekiell, Neve, Rachael L, Haggarty, Stephen J, Ren, Yanhua, Sampath, Srihari C, Hurd, Yasmin L, Greengard, Paul, Tarakhovsky, Alexander, Schaefer, Anne, Nestler, Eric J

“…Cocaine-induced alterations in gene expression cause changes in neuronal morphology and behavior that may underlie cocaine addiction. In mice, we identified an…”
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Cell Type-Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward by Lobo, Mary Kay, Covington, Herbert E. III, Chaudhury, Dipesh, Friedman, Allyson K, Sun, HaoSheng, Damez-Werno, Diane, Dietz, David M, Zaman, Samir, Koo, Ja Wook, Kennedy, Pamela J, Mouzon, Ezekiell, Mogri, Murtaza, Neve, Rachael L, Deisseroth, Karl, Han, Ming-Hu, Nestler, Eric J

“…The nucleus accumbens is a key mediator of cocaine reward, but the distinct roles of the two subpopulations of nucleus accumbens projection neurons, those…”
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A Role for Repressive Histone Methylation in Cocaine-Induced Vulnerability to Stress by Covington, Herbert E., Maze, Ian, Sun, HaoSheng, Bomze, Howard M., DeMaio, Kristine D., Wu, Emma Y., Dietz, David M., Lobo, Mary Kay, Ghose, Subroto, Mouzon, Ezekiel, Neve, Rachael L., Tamminga, Carol A., Nestler, Eric J.

“…Substance abuse increases an individual's vulnerability to stress-related illnesses, which is presumably mediated by drug-induced neural adaptations that alter…”
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Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex by Covington, 3rd, Herbert E, Lobo, Mary Kay, Maze, Ian, Vialou, Vincent, Hyman, James M, Zaman, Samir, LaPlant, Quincey, Mouzon, Ezekiel, Ghose, Subroto, Tamminga, Carol A, Neve, Rachael L, Deisseroth, Karl, Nestler, Eric J

“…Brain stimulation and imaging studies in humans have highlighted a key role for the prefrontal cortex in clinical depression; however, it remains unknown…”
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Antidepressant Actions of Histone Deacetylase Inhibitors by Covington, Herbert E., III, Maze, Ian, LaPlant, Quincey C, Vialou, Vincent F, Ohnishi, Yoshinori N, Berton, Olivier, Fass, Dan M, Renthal, William, Rush, Augustus J., III, Wu, Emma Y, Ghose, Subroto, Krishnan, Vaishnav, Russo, Scott J, Tamminga, Carol, Haggarty, Stephen J, Nestler, Eric J

“…Persistent symptoms of depression suggest the involvement of stable molecular adaptations in brain, which may be reflected at the level of chromatin…”
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Escalated or suppressed cocaine reward, tegmental BDNF, and accumbal dopamine caused by episodic versus continuous social stress in rats by Miczek, Klaus A, Nikulina, Ella M, Shimamoto, Akiko, Covington, 3rd, Herbert E

“…The neural link between ostensibly aversive stress experiences and intensely rewarding drug taking remains to be delineated. Epidemiological data associate…”
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Mesolimbic dopamine neurons in the brain reward circuit mediate susceptibility to social defeat and antidepressant action by Cao, Jun-Li, Covington, 3rd, Herbert E, Friedman, Allyson K, Wilkinson, Matthew B, Walsh, Jessica J, Cooper, Donald C, Nestler, Eric J, Han, Ming-Hu

“…We previously reported that the activity of mesolimbic dopamine neurons of the ventral tegmental area (VTA) is a key determinant of behavioral susceptibility…”
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Antidepressant action of HDAC inhibition in the prefrontal cortex by Covington, H.E, Maze, I, Vialou, V, Nestler, E.J

“…Highlights • We studied histone acetylation in the medial prefrontal cortex in stress models. • Chronic social stress increased histone acetylation levels in…”
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Persistent increase of I.V. cocaine self-administration in a subgroup of C57BL/6J male mice after social defeat stress by Arena, Danielle T., Covington, Herbert E., DeBold, Joseph F., Miczek, Klaus A.

“…Rationale Stressful life experiences can persistently increase the motivation for, and consumption of, intensely rewarding stimuli, like cocaine, over time. In…”
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MeCP2-Mediated Transcription Repression in the Basolateral Amygdala May Underlie Heightened Anxiety in a Mouse Model of Rett Syndrome by Adachi, Megumi, Autry, Anita E, Covington, Herb E., III, Monteggia, Lisa M

“…Rett syndrome (RTT) is an X-linked neurodevelopmental disorder that results from loss of function mutations in the methyl-CpG binding protein 2 (MECP2) gene…”
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Histone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli by Renthal, William, Maze, Ian, Krishnan, Vaishnav, Covington, Herbert E., Xiao, Guanghua, Kumar, Arvind, Russo, Scott J., Graham, Ami, Tsankova, Nadia, Kippin, Tod E., Kerstetter, Kerry A., Neve, Rachael L., Haggarty, Stephen J., McKinsey, Timothy A., Bassel-Duby, Rhonda, Olson, Eric N., Nestler, Eric J.

“…Previous work has identified alterations in histone acetylation in animal models of drug addiction and depression. However, the mechanisms which integrate…”
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Genome-wide Analysis of Chromatin Regulation by Cocaine Reveals a Role for Sirtuins by Renthal, William, Kumar, Arvind, Xiao, Guanghua, Wilkinson, Matthew, Covington, Herbert E., Maze, Ian, Sikder, Devanjan, Robison, Alfred J., LaPlant, Quincey, Dietz, David M., Russo, Scott J., Vialou, Vincent, Chakravarty, Sumana, Kodadek, Thomas J., Stack, Ashley, Kabbaj, Mohamed, Nestler, Eric J.

“…Changes in gene expression contribute to the long-lasting regulation of the brain's reward circuitry seen in drug addiction; however, the specific genes…”
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Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens by Nestler, Eric J, LaPlant, Quincey, Vialou, Vincent, Covington, Herbert E, Dumitriu, Dani, Feng, Jian, Warren, Brandon L, Maze, Ian, Dietz, David M, Watts, Emily L, Iñiguez, Sergio D, Koo, Ja Wook, Mouzon, Ezekiell, Renthal, William, Hollis, Fiona, Wang, Hui, Noonan, Michele A, Ren, Yanhua, Eisch, Amelia J, Bolaños, Carlos A, Kabbaj, Mohamed, Xiao, Guanghua, Neve, Rachael L, Hurd, Yasmin L, Oosting, Ronald S, Fan, Gouping, Morrison, John H

“…The authors find that the expression of the DNA methyltransferase Dnmt3a in mice is regulated by chronic cocaine and chronic social defeat stress in the…”
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ΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses by LaPlant, Quincey C, Watts, Emily L, Dietz, David M, Vialou, Vincent, Ohnishi, Yoko H, Wallace, Deanna L, Steiner, Michel A, Tamminga, Carol A, Ohnishi, Yoshinori N, Mouzon, Ezekiell, Warren, Brandon L, Bolaños, Carlos A, Nestler, Eric J, Neve, Rachael L, Rush, Augustus J, Iñiguez, Sergio D, Ghose, Subroto, Krishnan, Vaishnav, Robison, Alfred J, Covington, Herbert E, Berton, Olivier

“…This study reports that the induction of the transcription factor ΔFosB is critical for mice to show resilience to the effects of chronic social defeat stress…”
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Excessive alcohol consumption after exposure to two types of chronic social stress: intermittent episodes vs. continuous exposure in C57BL/6J mice with a history of drinking by Miczek, Klaus A., Akdilek, Naz, Ferreira, Vania M. M., Kenneally, Elizabeth, Leonard, Michael Z., Covington, Herbert E.

“…Rationale The attraction to alcohol can be greatly increased when it is consumed in a social context. While pro-social interactions can potentiate voluntary…”
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Increasing the validity of experimental models for depression by Dzirasa, Kafui, Covington III, Herbert E.

“…Major depressive disorder (MDD) is a central nervous system disorder characterized by the culmination of profound disturbances in mood and affective…”
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To fight or not to fight: activation of the mPFC during decision to engage in aggressive behavior after ethanol consumption in a novel murine model by Miczek, Klaus A., Akdilek, Naz, Ferreira, Vania M. M., Leonard, Michael Z., Marinelli, Lillian R., Covington, Herbert E.

“…Rationale Alcohol consumption is a common antecedent of aggressive behavior. The effects of alcohol on the decision to engage in aggression in preference over…”
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Histone serotonylation in dorsal raphe nucleus contributes to stress- and antidepressant-mediated gene expression and behavior by Al-Kachak, Amni, Di Salvo, Giuseppina, Fulton, Sasha L., Chan, Jennifer C, Farrelly, Lorna A., Lepack, Ashley E., Bastle, Ryan M., Kong, Lingchun, Cathomas, Flurin, Newman, Emily L., Menard, Caroline, Ramakrishnan, Aarthi, Safovich, Polina, Lyu, Yang, Covington, Herbert E., Shen, Li, Gleason, Kelly, Tamminga, Carol A., Russo, Scott J., Maze, Ian

“…Mood disorders are an enigmatic class of debilitating illnesses that affect millions of individuals worldwide. While chronic stress clearly increases incidence…”
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