Search Results - "Coutinho, Fiona"

A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression by Chen, Xin, Wanggou, Siyi, Bodalia, Ankur, Zhu, Min, Dong, Weifan, Fan, Jerry J., Yin, Wen Chi, Min, Hyun-Kee, Hu, Malini, Draghici, Diana, Dou, Wenkun, Li, Feng, Coutinho, Fiona J., Whetstone, Heather, Kushida, Michelle M., Dirks, Peter B., Song, Yuanquan, Hui, Chi-chung, Sun, Yu, Wang, Lu-Yang, Li, Xuejun, Huang, Xi

“…Alteration of tissue mechanical properties is a physical hallmark of solid tumors including gliomas. How tumor cells sense and regulate tissue mechanics is…”
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Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells by MacLeod, Graham, Bozek, Danielle A., Rajakulendran, Nishani, Monteiro, Vernon, Ahmadi, Moloud, Steinhart, Zachary, Kushida, Michelle M., Yu, Helen, Coutinho, Fiona J., Cavalli, Florence M.G., Restall, Ian, Hao, Xiaoguang, Hart, Traver, Luchman, H. Artee, Weiss, Samuel, Dirks, Peter B., Angers, Stephane

“…Glioblastoma therapies have remained elusive due to limitations in understanding mechanisms of growth and survival of the tumorigenic population. Using…”
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ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells by Park, Nicole I., Guilhamon, Paul, Desai, Kinjal, McAdam, Rochelle F., Langille, Ellen, O’Connor, Madlen, Lan, Xiaoyang, Whetstone, Heather, Coutinho, Fiona J., Vanner, Robert J., Ling, Erick, Prinos, Panagiotis, Lee, Lilian, Selvadurai, Hayden, Atwal, Gurnit, Kushida, Michelle, Clarke, Ian D., Voisin, Veronique, Cusimano, Michael D., Bernstein, Mark, Das, Sunit, Bader, Gary, Arrowsmith, Cheryl H., Angers, Stephane, Huang, Xi, Lupien, Mathieu, Dirks, Peter B.

“…Glioblastomas exhibit a hierarchical cellular organization, suggesting that they are driven by neoplastic stem cells that retain partial yet abnormal…”
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High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma by Johnston, Michael J, Nikolic, Ana, Ninkovic, Nicoletta, Guilhamon, Paul, Cavalli, Florence M G, Seaman, Steven, Zemp, Franz J, Lee, John, Abdelkareem, Aly, Ellestad, Katrina, Murison, Alex, Kushida, Michelle M, Coutinho, Fiona J, Ma, Yussanne, Mungall, Andrew J, Moore, Richard, Marra, Marco A, Taylor, Michael D, Dirks, Peter B, Pugh, Trevor J, Morrissy, Sorana, St Croix, Bradley, Mahoney, Douglas J, Lupien, Mathieu, Gallo, Marco

“…We investigated the role of 3D genome architecture in instructing functional properties of glioblastoma stem cells (GSCs) by generating sub-5-kb resolution 3D…”
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A Tumorigenic MLL-Homeobox Network in Human Glioblastoma Stem Cells by GALLO, Marco, HO, Jenny, COUTINHO, Fiona J, VANNER, Robert, LEE, Lilian, HEAD, Renee, LING, Erick K. M, CLARKE, Ian D, DIRKS, Peter B

“…Glioblastoma growth is driven by cancer cells that have stem cell properties, but molecular determinants of their tumorigenic behavior are poorly defined. In…”
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Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity by Richards, Laura M, Whitley, Owen K N, MacLeod, Graham, Cavalli, Florence M G, Coutinho, Fiona J, Jaramillo, Julia E, Svergun, Nataliia, Riverin, Mazdak, Croucher, Danielle C, Kushida, Michelle, Yu, Kenny, Guilhamon, Paul, Rastegar, Naghmeh, Ahmadi, Moloud, Bhatti, Jasmine K, Bozek, Danielle A, Li, Naijin, Lee, Lilian, Che, Clare, Luis, Erika, Park, Nicole I, Xu, Zhiyu, Ketela, Troy, Moore, Richard A, Marra, Marco A, Spears, Julian, Cusimano, Michael D, Das, Sunit, Bernstein, Mark, Haibe-Kains, Benjamin, Lupien, Mathieu, Luchman, H Artee, Weiss, Samuel, Angers, Stephane, Dirks, Peter B, Bader, Gary D, Pugh, Trevor J

“…Glioblastomas harbor diverse cell populations, including rare glioblastoma stem cells (GSCs) that drive tumorigenesis. To characterize functional diversity…”
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Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas by Isaev, Keren, Jiang, Lingyan, Wu, Shuai, Lee, Christian A., Watters, Valérie, Fort, Victoire, Tsai, Ricky, Coutinho, Fiona J., Hussein, Samer M.I., Zhang, Jie, Wu, Jinsong, Dirks, Peter B., Schramek, Daniel, Reimand, Jüri

“…Long non-coding RNAs (lncRNAs) are increasingly recognized as functional units in cancer and powerful biomarkers; however, most remain uncharacterized. Here,…”
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ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells by Park, Nicole I., Guilhamon, Paul, Desai, Kinjal, McAdam, Rochelle F., Langille, Ellen, O’Connor, Madlen, Lan, Xiaoyang, Whetstone, Heather, Coutinho, Fiona J., Vanner, Robert J., Ling, Erick, Prinos, Panagiotis, Lee, Lilian, Selvadurai, Hayden, Atwal, Gurnit, Kushida, Michelle, Clarke, Ian D., Voisin, Veronique, Cusimano, Michael D., Bernstein, Mark, Das, Sunit, Bader, Gary, Arrowsmith, Cheryl H., Angers, Stephane, Huang, Xi, Lupien, Mathieu, Dirks, Peter B.

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Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma by Hoffman, Mary, Gillmor, Aaron H, Kunz, Daniel J, Johnston, Michael J, Nikolic, Ana, Narta, Kiran, Zarrei, Mehdi, King, Jennifer, Ellestad, Katrina, Dang, Ngoc Ha, Cavalli, Florence M G, Kushida, Michelle M, Coutinho, Fiona J, Zhu, Yuankun, Luu, Betty, Ma, Yussanne, Mungall, Andrew J, Moore, Richard, Marra, Marco A, Taylor, Michael D, Pugh, Trevor J, Dirks, Peter B, Strother, Douglas, Lafay-Cousin, Lucie, Resnick, Adam C, Scherer, Stephen, Senger, Donna L, Simons, Benjamin D, Chan, Jennifer A, Morrissy, A Sorana, Gallo, Marco

“…Pediatric glioblastoma (pGBM) is a lethal cancer with no effective therapies. To understand the mechanisms of tumor evolution in this cancer, we performed…”
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Characterization of blaSHV Genes on Plasmids from Escherichia coli and Salmonella enterica Isolates from Canadian Food Animals (2006-2007) by Pouget, Jennie G, Coutinho, Fiona J, Reid-Smith, Richard J, Boerlin, Patrick

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Characterization of bla(SHV) genes on plasmids from Escherichia coli and Salmonella enterica isolates from Canadian food animals (2006-2007) by Pouget, Jennie G, Coutinho, Fiona J, Reid-Smith, Richard J, Boerlin, Patrick

“…bla(SHV) genes from Escherichia coli and Salmonella enterica isolates from chicken (n = 19) and pork (n = 1) were identified as bla(SHV-2) (n = 5) or…”
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Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival by Guilhamon, Paul, Chesnelong, Charles, Kushida, Michelle M, Nikolic, Ana, Singhal, Divya, MacLeod, Graham, Madani Tonekaboni, Seyed Ali, Cavalli, Florence Mg, Arlidge, Christopher, Rajakulendran, Nishani, Rastegar, Naghmeh, Hao, Xiaoguang, Hassam, Rozina, Smith, Laura J, Whetstone, Heather, Coutinho, Fiona J, Nadorp, Bettina, Ellestad, Katrina I, Luchman, H Artee, Chan, Jennifer Ai-Wen, Shoichet, Molly S, Taylor, Michael D, Haibe-Kains, Benjamin, Weiss, Samuel, Angers, Stephane, Gallo, Marco, Dirks, Peter B, Lupien, Mathieu

“…Chromatin accessibility discriminates stem from mature cell populations, enabling the identification of primitive stem-like cells in primary tumors, such as…”
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Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma by Michealraj, Kulandaimanuvel Antony, Kumar, Sachin A., Kim, Leo J.Y., Cavalli, Florence M.G., Przelicki, David, Wojcik, John B., Delaidelli, Alberto, Bajic, Andrea, Saulnier, Olivier, MacLeod, Graham, Vellanki, Ravi N., Vladoiu, Maria C., Guilhamon, Paul, Ong, Winnie, Lee, John J.Y., Jiang, Yanqing, Holgado, Borja L., Rasnitsyn, Alex, Malik, Ahmad A., Tsai, Ricky, Richman, Cory M., Juraschka, Kyle, Haapasalo, Joonas, Wang, Evan Y., De Antonellis, Pasqualino, Suzuki, Hiromichi, Farooq, Hamza, Balin, Polina, Kharas, Kaitlin, Van Ommeren, Randy, Sirbu, Olga, Rastan, Avesta, Krumholtz, Stacey L., Ly, Michelle, Ahmadi, Moloud, Deblois, Geneviève, Srikanthan, Dilakshan, Luu, Betty, Loukides, James, Wu, Xiaochong, Garzia, Livia, Ramaswamy, Vijay, Kanshin, Evgeny, Sánchez-Osuna, María, El-Hamamy, Ibrahim, Coutinho, Fiona J., Prinos, Panagiotis, Singh, Sheila, Donovan, Laura K., Daniels, Craig, Schramek, Daniel, Tyers, Mike, Weiss, Samuel, Stein, Lincoln D., Lupien, Mathieu, Wouters, Bradly G., Garcia, Benjamin A., Arrowsmith, Cheryl H., Sorensen, Poul H., Angers, Stephane, Jabado, Nada, Dirks, Peter B., Mack, Stephen C., Agnihotri, Sameer, Rich, Jeremy N., Taylor, Michael D.

“…Posterior fossa A (PFA) ependymomas are lethal malignancies of the hindbrain in infants and toddlers. Lacking highly recurrent somatic mutations, PFA…”
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CNSC-44. BIOLOGICAL PATTERN DISCOVERY IN GLIOBLASTOMA by Ayyadhury, Shamini, Sachamitr, Patty, Kushida, Michelle, Park, Nicole, Coutinho, Fiona, Whitley, Owen, Prinos, Panagiotis, Arrowsmith, Cheryl, Dirks, Peter, Pugh, Trevor, Bader, Gary

“…Abstract Glioblastoma(GBM - IDH wildtype) is an adult glioma, showing abysmal prognosis. Sequencing technologies show us the existence of a neurodevelopmental…”
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Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma by Vanner, Robert J., Remke, Marc, Gallo, Marco, Selvadurai, Hayden J., Coutinho, Fiona, Lee, Lilian, Kushida, Michelle, Head, Renee, Morrissy, Sorana, Zhu, Xueming, Aviv, Tzvi, Voisin, Veronique, Clarke, Ian D., Li, Yisu, Mungall, Andrew J., Moore, Richard A., Ma, Yussanne, Jones, Steven J.M., Marra, Marco A., Malkin, David, Northcott, Paul A., Kool, Marcel, Pfister, Stefan M., Bader, Gary, Hochedlinger, Konrad, Korshunov, Andrey, Taylor, Michael D., Dirks, Peter B.

“…Functional heterogeneity within tumors presents a significant therapeutic challenge. Here we show that quiescent, therapy-resistant Sox2+ cells propagate sonic…”
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Abstract 5724: Revelation of shared transcriptional gradients in glioblastoma tumors and cultured glioma stem cells by Whitley, Owen K., Richards, Laura M., Cavalli, Florence, Guilhamon, Paul, Coutinho, Fiona, Kushida, Michelle, Luchman, H. Artee, Weiss, Samuel, Lupien, Mathieu, Dirks, Peter, Pugh, Trevor, Bader, Gary

“…Abstract The brain tumor Glioblastoma (GBM) is a virtual death sentence for anyone who is diagnosed, with a median survival time of 12-15 months with standard…”
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Abstract 3058: Data and resource sharing: Advancing our understanding of glioblastoma by Luchman, Hema A., Coutinho, Fiona, Weiss, Samuel, Consortium, Stand Up to Cancer Stem Cell Dream Team, Dirks, Peter

“…Abstract Glioblastoma multiforme (GBM), characterized by an aggressive clinical course, therapeutic resistance, and striking molecular heterogeneity, remains…”
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Abstract 967: Single-cell transcriptomics uncovers clonal heterogeneity linked to drug response and cellular phenotype in adult brain tumor stem cells by Richards, Laura M., Whitley, Owen, Cavalli, Florence M., Safikhani, Zhaleh, Coutinho, Fiona, Luchman, H. Artee, Haibe-Kains, Benjamin, Weiss, Samuel, Dirks, Peter, Bader, Gary, Pugh, Trevor J.

“…Abstract Brain tumours remain a largely incurable disease, with glioblastoma multiforme (GBM) representing the predominant form of malignancy. GBMs contain a…”
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MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin by Gallo, Marco, Coutinho, Fiona J., Vanner, Robert J., Gayden, Tenzin, Mack, Stephen C., Murison, Alex, Remke, Marc, Li, Ren, Takayama, Naoya, Desai, Kinjal, Lee, Lilian, Lan, Xiaoyang, Park, Nicole I., Barsyte-Lovejoy, Dalia, Smil, David, Sturm, Dominik, Kushida, Michelle M., Head, Renee, Cusimano, Michael D., Bernstein, Mark, Clarke, Ian D., Dick, John E., Pfister, Stefan M., Rich, Jeremy N., Arrowsmith, Cheryl H., Taylor, Michael D., Jabado, Nada, Bazett-Jones, David P., Lupien, Mathieu, Dirks, Peter B.

“…Mutations in the histone 3 variant H3.3 have been identified in one-third of pediatric glioblastomas (GBMs), but not in adult tumors. Here we show that H3.3 is…”
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Characterization of bla SHV Genes on Plasmids from Escherichia coli and Salmonella enterica Isolates from Canadian Food Animals (2006-2007) by Pouget, Jennie G., Coutinho, Fiona J., Reid-Smith, Richard J., Boerlin, Patrick

“…ABSTRACT bla SHV genes from Escherichia coli and Salmonella enterica isolates from chicken ( n = 19) and pork ( n = 1) were identified as bla SHV-2 ( n = 5) or…”
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