Search Results - "Couturier, Julien"
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Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo
Published in Acta neuropathologica (01-04-2019)“…Brains of Alzheimer’s disease patients are characterized by the presence of amyloid plaques and neurofibrillary tangles, both invariably associated with…”
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A la carte dissolution of rare earth elements from lateritic and karstic bauxite residues at mild pH: Toward sustainable extraction processes
Published in Next Sustainability (2025)“…Recovery of rare earth elements from bauxite residues of lateritic versus karstic origin was explored at a pH ranging between 2.7 and 4.5 using a mixture of…”
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Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease
Published in The FASEB journal (01-06-2014)“…ABSTRACT Tau alterations are now considered an executor of neuronal demise and cognitive dysfunction in Alzheimer's disease (AD). Mouse models combining…”
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PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease
Published in Journal of cellular and molecular medicine (01-08-2009)“…• Introduction • Control of translation • Dysfunctions of protein synthesis mediated by PKR‐ and mTOR‐dependent signalling pathways • Crosslink between the…”
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Evidence of molecular links between PKR and mTOR signalling pathways in Aβ neurotoxicity: Role of p53, Redd1 and TSC2
Published in Neurobiology of disease (01-10-2009)“…Abstract The control of translation is disturbed in Alzheimer's disease (AD). This study analysed the crosslink between the up regulation of double-stranded…”
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Life cycle inventory of plastics losses from seafood supply chains: Methodology and application to French fish products
Published in The Science of the total environment (15-01-2022)“…Plastic debris into the environment is a growing threat for the ecosystems and human health. The seafood sector is particularly concerned because it generates…”
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Highly efficient diluent-free solvent extraction of uranium using mixtures of protonated trioctylamine and quaternary ammonium salts. Comparative Life Cycle Assessment with the conventional extractant
Published in Hydrometallurgy (01-02-2024)“…A more environmentally friendly solvent extraction process was formulated for uranium extraction using diluent-free extractants based on trialkylammonium…”
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Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease
Published in Journal of neuroinflammation (27-01-2016)“…The proinflammatory cytokine interleukin-1β (IL-1β) is overexpressed in Alzheimer disease (AD) as a key regulator of neuroinflammation. Amyloid-β (Aβ) peptide…”
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Yttrium speciation variability in bauxite residues of various origins, ages and storage conditions
Published in Journal of hazardous materials (15-02-2024)“…Bauxite residues (BRs) are highly alkaline wastes generated during alumina production from bauxite ore. Billions of tons have been accumulating worldwide for…”
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Interaction of Double-stranded RNA-dependent Protein Kinase (PKR) with the Death Receptor Signaling Pathway in Amyloid β (Aβ)-treated Cells and in APPSLPS1 Knock-in Mice
Published in The Journal of biological chemistry (08-01-2010)“…For 10 years, research has focused on signaling pathways controlling translation to explain neuronal death in Alzheimer Disease (AD). Previous studies…”
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Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures
Published in Journal of neuroinflammation (23-06-2011)“…Inflammation may be involved in the pathogenesis of Alzheimer's disease (AD). There has been little success with anti-inflammatory drugs in AD, while the…”
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Inhibition of double-stranded RNA-dependent protein kinase strongly decreases cytokine production and release in peripheral blood mononuclear cells from patients with Alzheimer's disease
Published in Journal of Alzheimer's disease (01-01-2010)“…Alzheimer's disease (AD), a neurodegenerative disorder, is the most common form of dementia in the elderly individuals. Among the pathogenic mechanisms in AD,…”
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13
Interaction of Double-stranded RNA-dependent Protein Kinase (PKR) with the Death Receptor Signaling Pathway in Amyloid β (Aβ)-treated Cells and in APPSLPS1 Knock-in Mice
Published in The Journal of biological chemistry (08-01-2010)“…For 10 years, research has focused on signaling pathways controlling translation to explain neuronal death in Alzheimer Disease (AD). Previous studies…”
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14
Interaction of Double-stranded RNA-dependent Protein Kinase (PKR) with the Death Receptor Signaling Pathway in Amyloid b (Ab)-treated Cells and in APPSLPS1 Knock-in Mice
Published in The Journal of biological chemistry (01-01-2010)“…For 10 years, research has focused on signaling pathways controlling translation to explain neuronal death in Alzheimer Disease (AD). Previous studies…”
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15
P1‐033: AMYLOID‐INDUCED TAUOPATHY CONTRIBUTES TO SYNAPTIC AND COGNITIVE DEFICITS IN A TRANSGENIC MODEL FOR ALZHEIMER'S DISEASE
Published in Alzheimer's & dementia (01-07-2014)Get full text
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AMYLOID-INDUCED TAUOPATHY CONTRIBUTES TO SYNAPTIC AND COGNITIVE DEFICITS IN A TRANSGENIC MODEL FOR ALZHEIMER'S DISEASE
Published in Alzheimer's & dementia (01-07-2014)Get full text
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17
Evidence of molecular links between PKR and mTOR signalling pathways in Abeta neurotoxicity: role of p53, Redd1 and TSC2
Published in Neurobiology of disease (01-10-2009)“…The control of translation is disturbed in Alzheimer's disease (AD). This study analysed the crosslink between the up regulation of double-stranded…”
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avances en las POLÍTICAS DE INTEGRACIÓN de las cinematografías iberoamericanas / progrés des POLITIQUES D'INTÉGRATION des cinématographies ibéro-américaines
Published in Cinémas d'Amérique latine (01-01-2011)“…Los primeros acuerdos iberoamericanos de cooperación para la producción de cine datan de 1930. Con posterioridad festivales como Viña del Mar o La Habana y la…”
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Pharmacological inhibition of PKR in APPswePS1dE9 mice transiently prevents inflammation at 12 months of age but increases Aβ42 levels in the late stages of the Alzheimer's disease
Published in Current Alzheimer research (01-03-2012)“…The double-stranded RNA-dependent protein kinase (PKR) is switched on by a wide range of stimuli, including the amyloid peptide. Then, PKR transmits signals to…”
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