Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis

Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis

Leptospirosis is a zoonotic disease that causes severe manifestations such as Weil's disease and pulmonary hemorrhage syndrome. The aim of this study was to evaluate whether reactive oxygen species (ROS) production and antioxidant reduced glutathione (GSH) levels are related to complications in...

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Bibliographic Details
Published in:The American journal of tropical medicine and hygiene Vol. 90; no. 4; pp. 719 - 723
Main Authors: Araújo, Alan M, Reis, Eliana A G, Athanazio, Daniel A, Ribeiro, Guilherme S, Hagan, José E, Araujo, Guilherme C, Damião, Alcineia O, Couto, Nicolli S, Ko, Albert I, Noronha-Dutra, Alberto, Reis, Mitermayer G
Format: Journal Article
Language:English
Published: United States The American Society of Tropical Medicine and Hygiene 01-04-2014
Subjects:
Acute Kidney Injury - blood
Adolescent
Adult
Biomarkers - blood
Case-Control Studies
Cohort Studies
Creatinine - blood
Female
Glutathione - blood
Humans
Leptospira
Leptospirosis - blood
Male
Middle Aged
Oxidative Stress
Potassium - blood
Reactive Oxygen Species - blood
Severity of Illness Index
Thrombocytopenia - blood
Young Adult
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Summary:Leptospirosis is a zoonotic disease that causes severe manifestations such as Weil's disease and pulmonary hemorrhage syndrome. The aim of this study was to evaluate whether reactive oxygen species (ROS) production and antioxidant reduced glutathione (GSH) levels are related to complications in patients hospitalized with leptospirosis. The ROS production and GSH levels were measured in blood samples of 12 patients and nine healthy controls using chemiluminescence and absorbance assays. We found that ROS production was higher and GSH levels were lower in leptospirosis patients compared with healthy individuals. Among patients, GSH depletion was correlated with thrombocytopenia and elevated serum creatinine, whereas a strong positive correlation was observed between ROS production and elevated serum potassium. Additional investigation of the biological significance of ROS production and GSH levels is warranted as they may guide the development of novel adjuvant therapies for leptospirosis targeting oxidative stress.
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ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.13-0667