Search Results - "Covey, Douglas F."

The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response by Blanc, Mathieu, Hsieh, Wei Yuan, Robertson, Kevin A., Kropp, Kai A., Forster, Thorsten, Shui, Guanghou, Lacaze, Paul, Watterson, Steven, Griffiths, Samantha J., Spann, Nathanael J., Meljon, Anna, Talbot, Simon, Krishnan, Kathiresan, Covey, Douglas F., Wenk, Markus R., Craigon, Marie, Ruzsics, Zsolts, Haas, Jürgen, Angulo, Ana, Griffiths, William J., Glass, Christopher K., Wang, Yuqin, Ghazal, Peter

“…Recent studies suggest that the sterol metabolic network participates in the interferon (IFN) antiviral response. However, the molecular mechanisms linking IFN…”
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Fatty acid synthesis configures the plasma membrane for inflammation in diabetes by Wei, Xiaochao, Song, Haowei, Yin, Li, Rizzo, Michael G., Sidhu, Rohini, Covey, Douglas F., Ory, Daniel S., Semenkovich, Clay F.

“…Mice with macrophages deficient in fatty acid synthase exhibit lower levels of diabetes-related insulin resistance and inflammation, qualities that are…”
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Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex by Castellano, Brian M., Thelen, Ashley M., Moldavski, Ofer, Feltes, McKenna, van der Welle, Reini E. N., Mydock-McGrane, Laurel, Jiang, Xuntian, van Eijkeren, Robert J, Davis, Oliver B., Louie, Sharon M., Perera, Rushika M., Covey, Douglas F., Nomura, Daniel K., Ory, Daniel S., Zoncu, Roberto

“…The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that becomes activated at the lysosome in response to…”
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Structural basis of Smoothened regulation by its extracellular domains by Byrne, Eamon F. X., Sircar, Ria, Miller, Paul S., Hedger, George, Luchetti, Giovanni, Nachtergaele, Sigrid, Tully, Mark D., Mydock-McGrane, Laurel, Covey, Douglas F., Rambo, Robert P., Sansom, Mark S. P., Newstead, Simon, Rohatgi, Rajat, Siebold, Christian

“…Structural studies show that the activity of the G-protein-coupled receptor Smoothened is modulated by ligand-regulated interactions between its extracellular…”
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5β-Dihydrosteroids: Formation and Properties by Penning, Trevor M, Covey, Douglas F

“…5β-Dihydrosteroids are produced by the reduction of Δ -3-ketosteroids catalyzed by steroid 5β-reductase (AKR1D1). By analogy with steroid 5α-reductase, genetic…”
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Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis by Wang, Xiaobo, Cai, Bishuang, Yang, Xiaoming, Sonubi, Oluwatoni O., Zheng, Ze, Ramakrishnan, Rajasekhar, Shi, Hongxue, Valenti, Luca, Pajvani, Utpal B., Sandhu, Jaspreet, Infante, Rodney E., Radhakrishnan, Arun, Covey, Douglas F., Guan, Kun-Liang, Buck, Jochen, Levin, Lonny R., Tontonoz, Peter, Schwabe, Robert F., Tabas, Ira

“…Incomplete understanding of how hepatosteatosis transitions to fibrotic non-alcoholic steatohepatitis (NASH) has limited therapeutic options. Two molecules…”
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Multiple functional neurosteroid binding sites on GABAA receptors by Chen, Zi-Wei, Bracamontes, John R, Budelier, Melissa M, Germann, Allison L, Shin, Daniel J, Kathiresan, Krishnan, Qian, Ming-Xing, Manion, Brad, Cheng, Wayland W L, Reichert, David E, Akk, Gustav, Covey, Douglas F, Evers, Alex S

“…Neurosteroids are endogenous modulators of neuronal excitability and nervous system development and are being developed as anesthetic agents and treatments for…”
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Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling by Luchetti, Giovanni, Sircar, Ria, Kong, Jennifer H, Nachtergaele, Sigrid, Sagner, Andreas, Byrne, Eamon Fx, Covey, Douglas F, Siebold, Christian, Rohatgi, Rajat

“…Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We find that cholesterol is not just necessary but also sufficient to…”
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A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol by Izumi, Yukitoshi, Cashikar, Anil G, Krishnan, Kathiresan, Paul, Steven M, Covey, Douglas F, Mennerick, Steven J, Zorumski, Charles F

“…Inflammatory cells, including macrophages and microglia, synthesize and release the oxysterol 25-hydroxycholesterol (25HC), which has antiviral and…”
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Oxysterols are allosteric activators of the oncoprotein Smoothened by Nachtergaele, Sigrid, Mydock, Laurel K, Krishnan, Kathiresan, Rammohan, Jayan, Schlesinger, Paul H, Covey, Douglas F, Rohatgi, Rajat

“…20( S )-hydroxycholesterol binds to Smo at a site distinct from cyclopamine and activates signaling via an allosteric mechanism. A new alkyne oxysterol analog…”
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Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond by Zorumski, Charles F., Paul, Steven M., Covey, Douglas F., Mennerick, Steven

“…The recent FDA approval of the neurosteroid, brexanolone (allopregnanolone), as a treatment for women with postpartum depression, and successful trials of a…”
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Cholesterol accessibility at the ciliary membrane controls hedgehog signaling by Kinnebrew, Maia, Iverson, Ellen J, Patel, Bhaven B, Pusapati, Ganesh V, Kong, Jennifer H, Johnson, Kristen A, Luchetti, Giovanni, Eckert, Kaitlyn M, McDonald, Jeffrey G, Covey, Douglas F, Siebold, Christian, Radhakrishnan, Arun, Rohatgi, Rajat

“…Previously we proposed that transmission of the hedgehog signal across the plasma membrane by Smoothened is triggered by its interaction with cholesterol…”
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25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner by Wong, Man Ying, Lewis, Michael, Doherty, James J, Shi, Yang, Cashikar, Anil G, Amelianchik, Anna, Tymchuk, Svitlana, Sullivan, Patrick M, Qian, Mingxing, Covey, Douglas F, Petsko, Gregory A, Holtzman, David M, Paul, Steven M, Luo, Wenjie

“…Genome-wide association studies of Alzheimer's disease (AD) have implicated pathways related to lipid homeostasis and innate immunity in AD pathophysiology…”
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Neurosteroids mediate and modulate the effects of pro-inflammatory stimulation and toll-like receptors on hippocampal plasticity and learning by Izumi, Yukitoshi, O'Dell, Kazuko A, Cashikar, Anil G, Paul, Steven M, Covey, Douglas F, Mennerick, Steven J, Zorumski, Charles F

“…Pro-inflammatory changes contribute to multiple neuropsychiatric illnesses. Understanding how these changes are involved in illnesses and identifying…”
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Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders by Griffiths, William J., Yutuc, Eylan, Abdel-Khalik, Jonas, Crick, Peter J., Hearn, Thomas, Dickson, Alison, Bigger, Brian W., Hoi-Yee Wu, Teresa, Goenka, Anu, Ghosh, Arunabha, Jones, Simon A., Covey, Douglas F., Ory, Daniel S., Wang, Yuqin

“…Cholestane-3β,5α,6β-triol (3β,5α,6β-triol) is formed from cholestan-5,6-epoxide (5,6-EC) in a reaction catalysed by cholesterol epoxide hydrolase, following…”
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Stereospecific requirement of cholesterol in the function of the serotonin1A receptor by Jafurulla, Md, Rao, Bhagyashree D., Sreedevi, Sugunan, Ruysschaert, Jean-Marie, Covey, Douglas F., Chattopadhyay, Amitabha

“…The serotonin1A receptor is an important member of the G protein-coupled receptor (GPCR) family. It is involved in the generation and modulation of a variety…”
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Quantitative imaging of membrane contact sites for sterol transfer between endo-lysosomes and mitochondria in living cells by Juhl, Alice Dupont, Heegaard, Christian W., Werner, Stephan, Schneider, Gerd, Krishnan, Kathiresan, Covey, Douglas F., Wüstner, Daniel

“…Mitochondria receive cholesterol from late endosomes and lysosomes (LE/LYSs) or from the plasma membrane for production of oxysterols and steroid hormones…”
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Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling by Griffiths, Samuel C., Schwab, Rebekka A., El Omari, Kamel, Bishop, Benjamin, Iverson, Ellen J., Malinauskas, Tomas, Dubey, Ramin, Qian, Mingxing, Covey, Douglas F., Gilbert, Robert J. C., Rohatgi, Rajat, Siebold, Christian

“…Hedgehog (HH) morphogen signalling, crucial for cell growth and tissue patterning in animals, is initiated by the binding of dually lipidated HH ligands to…”
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The Structural Basis of Cholesterol Accessibility in Membranes by Olsen, Brett N., Bielska, Agata A., Lee, Tiffany, Daily, Michael D., Covey, Douglas F., Schlesinger, Paul H., Baker, Nathan A., Ory, Daniel S.

“…Although the majority of free cellular cholesterol is present in the plasma membrane, cholesterol homeostasis is principally regulated through sterol-sensing…”
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Development of a bile acid-based newborn screen for Niemann-Pick disease type C by Jiang, Xuntian, Sidhu, Rohini, Mydock-McGrane, Laurel, Hsu, Fong-Fu, Covey, Douglas F, Scherrer, David E, Earley, Brian, Gale, Sarah E, Farhat, Nicole Y, Porter, Forbes D, Dietzen, Dennis J, Orsini, Joseph J, Berry-Kravis, Elizabeth, Zhang, Xiaokui, Reunert, Janice, Marquardt, Thorsten, Runz, Heiko, Giugliani, Roberto, Schaffer, Jean E, Ory, Daniel S

“…Niemann-Pick disease type C (NPC) is a fatal, neurodegenerative, cholesterol storage disorder. With new therapeutics in clinical trials, it is imperative to…”
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