Search Results - "Courtney, Nicholas A."

Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin by Courtney, Nicholas A., Bao, Huan, Briguglio, Joseph S., Chapman, Edwin R.

“…Synaptic vesicle (SV) exocytosis is mediated by SNARE proteins. Reconstituted SNAREs are constitutively active, so a major focus has been to identify fusion…”
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Excitatory and Inhibitory Neurons Utilize Different Ca2+ Sensors and Sources to Regulate Spontaneous Release by Courtney, Nicholas A., Briguglio, Joseph S., Bradberry, Mazdak M., Greer, Christina, Chapman, Edwin R.

“…Spontaneous neurotransmitter release (mini) is an important form of Ca2+-dependent synaptic transmission that occurs in the absence of action potentials. A…”
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Dynamics and number of trans-SNARE complexes determine nascent fusion pore properties by Bao, Huan, Das, Debasis, Courtney, Nicholas A., Jiang, Yihao, Briguglio, Joseph S., Lou, Xiaochu, Roston, Daniel, Cui, Qiang, Chanda, Baron, Chapman, Edwin R.

“…Analysis at high temporal and spatial resolution shows that the number and dynamics of SNARE proteins available during exocytosis determines the size and…”
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Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder by Bradberry, Mazdak M., Courtney, Nicholas A., Dominguez, Matthew J., Lofquist, Sydney M., Knox, Andrew T., Sutton, R. Bryan, Chapman, Edwin R.

“…At neuronal synapses, synaptotagmin-1 (syt1) acts as a Ca2+ sensor that synchronizes neurotransmitter release with Ca2+ influx during action potential firing…”
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The timing of dopamine- and noradrenaline-mediated transmission reflects underlying differences in the extent of spillover and pooling by Courtney, Nicholas A, Ford, Christopher P

“…Metabotropic transmission typically occurs through the spillover activation of extrasynaptic receptors. This study examined the mechanisms underlying…”
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Mechanisms of 5‐HT1A receptor‐mediated transmission in dorsal raphe serotonin neurons by Courtney, Nicholas A., Ford, Christopher P.

“…Key points In the dorsal raphe nucleus, it is known that serotonin release activates metabotropic 5‐HT1A autoreceptors located on serotonin neurons that leads…”
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Polybasic Patches in Both C2 Domains of Synaptotagmin-1 Are Required for Evoked Neurotransmitter Release by Wu, Zhenyong, Ma, Lu, Courtney, Nicholas A, Zhu, Jie, Landajuela, Ane, Zhang, Yongli, Chapman, Edwin R, Karatekin, Erdem

“…Synaptotagmin-1 (Syt1) is a vesicular calcium sensor required for synchronous neurotransmitter release, composed of a single-pass transmembrane domain linked…”
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Species differences in somatodendritic dopamine transmission determine D2-autoreceptor-mediated inhibition of ventral tegmental area neuron firing by Courtney, Nicholas A, Mamaligas, Aphroditi A, Ford, Christopher P

“…The somatodendritic release of dopamine within the ventral tegmental area (VTA) and substantia nigra pars compacta activates inhibitory postsynaptic…”
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Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons by Piccart, Elisabeth, Courtney, Nicholas A, Branch, Sarah Y, Ford, Christopher P, Beckstead, Michael J

“…Increased dopaminergic signaling is a hallmark of severe mesencephalic pathologies such as schizophrenia and psychostimulant abuse. Activity of midbrain…”
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Mechanisms of 5‐HT 1A receptor‐mediated transmission in dorsal raphe serotonin neurons by Courtney, Nicholas A., Ford, Christopher P.

“…Key points In the dorsal raphe nucleus, it is known that serotonin release activates metabotropic 5‐HT 1A autoreceptors located on serotonin neurons that leads…”
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Excitatory and Inhibitory Neurons Utilize Different Ca 2+ Sensors and Sources to Regulate Spontaneous Release by Courtney, Nicholas A, Briguglio, Joseph S, Bradberry, Mazdak M, Greer, Christina, Chapman, Edwin R

“…Spontaneous neurotransmitter release (mini) is an important form of Ca -dependent synaptic transmission that occurs in the absence of action potentials. A…”
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Trans-SNARE complex dynamics and number determine nascent fusion pore properties by Bao, Huan, Das, Debasis, Courtney, Nicholas A., Jiang, Yihao, Briguglio, Joseph S., Lou, Xiaochu, Roston, Daniel, Cui, Qiang, Chanda, Baron, Chapman, Edwin R.

“…The fusion pore is the first crucial intermediate formed during exocytosis, yet little is known regarding the mechanisms that determine the size and kinetic…”
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Neurotensin Induces Presynaptic Depression of D sub(2) Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons by Piccart, Elisabeth, Courtney, Nicholas A, Branch, Sarah Y, d, Christopher P, Beckstead, Michael J

“…Increased dopaminergic signaling is a hallmark of severe mesencephalic pathologies such as schizophrenia and psychostimulant abuse. Activity of midbrain…”
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Mechanisms of Autoreceptor-Mediated Inhibition in Central Monoamine Neurons by Courtney, Nicholas A

“…This thesis examined the mechanisms of neurotransmission underlying feedback inhibition mediated by somatodendritic G-protein coupled dopamine D2-autoreceptors…”
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Effect of AQP1 knock out on mouse exercise tolerance by Xu, Lumei, Zhou, Yuehan, Courtney, Nicholas A, Radford, Thomas S, Boron, Walter F

“…The water channel Aquaporin 1 (AQP1) is widely expressed throughout the body. Our lab demonstrated that AQP1 also can act as a CO2 channel when heterologously…”
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