Search Results - "Courtney V. Fletcher"

Persistent HIV-1 replication maintains the tissue reservoir during therapy by Lorenzo-Redondo, Ramon, Fryer, Helen R., Bedford, Trevor, Kim, Eun-Young, Archer, John, Kosakovsky Pond, Sergei L., Chung, Yoon-Seok, Penugonda, Sudhir, Chipman, Jeffrey G., Fletcher, Courtney V., Schacker, Timothy W., Malim, Michael H., Rambaut, Andrew, Haase, Ashley T., McLean, Angela R., Wolinsky, Steven M.

“…Lymphoid tissue is a key reservoir established by HIV-1 during acute infection. It is a site associated with viral production, storage of viral particles in…”
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Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues by Fletcher, Courtney V., Staskus, Kathryn, Wietgrefe, Stephen W., Rothenberger, Meghan, Reilly, Cavan, Chipman, Jeffrey G., Beilman, Greg J., Khoruts, Alexander, Thorkelson, Ann, Schmidt, Thomas E., Anderson, Jodi, Perkey, Katherine, Stevenson, Mario, Perelson, Alan S., Douek, Daniel C., Haase, Ashley T., Schacker, Timothy W.

“…Antiretroviral therapy can reduce HIV-1 to undetectable levels in peripheral blood, but the effectiveness of treatment in suppressing replication in lymphoid…”
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Plasma and intracellular pharmacokinetics of tenofovir in patients switched from tenofovir disoproxil fumarate to tenofovir alafenamide by Podany, Anthony T, Bares, Sara H, Havens, Joshua, Dyavar, Shetty Ravi, O’Neill, Jennifer, Lee, Sarah, Fletcher, Courtney V, Swindells, Susan, Scarsi, Kimberly K

“…OBJECTIVES:The aim of the study was to compare the intraindividual plasma and intracellular peripheral blood mononuclear cell (PBMC) pharmacokinetics of…”
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Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption by Rothenberger, Meghan K., Keele, Brandon F., Wietgrefe, Stephen W., Fletcher, Courtney V., Beilman, Gregory J., Chipman, Jeffrey G., Khoruts, Alexander, Estes, Jacob D., Anderson, Jodi, Callisto, Samuel P., Schmidt, Thomas E., Thorkelson, Ann, Reilly, Cavan, Perkey, Katherine, Reimann, Thomas G., Utay, Netanya S., Makamdop, Krystelle Nganou, Stevenson, Mario, Douek, Daniel C., Haase, Ashley T., Schacker, Timothy W.

“…Significance Antiretroviral therapy (ART) effectively suppresses HIV replication; however, treatment cannot be stopped, because latently infected CD4+ T cells…”
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ACE-2, TMPRSS2, and Neuropilin-1 Receptor Expression on Human Brain Astrocytes and Pericytes and SARS-CoV-2 Infection Kinetics by Malik, Johid Reza, Acharya, Arpan, Avedissian, Sean N, Byrareddy, Siddappa N, Fletcher, Courtney V, Podany, Anthony T, Dyavar, Shetty Ravi

“…Angiotensin Converting Enzyme 2 (ACE-2), Transmembrane Serine Protease 2 (TMPRSS-2) and Neuropilin-1 cellular receptors support the entry of SARS-CoV-2 into…”
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Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19 by Chew, Kara W., Moser, Carlee, Daar, Eric S., Wohl, David A., Li, Jonathan Z., Coombs, Robert W., Ritz, Justin, Giganti, Mark, Javan, Arzhang Cyrus, Li, Yijia, Choudhary, Manish C., Deo, Rinki, Malvestutto, Carlos, Klekotka, Paul, Price, Karen, Nirula, Ajay, Fischer, William, Bala, Veenu, Ribeiro, Ruy M., Perelson, Alan S., Fletcher, Courtney V., Eron, Joseph J., Currier, Judith S., Hughes, Michael D., Smith, Davey M.

“…Anti-SARS-CoV-2 monoclonal antibodies are mainstay COVID-19 therapeutics. Safety, antiviral, and clinical efficacy of bamlanivimab were evaluated in the…”
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Role of toll-like receptor 7/8 pathways in regulation of interferon response and inflammatory mediators during SARS-CoV2 infection and potential therapeutic options by Dyavar, Shetty Ravi, Singh, Rahul, Emani, Rohini, Pawar, Ganesh P., Chaudhari, Vinod D., Podany, Anthony T., Avedissian, Sean N., Fletcher, Courtney V., Salunke, Deepak B.

“…Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) is the causative agent of Corona Virus Disease 2019 (COVID-19). Lower production of type I and III…”
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Pharmacometric Characterization of Efavirenz Developmental Pharmacokinetics and Pharmacogenetics in HIV-Infected Children by Salem, Ahmed Hamed, Fletcher, Courtney V, Brundage, Richard C

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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In-vitro and in-vivo assessment of nirmatrelvir penetration into CSF, central nervous system cells, tissues, and peripheral blood mononuclear cells by Avedissian, Sean N., Malik, Johid R., Podany, Anthony T., Neely, Michael, Rhodes, Nathaniel J., Scarsi, Kimberly K., Scheetz, Marc H., Duryee, Michael J., Modebelu, Ukamaka O., Mykris, Timothy M., Winchester, Lee C., Byrareddy, Siddappa N., Fletcher, Courtney V.

“…Three years after SARS-CoV-2 emerged as a global infectious threat, the virus has become endemic. The neurological complications such as depression, anxiety,…”
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Plasma and Intracellular Population Pharmacokinetic Analysis of Tenofovir in HIV-1-Infected Patients by BAHETI, Gautam, KISER, Jennifer J, HAVENS, Peter L, FLETCHER, Courtney V

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Morphine suppresses peripheral responses and transforms brain myeloid gene expression to favor neuropathogenesis in SIV infection by Fox, Howard S, Niu, Meng, Morsey, Brenda M, Lamberty, Benjamin G, Emanuel, Katy, Periyasamy, Palsamy, Callen, Shannon, Acharya, Arpan, Kubik, Gregory, Eudy, James, Guda, Chittibabu, Dyavar, Shetty Ravi, Fletcher, Courtney V, Byrareddy, Siddappa N, Buch, Shilpa

“…The twin pandemics of opioid abuse and HIV infection can have devastating effects on physiological systems, including on the brain. Our previous work found…”
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Publisher Correction: Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19 by Chew, Kara W., Moser, Carlee, Daar, Eric S., Wohl, David A., Li, Jonathan Z., Coombs, Robert W., Ritz, Justin, Giganti, Mark, Javan, Arzhang Cyrus, Li, Yijia, Choudhary, Manish C., Deo, Rinki, Malvestutto, Carlos, Klekotka, Paul, Price, Karen, Nirula, Ajay, Fischer, William, Bala, Veenu, Ribeiro, Ruy M., Perelson, Alan S., Fletcher, Courtney V., Eron, Joseph J., Currier, Judith S., Hughes, Michael D., Smith, Davey M.

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The simultaneous assay of tenofovir and emtricitabine in plasma using LC/MS/MS and isotopically labeled internal standards by Delahunty, Tom, Bushman, Lane, Robbins, Brian, Fletcher, Courtney V.

“…An LC/MS/MS assay we published for tenofovir (TFV) plasma levels is a useful tool for monitoring the pharmacotherapy of HIV-positive individuals [T. Delahunty,…”
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Transcriptomic approach predicts a major role for transforming growth factor beta type 1 pathway in L‐Dopa‐induced dyskinesia in parkinsonian rats by Dyavar, Shetty Ravi, Potts, Lisa F., Beck, Goichi, Dyavar Shetty, Bhagya Laxmi, Lawson, Benton, Podany, Anthony T., Fletcher, Courtney V., Amara, Rama Rao, Papa, Stella M.

“…Dyskinesia induced by long‐term L‐Dopa (LID) therapy in Parkinson disease is associated with altered striatal function whose molecular bases remain unclear…”
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Ingestible sensor system for measuring, monitoring and enhancing adherence to antiretroviral therapy: An open-label, usual care-controlled, randomised trial by Liu, Honghu, Wang, Yan, Huang, Yilan, Xiong, Di, Shen, Jie, Siqueiros, Lisa, Bala, Veenu, Savage, George M., Guerrero, Mario, Corado, Katya, Rosen, Marc I., Fletcher, Courtney V., Daar, Eric S.

“…Co-encapsulated antiretrovirals (ARVs) with ingestible sensor (IS) has the capacity to monitor adherence in real-time using a sensor patch, a mobile device,…”
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Chemotherapy in pediatric brain tumor and the challenge of the blood–brain barrier by Malik, Johid Reza, Podany, Anthony T., Khan, Parvez, Shaffer, Christopher L., Siddiqui, Jawed A., Baranowska‐Kortylewicz, Janina, Le, Jennifer, Fletcher, Courtney V., Ether, Sadia Afruz, Avedissian, Sean N.

“…Background Pediatric brain tumors (PBT) stand as the leading cause of cancer‐related deaths in children. Chemoradiation protocols have improved survival rates,…”
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Real‐Time and Wireless Assessment of Adherence to Antiretroviral Therapy With Co‐Encapsulated Ingestion Sensor in HIV‐Infected Patients: A Pilot Study by Daar, Eric S., Rosen, Marc I., Wang, Yan, Siqueiros, Lisa, Shen, Jie, Guerrero, Mario, Xiong, Di, Dao, John, Young, Todd, Corado, Katya, Fletcher, Courtney V., Liu, Honghu

“…Adherence with antiretroviral therapy is important for preventing disease progression and HIV transmission. The co‐encapsulated pill sensor system sends a…”
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Diminished Peripheral CD29hi Cytotoxic CD4+ T Cells Are Associated With Deleterious Effects During SIV Infection by Olwenyi, Omalla A, Johnson, Samuel D, Pandey, Kabita, Thurman, Michellie, Acharya, Arpan, Buch, Shilpa J, Fox, Howard S, Podany, Anthony T, Fletcher, Courtney V, Byrareddy, Siddappa N

“…Cytotoxic CD4+ T cells (CD4+ CTLs) limit HIV pathogenesis, as evidenced in elite controllers (a subset of individuals who suppress the virus without the need…”
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Sensitive assay for determining plasma tenofovir concentrations by LC/MS/MS by Delahunty, Tom, Bushman, Lane, Fletcher, Courtney V.

“…An LC/MS/MS assay for the determination of tenofovir (TNF) was developed and validated for use with the EDTA anticoagulated human plasma matrix…”
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Pharmacogenetics of Plasma Efavirenz Exposure after Treatment Discontinuation: An Adult AIDS Clinical Trials Group Study by Ribaudo, Heather J., Haas, David W., Tierney, Camlin, Kim, Richard B., Wilkinson, Grant R., Gulick, Roy M., Clifford, David B., Marzolini, Catia, Fletcher, Courtney V., Tashima, Karen T., Kuritzkes, Daniel R., Acosta, Edward P.

“…Background. Efavirenz has a long plasma half-life and a low genetic barrier to resistance. Simultaneously stopping treatment with all agents in…”
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