Search Results - "Coussens, Lisa M."

Macrophages and Therapeutic Resistance in Cancer by Ruffell, Brian, Coussens, Lisa M.

“…How neoplastic cells respond to therapy is not solely dependent on the complexity of the genomic aberrations they harbor but is also regulated by numerous…”
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Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment by Hanahan, Douglas, Coussens, Lisa M.

“…Mutationally corrupted cancer (stem) cells are the driving force of tumor development and progression. Yet, these transformed cells cannot do it alone…”
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Macrophages and Metabolism in the Tumor Microenvironment by Vitale, Ilio, Manic, Gwenola, Coussens, Lisa M., Kroemer, Guido, Galluzzi, Lorenzo

“…Tumor-associated macrophages (TAMs) constitute a plastic and heterogeneous cell population of the tumor microenvironment (TME) that can account for up to 50%…”
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The Basis of Oncoimmunology by Palucka, A. Karolina, Coussens, Lisa M.

“…Cancer heterogeneity, a hallmark enabling clonal survival and therapy resistance, is shaped by active immune responses. Antigen-specific T cells can control…”
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Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet? by Coussens, Lisa M., Zitvogel, Laurence, Palucka, A. Karolina

“…There have been substantial advances in cancer diagnostics and therapies in the past decade. Besides chemotherapeutic agents and radiation therapy, approaches…”
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Differential macrophage programming in the tumor microenvironment by Ruffell, Brian, Affara, Nesrine I, Coussens, Lisa M

“…Of the multiple unique stromal cell types common to solid tumors, tumor-associated macrophages (TAMs) are significant for fostering tumor progression. The…”
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Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells by Ruffell, Brian, Chang-Strachan, Debbie, Chan, Vivien, Rosenbusch, Alexander, Ho, Christine M.T., Pryer, Nancy, Daniel, Dylan, Hwang, E. Shelley, Rugo, Hope S., Coussens, Lisa M.

“…Blockade of colony-stimulating factor-1 (CSF-1) limits macrophage infiltration and improves response of mammary carcinomas to chemotherapy. Herein we identify…”
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Understanding the tumor immune microenvironment (TIME) for effective therapy by Binnewies, Mikhail, Roberts, Edward W., Kersten, Kelly, Chan, Vincent, Fearon, Douglas F., Merad, Miriam, Coussens, Lisa M., Gabrilovich, Dmitry I., Ostrand-Rosenberg, Suzanne, Hedrick, Catherine C., Vonderheide, Robert H., Pittet, Mikael J., Jain, Rakesh K., Zou, Weiping, Howcroft, T. Kevin, Woodhouse, Elisa C., Weinberg, Robert A., Krummel, Matthew F.

“…The clinical successes in immunotherapy have been both astounding and at the same time unsatisfactory. Countless patients with varied tumor types have seen…”
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Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets by Cassetta, Luca, Fragkogianni, Stamatina, Sims, Andrew H., Swierczak, Agnieszka, Forrester, Lesley M., Zhang, Hui, Soong, Daniel Y.H., Cotechini, Tiziana, Anur, Pavana, Lin, Elaine Y., Fidanza, Antonella, Lopez-Yrigoyen, Martha, Millar, Michael R., Urman, Alexandra, Ai, Zhichao, Spellman, Paul T., Hwang, E. Shelley, Dixon, J. Michael, Wiechmann, Lisa, Coussens, Lisa M., Smith, Harriet O., Pollard, Jeffrey W.

“…The roles of tumor-associated macrophages (TAMs) and circulating monocytes in human cancer are poorly understood. Here, we show that monocyte subpopulation…”
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Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models by Keklikoglou, Ioanna, Cianciaruso, Chiara, Güç, Esra, Squadrito, Mario Leonardo, Spring, Laura M., Tazzyman, Simon, Lambein, Lore, Poissonnier, Amanda, Ferraro, Gino B., Baer, Caroline, Cassará, Antonino, Guichard, Alan, Iruela-Arispe, M. Luisa, Lewis, Claire E., Coussens, Lisa M., Bardia, Aditya, Jain, Rakesh K., Pollard, Jeffrey W., De Palma, Michele

“…Cytotoxic chemotherapy is an effective treatment for invasive breast cancer. However, experimental studies in mice also suggest that chemotherapy has…”
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Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity by DeNardo, David G., Andreu, Pauline, Coussens, Lisa M.

“…Tumor-associated myeloid cells have been implicated in regulating many of the “hallmarks of cancer” and thus fostering solid tumor development and metastasis…”
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Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy by Li, Jinyang, Byrne, Katelyn T., Yan, Fangxue, Yamazoe, Taiji, Chen, Zeyu, Baslan, Timour, Richman, Lee P., Lin, Jeffrey H., Sun, Yu H., Rech, Andrew J., Balli, David, Hay, Ceire A., Sela, Yogev, Merrell, Allyson J., Liudahl, Shannon M., Gordon, Naomi, Norgard, Robert J., Yuan, Salina, Yu, Sixiang, Chao, Timothy, Ye, Shuai, Eisinger-Mathason, T.S. Karin, Faryabi, Robert B., Tobias, John W., Lowe, Scott W., Coussens, Lisa M., Wherry, E. John, Vonderheide, Robert H., Stanger, Ben Z.

“…The biological and functional heterogeneity between tumors—both across and within cancer types—poses a challenge for immunotherapy. To understand the factors…”
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Immune microenvironments in solid tumors: new targets for therapy by Shiao, Stephen L, Ganesan, A Preethi, Rugo, Hope S, Coussens, Lisa M

“…Leukocytes and their soluble mediators play important regulatory roles in all aspects of solid tumor development. While immunotherapeutic strategies have…”
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Tumor stroma and regulation of cancer development by Tlsty, Thea D, Coussens, Lisa M

“…Abstract In the past 25 years, a majority of cancer studies have focused on examining functional consequences of activating and/or inactivating mutations in…”
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Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer by Gunderson, Andrew J, Kaneda, Megan M, Tsujikawa, Takahiro, Nguyen, Abraham V, Affara, Nesrine I, Ruffell, Brian, Gorjestani, Sara, Liudahl, Shannon M, Truitt, Morgan, Olson, Peter, Kim, Grace, Hanahan, Douglas, Tempero, Margaret A, Sheppard, Brett, Irving, Bryan, Chang, Betty Y, Varner, Judith A, Coussens, Lisa M

“…Pancreas ductal adenocarcinoma (PDAC) has one of the worst 5-year survival rates of all solid tumors, and thus new treatment strategies are urgently needed…”
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Leukocyte composition of human breast cancer by Ruffell, Brian, Au, Alfred, Rugo, Hope S, Esserman, Laura J, Hwang, E. Shelley, Coussens, Lisa M

“…Retrospective clinical studies have used immune-based biomarkers, alone or in combination, to predict survival outcomes for women with breast cancer (BC);…”
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The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer by Michaelis, Katherine A., Norgard, Mason A., Zhu, Xinxia, Levasseur, Peter R., Sivagnanam, Shamilene, Liudahl, Shannon M., Burfeind, Kevin G., Olson, Brennan, Pelz, Katherine R., Angeles Ramos, Diana M., Maurer, H. Carlo, Olive, Kenneth P., Coussens, Lisa M., Morgan, Terry K., Marks, Daniel L.

“…A priority in cancer research is to innovate therapies that are not only effective against tumor progression but also address comorbidities such as cachexia…”
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Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis by Tsujikawa, Takahiro, Kumar, Sushil, Borkar, Rohan N., Azimi, Vahid, Thibault, Guillaume, Chang, Young Hwan, Balter, Ariel, Kawashima, Rie, Choe, Gina, Sauer, David, El Rassi, Edward, Clayburgh, Daniel R., Kulesz-Martin, Molly F., Lutz, Eric R., Zheng, Lei, Jaffee, Elizabeth M., Leyshock, Patrick, Margolin, Adam A., Mori, Motomi, Gray, Joe W., Flint, Paul W., Coussens, Lisa M.

“…Here, we describe a multiplexed immunohistochemical platform with computational image processing workflows, including image cytometry, enabling simultaneous…”
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B Cells Regulate Macrophage Phenotype and Response to Chemotherapy in Squamous Carcinomas by Affara, Nesrine I., Ruffell, Brian, Medler, Terry R., Gunderson, Andrew J., Johansson, Magnus, Bornstein, Sophia, Bergsland, Emily, Steinhoff, Martin, Li, Yijin, Gong, Qian, Ma, Yan, Wiesen, Jane F., Wong, Melissa H., Kulesz-Martin, Molly, Irving, Bryan, Coussens, Lisa M.

“…B cells foster squamous cell carcinoma (SCC) development through deposition of immunoglobulin-containing immune complexes in premalignant tissue and Fcγ…”
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The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin by Kenny, Hilary A, Kaur, Swayamjot, Coussens, Lisa M, Lengyel, Ernst

“…Most patients (80%) with ovarian cancer (OvCa) present with metastatic disease. Attachment of OvCa cells to peritoneum and omentum represents the first…”
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