Search Results - "Coutts, Alexander"

Myosin Vb Traffics P-Glycoprotein to the Apical Membrane of Intestinal Epithelial Cells by Dooley, Sarah A., Kolobova, Elena, Burman, Andreanna, Kaji, Izumi, Digrazia, Jessica R., Stubler, Rachel, Goldstein, Anna, Packirisamy, Charulekha, Coutts, Alexander W., Saqui-Salces, Milena, Gao, Nan, Engevik, Melinda A., Shub, Mitchell D., Goldenring, James R., Engevik, Amy C.

“…The xenobiotic efflux pump P-glycoprotein is highly expressed on the apical membrane of the gastrointestinal tract, where it regulates the levels of…”
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Editing Myosin VB Gene to Create Porcine Model of Microvillus Inclusion Disease, With Microvillus-Lined Inclusions and Alterations in Sodium Transporters by Engevik, Amy C., Coutts, Alexander W., Kaji, Izumi, Rodriguez, Paula, Ongaratto, Felipe, Saqui-Salces, Milena, Medida, Ramya Lekha, Meyer, Anne R., Kolobova, Elena, Engevik, Melinda A., Williams, Janice A., Shub, Mitchell D., Carlson, Daniel F., Melkamu, Tamene, Goldenring, James R.

“…Microvillus inclusion disease (MVID) is caused by inactivating mutations in the myosin VB gene (MYO5B). MVID is a complex disorder characterized by chronic,…”
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CRISPR/Cas9-editing of KISS1 to generate pigs with hypogonadotropic hypogonadism as a castration free trait by Flórez, Julio M, Martins, Kyra, Solin, Staci, Bostrom, Jonathan R, Rodríguez-Villamil, Paula, Ongaratto, Felipe, Larson, Sabreena A, Ganbaatar, Uyanga, Coutts, Alexander W, Kern, Doug, Murphy, Thomas W, Kim, Eui-Soo, Carlson, Daniel F, Huisman, Abe, Sonstegard, Tad S, Lents, Clay A

“…Most male pigs are surgically castrated to avoid puberty-derived boar taint and aggressiveness. However, this surgical intervention represents a welfare…”
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Good news and bad news are still news: experimental evidence on belief updating by Coutts, Alexander

“…Bayesian updating remains the benchmark for dynamic modeling under uncertainty within economics. Recent theory and evidence suggest individuals may process…”
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Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1 by Isakson, Sara H., Rizzardi, Anthony E., Coutts, Alexander W., Carlson, Daniel F., Kirstein, Mark N., Fisher, James, Vitte, Jeremie, Williams, Kyle B., Pluhar, G. Elizabeth, Dahiya, Sonika, Widemann, Brigitte C., Dombi, Eva, Rizvi, Tilat, Ratner, Nancy, Messiaen, Ludwine, Stemmer-Rachamimov, Anat O., Fahrenkrug, Scott C., Gutmann, David H., Giovannini, Marco, Moertel, Christopher L., Largaespada, David A., Watson, Adrienne L.

“…Neurofibromatosis Type 1 (NF1) is a genetic disease caused by mutations in Neurofibromin 1 ( NF1 ). NF1 patients present with a variety of clinical…”
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Recruitment of Polarity Complexes and Tight Junction Proteins to the Site of Apical Bulk Endocytosis by Engevik, Amy C., Krystofiak, Evan S., Kaji, Izumi, Meyer, Anne R., Weis, Victoria G., Goldstein, Anna, Coutts, Alexander W., Melkamu, Tamene, Saqui-Salces, Milena, Goldenring, James R.

“…The molecular motor, Myosin Vb (MYO5B), is well documented for its role in trafficking cargo to the apical membrane of epithelial cells. Despite its…”
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The age of consequences: Unraveling conflict's impact on social preferences, norm enforcement, and risk-taking by Coutts, Alexander

“…Beyond the direct destructive nature of war, conflict may also impact social preferences, norms, and risk-taking behavior. This paper examines the enduring…”
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Identifying communication spillovers in lab-in-the-field experiments by Coutts, Alexander

“…Use of lab-in-the-field experiments has steadily increased, given benefits of studying relevant populations and their preferences. In the field, researchers…”
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Selumetinib normalizes Ras/MAPK signaling in clinically relevant neurofibromatosis type 1 minipig tissues in vivo by Osum, Sara H, Coutts, Alexander W, Duerre, Dylan J, Tschida, Barbara R, Kirstein, Mark N, Fisher, James, Bell, W Robert, Delpuech, Oona, Smith, Paul D, Widemann, Brigitte C, Moertel, Christopher L, Largaespada, David A, Watson, Adrienne L

“…Abstract Background The MEK1/2 inhibitor selumetinib was recently approved for neurofibromatosis type 1 (NF1)-associated plexiform neurofibromas, but outcomes…”
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Testing models of belief bias: An experiment by Coutts, Alexander

“…Optimistic beliefs affect important areas of economic decision making, yet direct knowledge on how belief biases operate remains limited. To better understand…”
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What to Blame? Self-Serving Attribution Bias with Multi-Dimensional Uncertainty by Coutts, Alexander, Gerhards, Leonie, Murad, Zahra

“…Abstract People often receive feedback influenced by external factors, yet little is known about how this affects self-serving biases. Our theoretical model…”
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Does Information Break the Political Resource Curse? Experimental Evidence from Mozambique by Armand, Alex, Coutts, Alexander, Vicente, Pedro C., Vilela, Inês

“…Natural resources can have a negative impact on the economy through corruption and civil conflict. This paper tests whether information can counteract this…”
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Measuring corruption in the field using behavioral games by Armand, Alex, Coutts, Alexander, Vicente, Pedro C., Vilela, Inês

“…•We design a novel game to study corruption at local levels•We conduct the game in Northern Mozambique: Citizens play with their political leader.•Contrary to…”
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TMOD-03. A SWINE MODEL OF GLIOBLASTOMA INDUCED BY SOMATIC GENE MODIFICATION by Taisto, Mandy, Tschida, Barbara, Coutts, Alexander, Campbell, Jarryd, Corbiere, Stanislas, Duerre, Dylan, Watson, Adrienne

“…Abstract Glioblastoma (GBM) is the most common and malignant primary brain tumor. Novel therapeutic development for GBM is desperately needed, as the standard…”
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A comparison of visual and molecular methods for inferring biological communities in aquaculture enriched sediments - Impact assessment and cost-benefit analysis by Coutts, Alexander, Zimmermann, Danielle, Davey, Adam, Bowman, John P., Ross, Donald J., Strain, Elisabeth M.A.

“…Nutrients introduced to the environment by finfish aquaculture pose environmental risks, which can be mitigated by robust environmental monitoring. Biological…”
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Characterization of Porcine Models of Autosomal Recessive Polycystic Kidney Disease: PO1517 by Smith, Jessica M., Coutts, Alexander W., Tschida, Barbara R., Wells, Harrison H., Carlson, Daniel F., Harris, Peter C.

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Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs by Schneider, Jay W., Oommen, Saji, Qureshi, Muhammad Y., Goetsch, Sean C., Pease, David R., Sundsbak, Rhianna S., Guo, Wei, Sun, Mingming, Sun, Han, Kuroyanagi, Hidehito, Webster, Dennis A., Coutts, Alexander W., Holst, Kimberly A., Edwards, Brooks S., Newville, Nikolas, Hathcock, Matthew A., Melkamu, Tamene, Briganti, Francesca, Wei, Wu, Romanelli, Maria G., Fahrenkrug, Scott C., Frantz, Doug E., Olson, Timothy M., Steinmetz, Lars M., Carlson, Daniel F., Nelson, Timothy J.

“…Ribonucleoprotein (RNP) granules are biomolecular condensates—liquid–liquid phase-separated droplets that organize and manage messenger RNA metabolism, cell…”
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Sa119 RECRUITMENT OF POLARITY COMPLEXES AND TIGHT JUNCTION PROTEINS TO THE SITE OF APICAL BULK ENDOCYTOSIS by Engevik, Amy C., Krystofiak, Evan, Meyer, Anne R., Kaji, Izumi, Weis, Victoria G., Goldstein, Anna E., Coutts, Alexander W., Melkamu, Tamene, Saqui-Salces, Milena, Goldenring, James R.

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An environmental DNA approach to informing restoration of the functionally extinct oyster, Ostrea angasi by Coutts, Alexander, O'Brien, Allyson, Weeks, Andrew R., Swearer, Stephen E., Rooyen, Anthony, Branigan, Simon, Morris, Rebecca L.

“…The success of oyster reef restoration can be enhanced by data on the distribution of remnant populations to inform the selection of suitable restoration…”
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A PNPLA3 I148M gene‐edited Ossabaw swine model of Nonalcoholic steatohepatitis (NASH) by Coutts, Alexander W., Webster, Dennis A., Chen, Jun, Liang, Tiebing, Dasgupta, Debanjali, Ferreira, Matthew, Alloosh, Mouhamad, Flynn, Charles R., Cummings, Oscar, Carlson, Daniel F., Malhi, Harmeet, Sturek, Michael S., Chalasani, Naga, Melkamu, Tamene

“…Abstract only Nonalcoholic steatohepatitis (NASH) is an advanced form of nonalcoholic fatty liver disease (NAFLD), resulting from the complex interplay of…”
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