Detection and characterization of novel luchacoviruses, genus Alphacoronavirus , in saliva and feces of meso-carnivores in the northeastern United States

Several coronaviruses (CoVs) have been detected in domesticated, farmed, and wild meso-carnivores, causing a wide range of diseases and infecting diverse species, highlighting their important but understudied role in the epidemiology of these viruses. Assessing the viral diversity hosted in wildlife...

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Bibliographic Details
Published in:	Journal of virology Vol. 97; no. 11; p. e0082923
Main Authors:	Olarte-Castillo, Ximena A, Plimpton, Laura, McQueary, Holly, Sun, Yining, Yu, Y Tina, Cover, Sarah, Richardson, Amy N, Jin, Yuhan, Grenier, Jennifer K, Cummings, Kevin J, Bunting, Elizabeth, Diuk-Wasser, Maria, Needle, David, Schuler, Krysten, Stanhope, Michael J, Whittaker, Gary, Goodman, Laura B
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 30-11-2023
Subjects:	Alphacoronavirus - classification Alphacoronavirus - genetics Alphacoronavirus - isolation & purification Animals Animals, Domestic - virology Animals, Wild - virology Carnivora - virology Coronavirus Infections - epidemiology Coronavirus Infections - transmission Coronavirus Infections - veterinary Feces - virology Genetic Diversity and Evolution Host Microbial Interactions Humans New England - epidemiology Saliva - virology Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - metabolism Viral Zoonoses - transmission Viral Zoonoses - virology New England coronavirus genomics surveillance studies wildlife
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Summary:	Several coronaviruses (CoVs) have been detected in domesticated, farmed, and wild meso-carnivores, causing a wide range of diseases and infecting diverse species, highlighting their important but understudied role in the epidemiology of these viruses. Assessing the viral diversity hosted in wildlife species is essential to understand their significance in the cross-species transmission of CoVs. Our focus here was on CoV discovery in meso-carnivores in the Northeast United States as a potential "hotspot" area with high density of humans and urban wildlife. This study identifies novel alphacoronaviruses circulating in multiple free-ranging wild and domestic species in this area and explores their potential epidemiological importance based on regions of the Spike gene, which are relevant for virus-host interactions.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 The authors declare no conflict of interest.
ISSN:	0022-538X 1098-5514 1098-5514
DOI:	10.1128/jvi.00829-23