Search Results - "Coussios, C."

Role of acoustic cavitation in the delivery and monitoring of cancer treatment by high-intensity focused ultrasound (HIFU) by Coussios, C C, Farny, C H, Haar, G Ter, Roy, R A

“…Acoustic cavitation has been shown to play a key role in a wide array of novel therapeutic ultrasound applications. This paper presents a brief discussion of…”
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Passive cavitation mapping for localization and tracking of bubble dynamics by Gyöngy, Miklós, Coussios, Constantin-C.

“…Current acoustic techniques for studying cavitation dynamics are only readily applicable to single-bubble activity, while optical methods can only be used in…”
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Preliminary Single‐Center Canadian Experience of Human Normothermic Ex Vivo Liver Perfusion: Results of a Clinical Trial by Bral, M., Gala‐Lopez, B., Bigam, D., Kneteman, N., Malcolm, A., Livingstone, S., Andres, A., Emamaullee, J., Russell, L., Coussios, C., West, L. J., Friend, P. J., Shapiro, A. M. J.

“…After extensive experimentation, outcomes of a first clinical normothermic machine perfusion (NMP) liver trial in the United Kingdom demonstrated feasibility…”
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Applications of Acoustics and Cavitation to Noninvasive Therapy and Drug Delivery by COUSSIOS, Constantin C, ROY, Ronald A

“…Biomedical acoustics is rapidly evolving from a diagnostic modality into a therapeutic tool, and acoustic cavitation is often the common denominator in a wide…”
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Passive Spatial Mapping of Inertial Cavitation During HIFU Exposure by Gyongy, Miklos, Coussios, Constantin-C.

“…A novel method for mapping inertial cavitation activity during high-intensity focused ultrasound (HIFU) exposure is presented. Inertial cavitation has been…”
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Passive acoustic mapping utilizing optimal beamforming in ultrasound therapy monitoring by Coviello, Christian, Kozick, Richard, Choi, James, Gyöngy, Miklós, Jensen, Carl, Smith, Penny Probert, Coussios, Constantin-C

“…Passive acoustic mapping (PAM) is a promising imaging method that enables real-time three-dimensional monitoring of ultrasound therapy through the…”
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Normothermic Machine Perfusion (NMP) Inhibits Proinflammatory Responses in the Liver and Promotes Regeneration by Jassem, Wayel, Xystrakis, Emmanuel, Ghnewa, Yasmeen G., Yuksel, Muhammed, Pop, Oltin, Martinez‐Llordella, Marc, Jabri, Yamen, Huang, Xiaohong, Lozano, Juan J., Quaglia, Alberto, Sanchez‐Fueyo, Alberto, Coussios, Constantin C., Rela, Mohamed, Friend, Peter, Heaton, Nigel, Ma, Yun

“…Liver transplantation (LT) is a successful treatment for patients with liver failure. However, organ shortage results in over 11% of patients losing their…”
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Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First‐in‐Man) Clinical Trial by Ravikumar, R., Jassem, W., Mergental, H., Heaton, N., Mirza, D., Perera, M. T. P. R., Quaglia, A., Holroyd, D., Vogel, T., Coussios, C. C., Friend, P. J.

“…The number of donor organs suitable for liver transplantation is restricted by cold preservation and ischemia–reperfusion injury. We present the first patients…”
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Noninvasive assessment of steatosis and viability of cold‐stored human liver grafts by MRI by Young, Liam A. J., Ceresa, Carlo D. L., Mózes, Ferenc E., Ellis, Jane, Valkovič, Ladislav, Colling, Richard, Coussios, Constantin‐C., Friend, Peter J., Rodgers, Christopher T.

“…Purpose A shortage of suitable donor livers is driving increased use of higher risk livers for transplantation. However, current biomarkers are not sensitive…”
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Enhanced Tumor Uptake and Penetration of Virotherapy Using Polymer Stealthing and Focused Ultrasound by CARLISLE, Robert, CHOI, James, BAZAN-PEREGRINO, Miriam, LAGA, Richard, SUBR, Vladimir, KOSTKA, Libor, ULBRICH, Karel, COUSSIOS, Constantin-C, SEYMOUR, Leonard W

“…Oncolytic viruses are among the most powerful and selective cancer therapeutics under development and are showing robust activity in clinical trials,…”
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Cavitation and contrast: the use of bubbles in ultrasound imaging and therapy by Stride, E P, Coussios, C C

“…Microbubbles and cavitation are playing an increasingly significant role in both diagnostic and therapeutic applications of ultrasound. Microbubble ultrasound…”
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Exploitation of acoustic cavitation-induced microstreaming to enhance molecular transport by Bhatnagar, Sunali, Schiffter, Heiko, Coussios, Constantin-C

“…Ultrasound (US) exposure of soft tissues, such as the skin, has been shown to increase permeability, enhancing the passage of drug molecules via passive…”
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Hepatic Steatosis and Normothermic Perfusion-Preliminary Experiments in a Porcine Model by JAMIESON, Russell W, ZILVETTI, Miguel, ROY, Debabrata, HUGHES, David, MOROVAT, Alireza, COUSSIOS, Constantin C, FRIEND, Peter J

“…Steatotic livers are increasingly common in the donor population. Cold storage of steatotic livers exacerbates ischemia-reperfuson injury and risks primary…”
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Spatiotemporal evolution of cavitation dynamics exhibited by flowing microbubbles during ultrasound exposure by Choi, James J, Coussios, Constantin-C

“…Ultrasound and microbubble-based therapies utilize cavitation to generate bioeffects, yet cavitation dynamics during individual pulses and across consecutive…”
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The 24‐hour normothermic machine perfusion of discarded human liver grafts by Vogel, Thomas, Brockmann, Jens G., Quaglia, Alberto, Morovat, Alireza, Jassem, Wayel, Heaton, Nigel D., Coussios, Constantin C., Friend, Peter J.

“…Donor organ shortage necessitates use of less than optimal donor allografts for transplantation. The current cold storage preservation technique fails to…”
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Successful transplantation of porcine liver grafts following 48-hour normothermic preservation by Vogel, Thomas, Brockmann, Jens G, Pigott, David, Neil, Desley A H, Muthusamy, Anand S Rathnasamy, Coussios, Constantin C, Friend, Peter J

“…Current cold storage organ preservation technique fails to preserve marginal donor grafts sufficiently. Evidence from large animal experiments suggests…”
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Microbubbles, Nanodroplets and Gas-Stabilizing Solid Particles for Ultrasound-Mediated Extravasation of Unencapsulated Drugs: An Exposure Parameter Optimization Study by Mannaris, Christophoros, Bau, Luca, Grundy, Megan, Gray, Michael, Lea-Banks, Harriet, Seth, Anjali, Teo, Boon, Carlisle, Robert, Stride, Eleanor, Coussios, Constantin C.

“…Ultrasound-induced cavitation has been proposed as a strategy to tackle the challenge of inadequate extravasation, penetration and distribution of therapeutics…”
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Sum-of-harmonics method for improved narrowband and broadband signal quantification during passive monitoring of ultrasound therapies by Lyka, Erasmia, Coviello, Christian, Kozick, Richard, Coussios, Constantin-C.

“…Passive Acoustic Mapping (PAM) enables real-time monitoring of ultrasound therapies by beamforming acoustic emissions emanating from the ultrasound focus…”
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Ultrasound-Enhanced Thrombolysis Using Definity® as a Cavitation Nucleation Agent by Datta, Saurabh, Coussios, Constantin-C, Ammi, Azzdine Y, Mast, T. Douglas, de Courten-Myers, Gabrielle M, Holland, Christy K

“…Abstract Ultrasound has been shown previously to act synergistically with a thrombolytic agent, such as recombinant tissue plasminogen activator (rt-PA) to…”
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Delivering Focused Ultrasound to Intervertebral Discs Using Time-Reversal by Qiao, S., Elbes, D., Boubriak, O., Urban, J.P.G, Coussios, C-C., Cleveland, R.O.

“…Chronic low back pain causes more disability worldwide than any other condition and is thought to arise in part through loss of biomechanical function of…”
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