Search Results - "Courtney, Cynthia L."

CD8+ T Cell Response to Gammaherpesvirus Infection Mediates Inflammation and Fibrosis in Interferon Gamma Receptor-Deficient Mice by O'Flaherty, Brigid M, Matar, Caline G, Wakeman, Brian S, Garcia, AnaPatricia, Wilke, Carol A, Courtney, Cynthia L, Moore, Bethany B, Speck, Samuel H

“…Idiopathic pulmonary fibrosis (IPF), one of the most severe interstitial lung diseases, is a progressive fibrotic disorder of unknown etiology. However, there…”
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Closely related influenza viruses induce contrasting respiratory tract immunopathology by Le, Vy L, Courtney, Cynthia L, Steel, John, Compans, Richard W

“…The swine-origin H1N1 virus which emerged in 2009 resulted in the first influenza pandemic of the 21(st) century. Although the majority of infections were…”
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PAS‐positive extracellular deposits within germinal centers of hyperplastic follicles during SIV infection in a rhesus macaque by Hong, Jung Joo, Villinger, Francois, Courtney, Cynthia L

“…Background Lymphoid tissue remodeling is characteristic of chronic simian immunodeficiency virus infection. Methods A rhesus macaque infected with SIVmac239…”
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Thyroid Autoantibodies Are Rare in Nonhuman Great Apes and Hypothyroidism Cannot Be Attributed to Thyroid Autoimmunity by Aliesky, Holly, Courtney, Cynthia L, Rapoport, Basil, McLachlan, Sandra M

“…The great apes include, in addition to Homo, the genera Pongo (orangutans), Gorilla (gorillas), and Pan, the latter comprising two species, P. troglodytes…”
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Cartilage Dysplasia and Tissue Mineralization in the Rat Following Administration of a FGF Receptor Tyrosine Kinase Inhibitor by Brown, Alan P., Courtney, Cynthia L., King, Lena M., Groom, Stephen C., Graziano, Michael J.

“…PD176067 is a reversible and selective inhibitor of fibroblast growth factor receptor tyrosine kinase, and was in preclinical development as an angiogenesis…”
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Cutaneous Lesions in the Rat Following Administration of an Irreversible Inhibitor of erbB Receptors, Including the Epidermal Growth Factor Receptor by Brown, Alan P., Dunstan, Robert W., Courtney, Cynthia L., Criswell, Kay A., Graziano, Michael J.

“…CI-1033 (canertinib) is an irreversible inhibitor of the erbB family of transmembrane tyrosine kinase receptors, including the epidermal growth factor (EGF)…”
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Early lymphoid responses and germinal center formation correlate with lower viral load set points and better prognosis of simian immunodeficiency virus infection by Hong, Jung Joo, Amancha, Praveen K, Rogers, Kenneth A, Courtney, Cynthia L, Havenar-Daughton, Colin, Crotty, Shane, Ansari, Aftab A, Villinger, Francois

“…We have investigated the dynamics of germinal center (GC) formation in lymphoid tissues following acute SIV infection. SIV induces a marked follicular…”
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Clinicopathologic Characteristics, Prevalence, and Risk Factors of Spontaneous Diabetes in Sooty Mangabeys (Cercocebus atys) by Jones, Amelia C, Herndon, James G, Courtney, Cynthia L, Collura, Lynn, Cohen, Joyce K

“…In 2008, clinical observations in our colony of sooty mangabeys (Cercocebus atys) suggested a high frequency of type 2 diabetes. Postmortem studies of diabetic…”
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Behavioral, clinical and pathological effects of multiple daily intraperitoneal injections on female mice by Davis, Jennifer N., Courtney, Cynthia L., Superak, Hillary, Taylor, Douglas K.

“…Pharmacological agents are commonly administered to mice through multiple intraperitoneal (i.p.) injections. The i.p. route of administration is usually…”
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Massive occlusive thrombosis of the pulmonary artery in pigtailed macaques chronically infected with R5‐tropic simian‐human immunodeficiency virus by Courtney, Cynthia L., Ethun, Kelly F., Villinger, Francois, Ruprecht, Ruth M., Byrareddy, Siddappa N.

“…Background Pulmonary arterial hypertension (PAH) has been identified as a serious complication of HIV infection. Methods and Results Here, we report sudden…”
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Osteochondromatosis in a Rhesus Macaque (Macaca mulatta) by Matthews, Kristin A, Strait, Karen, Connor-Stroud, Fawn, Courtney, Cynthia L

“…A 5-y-old, male, rhesus macaque (Macaca mulatta) presented with a prominent mass slightly anteriomedial to the right stifle. On exam, multiple radiopaque…”
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Post-transplant lymphoproliferative disorder associated with immunosuppressive therapy for renal transplantation in rhesus macaques (Macaca mulatta) by Page, Eugenia K., Courtney, Cynthia L., Sharma, Prachi, Cheeseman, Jennifer, Jenkins, Joe B., Strobert, Elizabeth, Knechtle, Stuart J.

“…Human post-transplant lymphoproliferative disorder (PTLD) is an abnormal lymphoid proliferation that arises in 1–12% of transplant recipients as a consequence…”
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Retrograde ejaculation associated spontaneous sperm cystolithiasis in four rhesus macaques (Macaca mulatta) by Gumber, Sanjeev, Courtney, Cynthia L., Strait, Karen R., Sharma, Prachi, Freebersyser, Julie E., Crane, Maria M.

“…Retrograde ejaculation (RE) has been reported in humans and animals but RE with subsequent sperm calculi has rarely been reported. This report documents…”
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Safety and Efficacy of Topical Lime Sulfur in Mice Infested with Myocoptes musculinus by Wood, Jennifer S, Courtney, Cynthia L, Lieber, Karen A, Lee, Vanessa K

“…Current treatment options for murine fur mites have limitations in safety and efficacy. This study evaluated whether topical lime sulfur (LS) is an adjunct or…”
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Toxicity and toxicokinetics of the cyclin-dependent kinase inhibitor AG-024322 in cynomolgus monkeys following intravenous infusion by Brown, Alan P., Courtney, Cynthia L., Criswell, Kay A., Holliman, Christopher L., Evering, Winston, Jessen, Bart A.

“…Purpose Cyclin-dependent kinases (CDKs) play a significant role in the control of cell-cycle progression and exhibit aberrant regulation in various neoplastic…”
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Spontaneous Gastric Carcinomas in Sooty Mangabeys (Cercocebus atys) by Sharma, Prachi, Cohen, Joyce K, Paul, Katherine S, Courtney, Cynthia L, Johnson, Zachary P, Anderson, Daniel C

“…Sooty mangabeys (Cercocebus atys) are native to West Africa and are a natural host of SIV, which is implicated in the origin of HIV2. They have been used in…”
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Development of a mouse model of induced Staphylococcus aureus infective endocarditis by Gibson, G.W, Kreuser, S.C, Riley, J.M, Rosebury-Smith, W.S, Courtney, C.L, Juneau, P.L, Hollembaek, J.M, Zhu, T, Huband, M.D, Brammer, D.W

“…We developed a mouse model of Staphylococcus aureus infective endocarditis to evaluate the efficacy of experimental antibacterial compounds for this disease…”
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Cecal Torsion in Rodents Associated with Chronic Administration of Clinafloxacin by Courtney, Cynthia L.

“…The chronic toxicity of clinafloxacin, a fluoroquinolone antibacterial agent, was evaluated in multiple strains of mice and rats. In 5 separate studies, mice…”
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Granular basal cell tumor in a Wistar rat by Courtney, C L, Hawkins, K L, Graziano, M J

“…A granular cell variant of a cutaneous basal cell tumor in a Wistar rat is described. The tumor resembles the variant as described in man and dogs. The…”
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Nasal toxicity of CI-959, a novel anti-inflammatory drug, in Wistar rats and Beagle dogs by Walsh, K M, Courtney, C L

“…CI-959, 5-methoxy-3-(1-methylethoxy)-N-1H-tetrazol-5-yl-benzo[b]thio phene-2-carboxamide, an anti-inflammatory agent, was considered for development as a…”
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