Search Results - "Couttet, Philippe"

Perturbation of microRNAs in rat heart during chronic doxorubicin treatment by Vacchi-Suzzi, Caterina, Bauer, Yasmina, Berridge, Brian R, Bongiovanni, Sandrine, Gerrish, Kevin, Hamadeh, Hisham K, Letzkus, Martin, Lyon, Jonathan, Moggs, Jonathan, Paules, Richard S, Pognan, François, Staedtler, Frank, Vidgeon-Hart, Martin P, Grenet, Olivier, Couttet, Philippe

“…Anti-cancer therapy based on anthracyclines (DNA intercalating Topoisomerase II inhibitors) is limited by adverse effects of these compounds on the…”
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Imaging Mass Cytometry and Single-Cell Genomics Reveal Differential Depletion and Repletion of B-Cell Populations Following Ofatumumab Treatment in Cynomolgus Monkeys by Theil, Diethilde, Smith, Paul, Huck, Catherine, Gilbart, Yoann, Kakarieka, Algirdas, Leppert, David, Rauld, Celine, Schmid, Cindy, Baumgartner, Reto, Stuber, Nathalie, Cordoba, Francisco, Dubost, Valerie, Darribat, Katy, Jivkov, Magali, Frieauff, Wilfried, Kneuer, Rainer, Stoeckli, Markus, Reinker, Stefan, Mansfield, Keith, Carballido, José M, Couttet, Philippe, Weckbecker, Gisbert

“…Ofatumumab is the first, fully human, anti-CD20 monoclonal antibody in Phase 3 development for multiple sclerosis (MS). The study focused on changes in…”
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Heart structure-specific transcriptomic atlas reveals conserved microRNA-mRNA interactions by Vacchi-Suzzi, Caterina, Hahne, Florian, Scheubel, Philippe, Marcellin, Magali, Dubost, Valerie, Westphal, Magdalena, Boeglen, Catherine, Büchmann-Møller, Stine, Cheung, Ming Sin, Cordier, André, De Benedetto, Christopher, Deurinck, Mark, Frei, Moritz, Moulin, Pierre, Oakeley, Edward, Grenet, Olivier, Grevot, Armelle, Stull, Robert, Theil, Diethilde, Moggs, Jonathan G, Marrer, Estelle, Couttet, Philippe

“…MicroRNAs are short non-coding RNAs that regulate gene expression at the post-transcriptional level and play key roles in heart development and cardiovascular…”
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Phenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice by Lempiäinen, Harri, Müller, Arne, Brasa, Sarah, Teo, Soon-Siong, Roloff, Tim-Christoph, Morawiec, Laurent, Zamurovic, Natasa, Vicart, Axel, Funhoff, Enrico, Couttet, Philippe, Schübeler, Dirk, Grenet, Olivier, Marlowe, Jennifer, Moggs, Jonathan, Terranova, Rémi

“…Evidence suggests that epigenetic perturbations are involved in the adverse effects associated with some drugs and toxicants, including certain classes of…”
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Liver enzyme delayed clearance in rat treated by CSF1 receptor specific antagonist Sotuletinib by Pognan, François, Buono, Chiara, Couttet, Philippe, Galarneau, Jean-René, Timsit, Yoav, Wolf, Armin

“…[Display omitted] •CSF1-R specific inhibitor Sotuletinib raises liver enzymes without hepatotoxicity.•Sotuletinib inhibition of CSF1-R leads to significant…”
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Identification of Dlk1-Dio3 imprinted gene cluster noncoding RNAs as novel candidate biomarkers for liver tumor promotion by Lempiäinen, Harri, Couttet, Philippe, Bolognani, Federico, Müller, Arne, Dubost, Valérie, Luisier, Raphaëlle, Del Rio Espinola, Alberto, Vitry, Veronique, Unterberger, Elif B, Thomson, John P, Treindl, Fridolin, Metzger, Ute, Wrzodek, Clemens, Hahne, Florian, Zollinger, Tulipan, Brasa, Sarah, Kalteis, Magdalena, Marcellin, Magali, Giudicelli, Fanny, Braeuning, Albert, Morawiec, Laurent, Zamurovic, Natasa, Längle, Ulrich, Scheer, Nico, Schübeler, Dirk, Goodman, Jay, Chibout, Salah-Dine, Marlowe, Jennifer, Theil, Diethilde, Heard, David J, Grenet, Olivier, Zell, Andreas, Templin, Markus F, Meehan, Richard R, Wolf, Roland C, Elcombe, Clifford R, Schwarz, Michael, Moulin, Pierre, Terranova, Rémi, Moggs, Jonathan G

“…The molecular events during nongenotoxic carcinogenesis and their temporal order are poorly understood but thought to include long-lasting perturbations of…”
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Two approaches for estimating the lower limit of quantitation (LLOQ) of microRNA levels assayed as exploratory biomarkers by RT-qPCR by Wolfinger, Russell D, Beedanagari, Sudheer, Boitier, Eric, Chen, Tao, Couttet, Philippe, Ellinger-Ziegelbauer, Heidrun, Guillemain, Gregory, Mariet, Claire, Mouritzen, Peter, O'Lone, Raegan, Pine, P Scott, Sharapova, Tatiana, Yan, Jian, Yuen, Peter S, Thompson, Karol L

“…Circulating microRNAs are undergoing exploratory use as safety biomarkers in drug development. Reverse transcription quantitative polymerase chain reaction…”
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Angiopoietin-2 is a direct transcriptional target of TAL1, LYL1 and LMO2 in endothelial cells by Deleuze, Virginie, El-Hajj, Rawan, Chalhoub, Elias, Dohet, Christiane, Pinet, Valérie, Couttet, Philippe, Mathieu, Danièle

“…The two related basic helix-loop-helix, TAL1 and LYL1, and their cofactor LIM-only-2 protein (LMO2) are present in blood and endothelial cells. While their…”
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LYL1 activity is required for the maturation of newly formed blood vessels in adulthood by Pirot, Nelly, Deleuze, Virginie, El-Hajj, Rawan, Dohet, Christiane, Sablitzky, Fred, Couttet, Philippe, Mathieu, Danièle, Pinet, Valérie

“…The 2 related basic helix loop helix genes, LYL1 and TAL-1 are active in hematopoietic and endothelial lineages. While Tal-1 is essential for both…”
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Bile Acid Sequestration by Cholestyramine Mitigates FGFR4 Inhibition-Induced ALT Elevation by Schadt, Heiko S, Wolf, Armin, Mahl, Joerg Andreas, Wuersch, Kuno, Couttet, Philippe, Schwald, Marianne, Fischer, Audrey, Lienard, Mathilde, Emotte, Corinne, Teng, Chi-Hse, Skuba, Elizabeth, Richardson, Terrilyn A, Manenti, Luigi, Weiss, Andreas, Graus Porta, Diana, Fairhurst, Robin A, Kullak-Ublick, Gerd A, Chibout, Salah-Dine, Pognan, Francois, Kluwe, William, Kinyamu-Akunda, Jacqueline

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Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors by Luisier, Raphaëlle, Lempiäinen, Harri, Scherbichler, Nina, Braeuning, Albert, Geissler, Miriam, Dubost, Valerie, Müller, Arne, Scheer, Nico, Chibout, Salah-Dine, Hara, Hisanori, Picard, Frank, Theil, Diethilde, Couttet, Philippe, Vitobello, Antonio, Grenet, Olivier, Grasl-Kraupp, Bettina, Ellinger-Ziegelbauer, Heidrun, Thomson, John P., Meehan, Richard R., Elcombe, Clifford R., Henderson, Colin J., Wolf, C. Roland, Schwarz, Michael, Moulin, Pierre, Terranova, Rémi, Moggs, Jonathan G.

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Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4 by Fairhurst, Robin A, Knoepfel, Thomas, Buschmann, Nicole, Leblanc, Catherine, Mah, Robert, Todorov, Milen, Nimsgern, Pierre, Ripoche, Sebastien, Niklaus, Michel, Warin, Nicolas, Luu, Van Huy, Madoerin, Mario, Wirth, Jasmin, Graus-Porta, Diana, Weiss, Andreas, Kiffe, Michael, Wartmann, Markus, Kinyamu-Akunda, Jacqueline, Sterker, Dario, Stamm, Christelle, Adler, Flavia, Buhles, Alexandra, Schadt, Heiko, Couttet, Philippe, Blank, Jutta, Galuba, Inga, Trappe, Jörg, Voshol, Johannes, Ostermann, Nils, Zou, Chao, Berghausen, Jörg, Del Rio Espinola, Alberto, Jahnke, Wolfgang, Furet, Pascal

“…FGF19 signaling through the FGFR4/β-klotho receptor complex has been shown to be a key driver of growth and survival in a subset of hepatocellular carcinomas,…”
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FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer by Weiss, Andreas, Adler, Flavia, Buhles, Alexandra, Stamm, Christelle, Fairhurst, Robin A, Kiffe, Michael, Sterker, Dario, Centeleghe, Mario, Wartmann, Markus, Kinyamu-Akunda, Jacqueline, Schadt, Heiko S, Couttet, Philippe, Wolf, Armin, Wang, Youzhen, Barzaghi-Rinaudo, Patrizia, Murakami, Masato, Kauffmann, Audrey, Knoepfel, Thomas, Buschmann, Nicole, Leblanc, Catherine, Mah, Robert, Furet, Pascal, Blank, Jutta, Hofmann, Francesco, Sellers, William R, Graus Porta, Diana

“…Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and it is the third leading cause of cancer-related deaths worldwide…”
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Requirement of bic/microRNA-155 for Normal Immune Function by Rodriguez, Antony, Vigorito, Elena, Clare, Simon, Warren, Madhuri V, Couttet, Philippe, Soond, Dalya R, van Dongen, Stijn, Grocock, Russell J, Das, Partha P, Miska, Eric A, Vetrie, David, Okkenhaug, Klaus, Enright, Anton J, Dougan, Gordon, Turner, Martin, Bradley, Allan

“…MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are…”
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Evaluation of transcriptomic signature as a valuable tool to study drug-induced cholestasis in primary human hepatocytes by Parmentier, Céline, Couttet, Philippe, Wolf, Armin, Zaccharias, Thomas, Heyd, Bruno, Bachellier, Philippe, Uteng, Marianne, Richert, Lysiane

“…Primary human hepatocyte (PHH) sandwich cultures from five different donors were daily exposed to cyclosporine A (CsA), ibuprofen (IBU), chlorpromazine (CPZ),…”
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Identification of marker genes to monitor residual iPSCs in iPSC-derived products by Lemmens, Myriam, Perner, Juliane, Potgeter, Leon, Zogg, Michael, Thiruchelvam, Sineha, Müller, Matthias, Doll, Thierry, Werner, Annick, Gilbart, Yoann, Couttet, Philippe, Martus, Hans-Jörg, Libertini, Silvana

“…Engineered tissues and cell therapies based on human induced pluripotent stem cells (iPSCs) represent a promising approach for novel medicines. However,…”
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Transcriptomic Analysis of Cholestatic Compounds In Vitro by Parmentier, Céline, Couttet, Philippe, Uteng, Marianne, Wolf, Armin, Richert, Lysiane

“…Drug-induced cholestasis is one of the most severe manifestations of drug-induced liver injury. Drug-induced cholestasis is characterized by an accumulation of…”
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Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo by Velcicky, Juraj, Bodendorf, Ursula, Rigollier, Pascal, Epple, Robert, Beisner, Daniel R, Guerini, Danilo, Smith, Philip, Liu, Bo, Feifel, Roland, Wipfli, Peter, Aichholz, Reiner, Couttet, Philippe, Dix, Ina, Widmer, Toni, Wen, Ben, Brandl, Trixi

“…Signal peptide peptidase-like 2a (SPPL2a) is an aspartic intramembrane protease which has recently been shown to play an important role in the development and…”
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Methodological considerations for measuring biofluid-based microRNA biomarkers by Chorley, Brian N., Atabakhsh, Elnaz, Doran, Graeme, Gautier, Jean-Charles, Ellinger-Ziegelbauer, Heidrun, Jackson, David, Sharapova, Tatiana, Yuen, Peter S.T., Church, Rachel J., Couttet, Philippe, Froetschl, Roland, McDuffie, James, Martinez, Victor, Pande, Parimal, Peel, Lauren, Rafferty, Conor, Simutis, Frank J., Harrill, Alison H.

“…MicroRNAs (miRNAs) are small non-coding RNA that regulate the expression of messenger RNA and are implicated in almost all cellular processes. Importantly,…”
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Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin by Brecht, Karin, Riebel, Virginie, Couttet, Philippe, Paech, Franziska, Wolf, Armin, Chibout, Salah-Dine, Pognan, Francois, Krähenbühl, Stephan, Uteng, Marianne

“…Arctigenin has previously been identified as a potential anti-tumor treatment for advanced pancreatic cancer. However, the mechanism of how arctigenin kills…”
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