Search Results - "Coutinho, S V"

Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat by Coutinho, S V, Plotsky, P M, Sablad, M, Miller, J C, Zhou, H, Bayati, A I, McRoberts, J A, Mayer, E A

“…This study investigated the combined effect of neonatal maternal separation and acute psychological stress on pain responses in adult rats. Long-Evans dams and…”
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Role of glutamate receptors and nitric oxide in the rostral ventromedial medulla in visceral hyperalgesia by Coutinho, V S, Urban, O M, Gebhart, F G

“…The present study was undertaken to examine the involvement of descending pain modulatory systems from the brainstem rostral ventromedial medulla (RVM) in…”
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CRF2 receptor activation prevents colorectal distension induced visceral pain and spinal ERK1/2 phosphorylation in rats by Million, M, Wang, L, Wang, Y, Adelson, D W, Yuan, P-Q, Maillot, C, Coutinho, S V, Mcroberts, J A, Bayati, A, Mattsson, H, Wu, V, Wei, J-Y, Rivier, J, Vale, W, Mayer, E A, Taché, Y

“…Background and aims: Activation of corticotropin releasing factor 1 (CRF1) receptors is involved in stress related responses and visceral pain, while…”
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Involvement of excitatory amino acid receptors and nitric oxide in the rostral ventromedial medulla in modulating secondary hyperalgesia produced by mustard oil by Urban, M O, Coutinho, S V, Gebhart, G F

“…We have recently reported a model of secondary hyperalgesia in which facilitation of the thermal nociceptive tail-flick reflex following topical mustard oil is…”
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Intracolonic zymosan produces visceral hyperalgesia in the rat that is mediated by spinal NMDA and non-NMDA receptors by Coutinho, S.V., Meller, S.T., Gebhart, G.F.

“…The present study examined the effects of colonic inflammation on reflex responses to colorectal distension (CRD) in awake rats. Visceromotor responses (VMR)…”
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Tributyltin chloride induces renal dysfunction by inflammation and oxidative stress in female rats by Coutinho, João V.S., Freitas-Lima, Leandro C., Freitas, Frederico F.C.T., Freitas, Flávia P.S., Podratz, Priscila L., Magnago, Rafaella P.L., Porto, Marcella L., Meyrelles, Silvana S., Vasquez, Elisardo C., Brandão, Poliane A.A., Carneiro, Maria T.W.D., Paiva-Melo, Francisca D., Miranda-Alves, Leandro, Silva, Ian V., Gava, Agata L., Graceli, Jones B.

“…[Display omitted] •TBT reduced GFR and increased proteinuria levels in female rats.•TBT increased renal mensagial expansion and collagen deposition.•TBT…”
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Biphasic modulation of visceral nociception by neurotensin in rat rostral ventromedial medulla by Urban, M O, Coutinho, S V, Gebhart, G F

“…A potential role for neurotensin in the rostral ventromedial medulla (RVM) in modulation of visceral nociceptive transmission was examined in this study…”
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A role for spinal nitric oxide in mediating visceral hyperalgesia in the rat by Coutinho, S.V., Gebhart, G.F.

“…Background & Aims: Intracolonic instillation of zymosan in rats produces hyperalgesia (i.e., facilitates the visceromotor response to colorectal distention)…”
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Involvement of spinal calcitonin gene‐related peptide in the development of acute visceral hyperalgesia in the rat by Gschossmann, J. M., Coutinho, S. V., Miller, J. C., Huebel, K., Naliboff, B., Wong, H. C., Walsh, J. H., Mayer, E. A.

“…This study aimed to characterize the role of the neuropeptide calcitonin gene‐related peptide (CGRP) in the development of mechanically induced visceral…”
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V. Stress and irritable bowel syndrome by Mayer, E A, Naliboff, B D, Chang, L, Coutinho, S V

“…Different types of stress play important roles in the onset and modulation of irritable bowel syndrome (IBS) symptoms. The physiological effects of…”
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Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats by McRoberts, James A., Coutinho, Santosh V., Marvizón, Juan Carlos G., Grady, Eileen F., Tognetto, Michele, Sengupta, Jyoti N., Ennes, Helena S., Chaban, Victor V., Amadesi, Silvia, Creminon, Christophe, Lanthorn, Tom, Geppetti, Pierangelo, Bunnett, Nigel W., Mayer, Emeran A.

“…Background & Aims:N-methyl-D-aspartate (NMDA) receptors are ligand-gated ion channels that have an important role in long-term potentiation and memory…”
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Successful outcome of montelukast overdosage in an asthmatic child by Geller, M, Melo, L R, Coutinho, S V

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Role of sensitized pelvic nerve afferents from the inflamed rat colon in the maintenance of visceral hyperalgesia by Coutinho, S V, Su, X, Sengupta, J N, Gebhart, G F

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Rationale, Design, and Synthesis of Novel Phenyl Imidazoles as Opioid Receptor Agonists for Gastrointestinal Disorders by Breslin, Henry J, Miskowski, Tamara A, Rafferty, Bryan M, Coutinho, Santosh V, Palmer, Jeffrey M, Wallace, Nathaniel H, Schneider, Craig R, Kimball, Edward S, Zhang, Sui-Po, Li, Jian, Colburn, Raymond W, Stone, Dennis J, Martinez, Rebecca P, He, Wei

“…A small series of novel, imidazoles 4 have been prepared that exhibit very good binding affinities for the δ and μ opioid receptors (ORs), as well as…”
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Mycosis fungoides with early central nervous system involvement by Filipe, P L, Coutinho, V S, Canhão, P, Gouveia, R, Cabeçadas, J, Osório, A, Antunes, J L

“…The authors present a rare case of mycosis fungoides with early central nervous system involvement mimicking an intramedullary tumour in a 38- year-old white…”
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Differential effects of chemical and mechanical colonic irritation on behavioral pain response to intraperitoneal acetic acid in mice by Martínez, V, Thakur, S, Mogil, J S, Taché, Y, Mayer, E A

“…Abdominal contractions are a viscerosomatic reflex response to noxious colorectal irritation in rats. In this study we characterize the modulating effect of…”
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Corticotropin-releasing factor receptor 1 mediates acute and delayed stress-induced visceral hyperalgesia in maternally separated Long-Evans rats by Schwetz, Ines, McRoberts, James A, Coutinho, Santosh V, Bradesi, Sylvie, Gale, Greg, Fanselow, Michael, Million, Mulugeta, Ohning, Gordon, Taché, Yvette, Plotsky, Paul M, Mayer, Emeran A

“…In rodents, maternal pup interactions play an important role in programming the stress responsiveness of the adult organism. The aims of this study were 1) to…”
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The role of CNS NMDA receptors and nitric oxide in visceral hyperalgesia by Coutinho, Santosh V, Urban, Mark O, Gebhart, G.F

“…The studies summarized here document the role of NMDA receptors and nitric oxide in the lumbosacral spinal cord and rostral ventromedial medulla in the…”
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CRF2 receptor activation prevents colorectal distension induced visceral pain and spinal ERK1/2 phosphorylation in rats. Commentary by FUKUDO, S, SAITO, K, COUTINHO, S. V, MCROBERTS, J. A, BAYATI, A, MATTSSON, H, WU, V, WEI, J.-Y, RIVIER, J, VALE, W, MAYER, E. A, TACHE, Y, SAGAMI, Y, KANAZAWA, M, MILLION, M, WANG, L, WANG, Y, ADELSON, D. W, YUAN, P.-Q, MAILLOT, C

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Identification of potent phenyl imidazoles as opioid receptor agonists by Breslin, Henry J., Cai, Chaozhong, Miskowski, Tamara A., Coutinho, Santosh V., Zhang, Sui-Po, Hornby, Pamela, He, Wei

“…Using previously reported opioid receptor (OR) agonist analogs 4a– c as starting points, the structure–activity relationship (SAR) for their related series has…”
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