Search Results - "Courtoy, P.‐J."

Dietary supplementation of cystinotic mice by lysine inhibits the megalin pathway and decreases kidney cystine content by Rega, L. R., Janssens, V., Graversen, J. H., Moestrup, S. K., Cairoli, S., Goffredo, B. M., Nevo, N., Courtoy, G. E., Jouret, F., Antignac, C., Emma, F., Pierreux, C. E., Courtoy, P. J.

“…Megalin/LRP2 is a major receptor supporting apical endocytosis in kidney proximal tubular cells. We have previously reported that kidney-specific perinatal…”
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Hematopoietic Stem Cells Transplantation Can Normalize Thyroid Function in a Cystinosis Mouse Model by Gaide Chevronnay, H. P, Janssens, V, Van Der Smissen, P, Rocca, C. J, Liao, X. H, Refetoff, S, Pierreux, C. E, Cherqui, S, Courtoy, P. J

“…Hypothyroidism is the most frequent and earliest endocrine complication in cystinosis, a multisystemic lysosomal storage disease caused by defective…”
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A Mouse Model Suggests Two Mechanisms for Thyroid Alterations in Infantile Cystinosis: Decreased Thyroglobulin Synthesis Due to Endoplasmic Reticulum Stress/Unfolded Protein Response and Impaired Lysosomal Processing by Gaide Chevronnay, H. P, Janssens, V, Van Der Smissen, P, Liao, X. H, Abid, Y, Nevo, N, Antignac, C, Refetoff, S, Cherqui, S, Pierreux, C. E, Courtoy, P. J

“…Thyroid hormones are released from thyroglobulin (Tg) in lysosomes, which are impaired in infantile/nephropathic cystinosis. Cystinosis is a lysosomal cystine…”
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A novel renal carbonic anhydrase type III plays a role in proximal tubule dysfunction by Gailly, P., Jouret, F., Martin, D., Debaix, H., Parreira, K.S., Nishita, T., Blanchard, A., Antignac, C., Willnow, T.E., Courtoy, P.J., Scheinman, S.J., Christensen, E.I., Devuyst, O.

“…Dysfunction of the proximal tubule (PT) is associated with variable degrees of solute wasting and low-molecular-weight proteinuria. We measured metabolic…”
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Binding of matrilysin-1 to human epithelial cells promotes its activity by Berton, A, Selvais, C, Lemoine, P, Henriet, P, Courtoy, P. J, Marbaix, E, Emonard, H

“…Matrix metalloproteinase-7 (MMP-7, matrilysin- 1) modulates crucial biological events by processing many epithelial cell surface-associated effectors. We…”
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Constitutive macropinocytosis in oncogene-transformed fibroblasts depends on sequential permanent activation of phosphoinositide 3-kinase and phospholipase C by Amyere, M, Payrastre, B, Krause, U, Van Der Smissen, P, Veithen, A, Courtoy, P J

“…Macropinocytosis results from the closure of lamellipodia generated by membrane ruffling, thereby reflecting cortical actin dynamics. Both transformation of…”
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Acute ligand-independent Src activation mimics low EGF-induced EGFR surface signalling and redistribution into recycling endosomes by de Diesbach, Medts T., Cominelli, A., N'Kuli, F., Tyteca, D., Courtoy, P.J.

“…Src, a non-receptor tyrosine kinase, is a key signal transduction partner of epidermal growth factor (EGF) receptor (EGFR). In human breast cancer, EGFR and…”
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Intra-Renal and Subcellular Distribution of the Human Chloride Channel, CLC-5, Reveals a Pathophysiological Basis for Dent's Disease by Devuyst, Olivier, Christie, Paul T., Courtoy, Pierre J., Beauwens, Renaud, Thakker, Rajesh V.

“…Dent's disease, which is a renal tubular disorder characterized by low molecular weight proteinuria, hypercalciuria and nephrolithiasis, is associated with…”
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THE ADAPTATIVE MECHANISMS OF TRYPANOSOMA BRUCEI FOR STEROL HOMEOSTASIS IN ITS DIFFERENT LIFE-CYCLE ENVIRONMENTS by Coppens, I, Courtoy, P. J

“…Bloodstream forms of Trypanosoma brucei do not synthesize sterols de novo and therefore cannot survive in medium devoid of lipoproteins. Growth of parasites is…”
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Progesterone Regulates the Activity of Collagenase and Related Gelatinases A and B in Human Endometrial Explants by Marbaix, E., Donnez, J., Courtoy, P. J., Eeckhout, Y.

“…Explants of human endometrium were cultured to study the release of matrix metalloproteinases (MMPs). Analysis of conditioned media by zymography revealed…”
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Focal cellular origin and regulation of interstitial collagenase (matrix metalloproteinase-1) are related to menstrual breakdown in the human endometrium by Kokorine, I, Marbaix, E, Henriet, P, Okada, Y, Donnez, J, Eeckhout, Y, Courtoy, P J

“…Recent studies suggest that interstitial collagenase (MMP-1) is an essential enzyme in the early events leading to menstruation. This study analyses its…”
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The macrolide antibiotic azithromycin interacts with lipids and affects membrane organization and fluidity: studies on Langmuir-Blodgett monolayers, liposomes and J774 macrophages by Tyteca, D, Schanck, A, Dufrêne, Y F, Deleu, M, Courtoy, P J, Tulkens, P M, Mingeot-Leclercq, M P

“…The macrolide antibiotic azithromycin was shown to markedly inhibit endocytosis. Here we investigate the interaction of azithromycin with biomembranes and its…”
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Circulating sex hormones and endometrial stromelysin-1 (matrix metalloproteinase-3) at the start of bleeding episodes in levonorgestrel-implant users by Marbaix, E., Vekemans, M., Galant, C., Rigot, V., Lemoine, P., Dubois, D., Picquet, C., Henriet, P., Twagirayezu, P., Sufi, S., Eeckhout, Y., Courtoy, P.J.

“…Unpredictable endometrial bleeding is the major side-effect of levonorgestrel-releasing s.c. implants (Norplant®), otherwise a method of choice for long-term…”
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Expression of interstitial collagenase (matrix metalloproteinase-1) is related to the activity of human endometriotic lesions by Kokorine, I, Nisolle, M, Donnez, J, Eeckhout, Y, Courtoy, P J, Marbaix, E

“…To determine whether interstitial collagenase (matrix metalloproteinase-1), known to play a pivotal role in the initiation of menstruation, contributes to the…”
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Cell-Mediated Extracellular Acidification and Bone Resorption: Evidence for a Low pH in Resorbing Lacunae and Localization of a 100-kD Lysosomal Membrane Protein at the Osteoclast Ruffled Border by Baron, Roland, Neff, Lynn, Louvard, Daniel, Courtoy, Pierre J.

“…The extracellular compartment where bone resorption occurs, between the osteoclast and bone matrix, is shown in this report to be actively acidified. The weak…”
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Menstrual Breakdown of Human Endometrium can be Mimicked in vitro and is Selectively and Reversibly Blocked by Inhibitors of Matrix Metalloproteinases by Marbaix, Etienne, Kokorine, Isabelle, Moulin, Pierre, Donnez, Jacques, Eeckhout, Yves, Courtoy, Pierre J.

“…The mechanisms underlying the menstrual lysis leading to shedding of the human endometrium and its accompanying bleeding are still largely unknown. In…”
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Polymeric IgA Binding to the Human pIgR Elicits Intracellular Signalling, but Fails to Stimulate pIgR‐Transcytosis by Giffroy, D., Courtoy, P.‐J., Vaerman, J.‐P.

“…The intracellular pathway of polymeric immunoglobulin receptor (pIgR) is governed by multiple signals that lead to constitutive transcytosis. In addition, in…”
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The expression of interstitial collagenase in human endometrium is controlled by progesterone and by oestradiol and is related to menstruation by Marbaix, E, Kokorine, I, Henriet, P, Donnez, J, Courtoy, P J, Eeckhout, Y

“…Human endometrial tissue, sampled at different periods of the reproductive cycle, expressed interstitial collagenase mRNA, protein and activity only just…”
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Regulation and restricted expression of interstitial collagenase suggest a pivotal role in the initiation of menstruation by Marbaix, E., Kokorine, I., Donnez, J., Eeckhout, Y., Courtoy, P. J.

“…Collagenases are the only mammalian enzymes able to cleave, at neutral pH, the triple helical domain of fibrillar collagens, major constituents of the…”
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Intravital multi‐photon microscopy reveals several levels of heterogeneity in endocytic uptake by mouse renal proximal tubules by Caplanusi, A., Parreira, K.S., Lima, W. Rezende, Marien, B., Van Der Smissen, P., De Diesbach, P., Devuyst, O., Courtoy, P.J.

“…Understanding renal function requires one to integrate the structural complexity of kidney nephrons and the dynamic nature of their cellular processes…”
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