Search Results - "Courtney, Adam"

TCR Signaling: Mechanisms of Initiation and Propagation by Courtney, Adam H., Lo, Wan-Lin, Weiss, Arthur

“…The mechanisms by which a T cell detects antigen using its T cell antigen receptor (TCR) are crucial to our understanding of immunity and the harnessing of T…”
Get full text

CD45 functions as a signaling gatekeeper in T cells by Courtney, Adam H, Shvets, Alexey A, Lu, Wen, Griffante, Gloria, Mollenauer, Marianne, Horkova, Veronika, Lo, Wan-Lin, Yu, Steven, Stepanek, Ondrej, Chakraborty, Arup K, Weiss, Arthur

“…T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the…”
Get more information

Screening and Characterization of Allosteric Small Molecules Targeting Bruton’s Tyrosine Kinase by Kueffer, Lauren E., Lin, David Yin-wei, Amatya, Neha, Serrenho, Joseph, Joseph, Raji E., Courtney, Adam H., Andreotti, Amy H.

“…Bruton’s Tyrosine Kinase (BTK) is a nonreceptor tyrosine kinase that belongs to the TEC family. Mutations in the BTK gene cause X-linked agammaglobulinemia…”
Get full text

A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45 by Courtney, Adam H., Amacher, Jeanine F., Kadlecek, Theresa A., Mollenauer, Marianne N., Au-Yeung, Byron B., Kuriyan, John, Weiss, Arthur

“…The Src Family kinase Lck sets a critical threshold for T cell activation because it phosphorylates the TCR complex and the Zap70 kinase. How a T cell controls…”
Get full text

Combined analysis of T cell activation and T cell-mediated cytotoxicity by imaging cytometry by Chanda, Monica K., Shudde, Claire E., Piper, Taylor L., Zheng, Yating, Courtney, Adam H.

“…Immunotherapies for the treatment of cancer have spurred the development of new drugs that seek to harness the ability of T cells to recognize and kill…”
Get full text

Multivalent Antigens for Promoting B and T Cell Activation by Bennett, Nitasha R, Zwick, Daniel B, Courtney, Adam H, Kiessling, Laura L

“…Efficacious vaccines require antigens that elicit productive immune system activation. Antigens that afford robust antibody production activate both B and T…”
Get full text

Sialylated multivalent antigens engage CD22 in trans and inhibit B cell activation by Courtney, Adam H, Puffer, Erik B, Pontrello, Jason K, Yang, Zhi-Qiang, Kiessling, Laura L

“…CD22 is an inhibitory coreceptor on the surface of B cells that attenuates B cell antigen receptor (BCR) signaling and, therefore, B cell activation…”
Get full text

Spatial control of cell fate using synthetic surfaces to potentiate TGF-β signaling by Li, Lingyin, Klim, Joseph R., Derda, Ratmir, Courtney, Adam H., Kiessling, Laura L.

“…In organisms, cell-fate decisions result from external cues presented by the extracellular microenvironment or the niche. In principle, synthetic niches can be…”
Get full text

Small molecule inhibition of Csk alters affinity recognition by T cells by Manz, Boryana N, Tan, Ying Xim, Courtney, Adam H, Rutaganira, Florentine, Palmer, Ed, Shokat, Kevan M, Weiss, Arthur

“…The C-terminal Src kinase (Csk), the primary negative regulator of Src-family kinases (SFK), plays a crucial role in controlling basal and inducible receptor…”
Get full text

Synthetic Antigens Reveal Dynamics of BCR Endocytosis during Inhibitory Signaling by Courtney, Adam H, Bennett, Nitasha R, Zwick, Daniel B, Hudon, Jonathan, Kiessling, Laura L

“…B cells detect foreign antigens through their B cell antigen receptor (BCR). The BCR, when engaged by antigen, initiates a signaling cascade. Concurrent with…”
Get full text

Small-Molecule-Modified Surfaces Engage Cells through the αvβ3 Integrin by Klim, Joseph R, Fowler, Anthony J, Courtney, Adam H, Wrighton, Paul J, Sheridan, Rachael T. C, Wong, Margaret L, Kiessling, Laura L

“…Integrins play myriad and vital roles in development and disease. They connect a cell with its surroundings and transmit chemical and mechanical signals across…”
Get full text

Enhanced cytotoxic CD8+ T cell (CTL) antigen recognition by LCK activation by Zheng, Yating, Piper, Taylor L., Courtney, Adam H.

“…Abstract The anti-tumor response of cytotoxic T cells requires detection of tumor-derived antigenic peptide-MHC complex (pMHC) by the T cell antigen receptor…”
Get full text

Uncovering the role of STAT5 in CD8+ T cell fate by Chanda, Monica Kasturi, Gu, Zehui, Piper, Taylor L, Shudde, Claire E, Courtney, Adam H

“…Abstract Long-term protection against infection and disease requires long-lived memory CD8+ T cells. The development of these memory CD8+ T cells requires a…”
Get full text

A STAT5 activator protects CD8+ T cells in immunosuppressive environments by Shudde, Claire E, Gu, Zehui, Piper, Taylor L, Zheng, Yating, Courtney, Adam H

“…Abstract CD8+ T cells are central mediators of an anti-tumor immune response because they can recognize and kill cancerous cells. However, cancer can evade…”
Get full text

Combined analysis of T cell activation and T cell-mediated cytotoxicity by imaging cytometry by Chanda, Monica Kasturi, Shudde, Claire E, Piper, Taylor L, Zheng, Yating, Courtney, Adam H

“…Abstract Immunotherapies have transformed the treatment of cancer through the development of drugs that allow T cells to recognize and kill malignant cells…”
Get full text

An engineered viral protein rewires signaling pathways to overcome T cell suppression by Zheng, Yating, Gu, Zehui, Shudde, Claire, Piper, Taylor, Wang, Xinyu, Aleck, Grace, Zhou, Jiajia, Chanda, Monica, Trinch, Lilliana, Zou, Weiping, Courtney, Adam

“…Abstract Cancer can evade destruction by depriving T cells of cytokines, such as IL-2, that cause JAK-STAT signaling required for T cell functionality. We…”
Get full text

Spatial control of cell fate using synthetic surfaces to potentiate TGF-[Beta] signaling by Li, Lingyin, Klim, Joseph R, Derda, Ratmir, Courtney, Adam H, Kiessling, Laura L

“…In organisms, cell-fate decisions result from external cues presented by the extracellular microenvironment or the niche. In principle, synthetic niches can be…”
Get full text

Small-Molecule-Modified Surfaces Engage Cells through the α v β 3 Integrin by Klim, Joseph R., Fowler, Anthony J., Courtney, Adam H., Wrighton, Paul J., Sheridan, Rachael T. C., Wong, Margaret L., Kiessling, Laura L.

Get full text

Spatial control of cell fate using synthetic surfaces to potentiate TGF-β signaling by Li, Lingyin, Klim, Joseph R, Derda, Ratmir, Courtney, Adam H, Kiessling, Laura L

“…In organisms, cell-fate decisions result from external cues presented by the extracellular microenvironment or the niche. In principle, synthetic niches can be…”
Get full text

Wildfire ecology of Big Cypress National Preserve: Process and disturbance in a wetland landscape by Watts, Adam Courtney

“…This dissertation presents a collection of studies that investigate fire’s influence in a spatially patterned landscape, as well as the evidence of processes…”
Get full text