Search Results - "Courtney, Adam H"

TCR Signaling: Mechanisms of Initiation and Propagation by Courtney, Adam H., Lo, Wan-Lin, Weiss, Arthur

“…The mechanisms by which a T cell detects antigen using its T cell antigen receptor (TCR) are crucial to our understanding of immunity and the harnessing of T…”
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Sialylated multivalent antigens engage CD22 in trans and inhibit B cell activation by Courtney, Adam H, Puffer, Erik B, Pontrello, Jason K, Yang, Zhi-Qiang, Kiessling, Laura L

“…CD22 is an inhibitory coreceptor on the surface of B cells that attenuates B cell antigen receptor (BCR) signaling and, therefore, B cell activation…”
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Spatial control of cell fate using synthetic surfaces to potentiate TGF-β signaling by Li, Lingyin, Klim, Joseph R., Derda, Ratmir, Courtney, Adam H., Kiessling, Laura L.

“…In organisms, cell-fate decisions result from external cues presented by the extracellular microenvironment or the niche. In principle, synthetic niches can be…”
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Small molecule inhibition of Csk alters affinity recognition by T cells by Manz, Boryana N, Tan, Ying Xim, Courtney, Adam H, Rutaganira, Florentine, Palmer, Ed, Shokat, Kevan M, Weiss, Arthur

“…The C-terminal Src kinase (Csk), the primary negative regulator of Src-family kinases (SFK), plays a crucial role in controlling basal and inducible receptor…”
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CD45 functions as a signaling gatekeeper in T cells by Courtney, Adam H, Shvets, Alexey A, Lu, Wen, Griffante, Gloria, Mollenauer, Marianne, Horkova, Veronika, Lo, Wan-Lin, Yu, Steven, Stepanek, Ondrej, Chakraborty, Arup K, Weiss, Arthur

“…T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the…”
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Screening and Characterization of Allosteric Small Molecules Targeting Bruton’s Tyrosine Kinase by Kueffer, Lauren E., Lin, David Yin-wei, Amatya, Neha, Serrenho, Joseph, Joseph, Raji E., Courtney, Adam H., Andreotti, Amy H.

“…Bruton’s Tyrosine Kinase (BTK) is a nonreceptor tyrosine kinase that belongs to the TEC family. Mutations in the BTK gene cause X-linked agammaglobulinemia…”
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A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45 by Courtney, Adam H., Amacher, Jeanine F., Kadlecek, Theresa A., Mollenauer, Marianne N., Au-Yeung, Byron B., Kuriyan, John, Weiss, Arthur

“…The Src Family kinase Lck sets a critical threshold for T cell activation because it phosphorylates the TCR complex and the Zap70 kinase. How a T cell controls…”
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Combined analysis of T cell activation and T cell-mediated cytotoxicity by imaging cytometry by Chanda, Monica K., Shudde, Claire E., Piper, Taylor L., Zheng, Yating, Courtney, Adam H.

“…Immunotherapies for the treatment of cancer have spurred the development of new drugs that seek to harness the ability of T cells to recognize and kill…”
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Multivalent Antigens for Promoting B and T Cell Activation by Bennett, Nitasha R, Zwick, Daniel B, Courtney, Adam H, Kiessling, Laura L

“…Efficacious vaccines require antigens that elicit productive immune system activation. Antigens that afford robust antibody production activate both B and T…”
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Synthetic Antigens Reveal Dynamics of BCR Endocytosis during Inhibitory Signaling by Courtney, Adam H, Bennett, Nitasha R, Zwick, Daniel B, Hudon, Jonathan, Kiessling, Laura L

“…B cells detect foreign antigens through their B cell antigen receptor (BCR). The BCR, when engaged by antigen, initiates a signaling cascade. Concurrent with…”
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Small-Molecule-Modified Surfaces Engage Cells through the αvβ3 Integrin by Klim, Joseph R, Fowler, Anthony J, Courtney, Adam H, Wrighton, Paul J, Sheridan, Rachael T. C, Wong, Margaret L, Kiessling, Laura L

“…Integrins play myriad and vital roles in development and disease. They connect a cell with its surroundings and transmit chemical and mechanical signals across…”
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Enhanced cytotoxic CD8+ T cell (CTL) antigen recognition by LCK activation by Zheng, Yating, Piper, Taylor L., Courtney, Adam H.

“…The anti-tumor response of cytotoxic T cells requires detection of tumor-derived antigenic peptide-MHC complex (pMHC) by the T cell antigen receptor (TCR)…”
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A STAT5 activator protects CD8+ T cells in immunosuppressive environments by Shudde, Claire E, Gu, Zehui, Piper, Taylor L, Zheng, Yating, Courtney, Adam H

“…CD8+ T cells are central mediators of an anti-tumor immune response because they can recognize and kill cancerous cells. However, cancer can evade this attack…”
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Uncovering the role of STAT5 in CD8+ T cell fate by Chanda, Monica Kasturi, Gu, Zehui, Piper, Taylor L, Shudde, Claire E, Courtney, Adam H

“…Long-term protection against infection and disease requires long-lived memory CD8+ T cells. The development of these memory CD8+ T cells requires a…”
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Combined analysis of T cell activation and T cell-mediated cytotoxicity by imaging cytometry by Chanda, Monica Kasturi, Shudde, Claire E, Piper, Taylor L, Zheng, Yating, Courtney, Adam H

“…Immunotherapies have transformed the treatment of cancer through the development of drugs that allow T cells to recognize and kill malignant cells. With this…”
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Spatial control of cell fate using synthetic surfaces to potentiate TGF-[Beta] signaling by Li, Lingyin, Klim, Joseph R, Derda, Ratmir, Courtney, Adam H, Kiessling, Laura L

“…In organisms, cell-fate decisions result from external cues presented by the extracellular microenvironment or the niche. In principle, synthetic niches can be…”
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Small-Molecule-Modified Surfaces Engage Cells through the α v β 3 Integrin by Klim, Joseph R., Fowler, Anthony J., Courtney, Adam H., Wrighton, Paul J., Sheridan, Rachael T. C., Wong, Margaret L., Kiessling, Laura L.

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Spatial control of cell fate using synthetic surfaces to potentiate TGF-β signaling by Li, Lingyin, Klim, Joseph R, Derda, Ratmir, Courtney, Adam H, Kiessling, Laura L

“…In organisms, cell-fate decisions result from external cues presented by the extracellular microenvironment or the niche. In principle, synthetic niches can be…”
Get full text