Search Results - "Court, M H"

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for UGT1A1 and Atazanavir Prescribing by Gammal, RS, Court, MH, Haidar, CE, Iwuchukwu, OF, Gaur, AH, Alvarellos, M, Guillemette, C, Lennox, JL, Whirl-Carrillo, M, Brummel, SS, Ratain, MJ, Klein, TE, Schackman, BR, Caudle, KE, Haas, DW

“…The antiretroviral protease inhibitor atazanavir inhibits hepatic uridine diphosphate glucuronosyltransferase (UGT) 1A1, thereby preventing the glucuronidation…”
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Comparative metabolism of mycophenolic acid by glucuronic acid and glucose conjugation in human, dog, and cat liver microsomes by Slovak, J. E., Mealey, K., Court, M. H.

“…Use of the immunosuppressant mycophenolic acid (MPA) in cats is limited because MPA elimination depends on glucuronidation, which is deficient in cats. We…”
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Pomegranate Juice and Pomegranate Extract Do Not Impair Oral Clearance of Flurbiprofen in Human Volunteers: Divergence From In Vitro Results by Hanley, M J, Masse, G, Harmatz, J S, Court, M H, Greenblatt, D J

“…Nutrient interactions with prescription drugs are a topic of ongoing basic and clinical research. Pomegranate juice and a 1‐g capsule containing pomegranate…”
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Role for protein kinase C delta in the functional activity of human UGT1A6: implications for drug-drug interactions between PKC inhibitors and UGT1A6 by Volak, L. P., Court, M. H.

“…Many UDP-glucuronosyltransferases (UGTs) require phosphorylation by protein kinase C (PKC) for glucuronidation activity. Inhibition of UGT phosphorylation by…”
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Preliminary pharmacokinetics and cardiovascular effects of fenoldopam continuous rate infusion in six healthy dogs by BLOOM, C. A, LABATO, M. A, HAZARIKA, S, COURT, M. H

“…Bloom, C. A., Labato, M. A., Hazarika, S., Court, M. H. Preliminary pharmacokinetics and cardiovascular effects of fenoldopam continuous rate infusion in six…”
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CYP2B6 Mediates the In Vitro Hydroxylation of Bupropion: Potential Drug Interactions with Other Antidepressants by HESSE, Leah M, VENKATAKRISHNAN, Karthik, COURT, Michael H, VON MOLTKE, Lisa L, DUAN, S. U. X, SHADER, Richard I, GREENBLATT, David J

“…The in vitro biotransformation of bupropion to hydroxybupropion was studied in human liver microsomes and microsomes containing heterologously expressed human…”
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Acetaminophen UDP-glucuronosyltransferase in ferrets: species and gender differences, and sequence analysis of ferret UGT1A6 by Court, M. H.

“…The principal objective of this study was to determine whether ferrets glucuronidate acetaminophen more slowly compared with other species, and if so…”
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Short-Term Clarithromycin Administration Impairs Clearance and Enhances Pharmacodynamic Effects of Trazodone but Not of Zolpidem by Farkas, D, Volak, LP, Harmatz, JS, Moltke, LL, Court, MH, Greenblatt, DJ

“…The kinetic and dynamic interactions of 5 mg zolpidem and 50 mg trazodone with 500 mg clarithromycin (4 doses given over 32 h) were investigated in a 5‐way…”
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Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms by Court, M H, Duan, S X, von Moltke, L L, Greenblatt, D J, Patten, C J, Miners, J O, Mackenzie, P I

“…Interindividual variability in acetaminophen (APAP) glucuronidation may contribute to differences in susceptibility to APAP intoxication in humans. The purpose…”
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Serotonin (5-hydroxytryptamine) glucuronidation in vitro : assay development, human liver microsome activities and species differences by Krishnaswamy, S., Duan, S. X., Von Moltke, L. L., Greenblatt, D. J., Sudmeier, J. L., Bachovchin, W. W., Court, M. H.

“…1. The main purpose was to develop a high-performance liquid chromatography (HPLC)-based method to assay serotonin glucuronidation activity using liver…”
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Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine : comparison with other selective serotonin reuptake inhibitor antidepressants by VON MOLTKE, L. L, GREENBLATT, D. J, COURT, M. H, SU XIANG DUAN, HARMATZ, J. S, SHADER, R. I

“…In vitro preparations of human liver microsomes were used to study the inhibiting effects of two selective serotonin reuptake inhibitor (SSRI) antidepressants,…”
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Evidence for propofol hydroxylation by cytochrome P4502B11 in canine liver microsomes: breed and gender differences by Hay Kraus, B. L., Greenblatt, D. J., Venkatakrishnan, K., Court, M. H.

“…1. The study aimed to ascertain the enzyme kinetic basis for breed differences in the biotransformation of propofol in dog and to identify the responsible…”
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Pharmacokinetics of Mycophenolic Acid after Intravenous Administration of Mycophenolate Mofetil to Healthy Cats by Slovak, J.E., Rivera, S.M., Hwang, J.K., Court, M.H., Villarino, N.F.

“…Background Mycophenolate mofetil (MMF), the prodrug of mycophenolic acid (MPA), is becoming increasingly popular as an alternative immunosuppressant in feline…”
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Ex vivo binding of the immunosuppressant mycophenolic acid to dog and cat plasma proteins and the effect of co‐incubated dexamethasone and prednisolone by Morassi, A., Rivera-Vélez, S. M., Slovak, J. E., Court, M. H., Villarino, N. F.

“…Mycophenolic acid (MPA) has been shown to be promising for the treatment of autoimmune diseases in dogs and cats. In humans, MPA is highly bound to plasma…”
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Establishment of reference ranges and evaluation of in vitro concentration‐dependent platelet inhibition by acetylsalicylic acid for multiple electrode impedance aggregometry in healthy dogs by Haines, J. M., Lee, P. M., Hegedus, R. M., Hwang, J. K., Court, M. H.

“…Acetylsalicylic acid (ASA, aspirin) is an antiplatelet medication used for prevention of thromboembolism. Effects of ASA appear to vary widely between dogs,…”
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A novel UGT1 marker associated with better tolerance against irinotecan-induced severe neutropenia in metastatic colorectal cancer patients by Chen, S, Laverdiere, I, Tourancheau, A, Jonker, D, Couture, F, Cecchin, E, Villeneuve, L, Harvey, M, Court, M H, Innocenti, F, Toffoli, G, Lévesque, E, Guillemette, C

“…The risk of severe irinotecan-induced neutropenia has been shown to be related to the UGT1 variant UGT1A1*28 , which increases exposure to the potent…”
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pharmacokinetics of intravenous fenoldopam in healthy, awake cats by O'Neill, K. E., Labato, M. A., Court, M. H.

“…Fenoldopam is a selective dopamine‐1 receptor agonist that improves diuresis by increasing renal blood flow and perfusion and causing peripheral vasodilation…”
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Propofol Hydroxylation by Dog Liver Microsomes: Assay Development and Dog Breed Differences by COURT, M. H, HAY-KRAUS, B. L, HILL, D. W, KIND, A. J, GREENBLATT, D. J

“…Pharmacokinetic studies indicate that clearance of propofol, an anesthetic agent, is slower in greyhounds compared with other dog breeds. Biotransformation of…”
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Comparison of chemotherapeutic drug resistance in cells transfected with canine ABCG2 or feline ABCG2 by Lewis, R. S., Fidel, J., Dassanayake, S., Court, M. H., Burke, N. S., Mealey, K. L.

“…ABCG2 (ATP binding cassette subfamily G, member 2) mediates resistance to a variety of cytotoxic agents. Although human ABCG2 is well characterized, the…”
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Identification of polymorphisms in the 3′-untranslated region of the human pregnane X receptor (PXR) gene associated with variability in cytochrome P450 3A (CYP3A) metabolism by Oleson, L., von Moltke, L. L., Greenblatt, D. J., Court, M. H.

“…Single nucleotide polymorphisms in the 3′-untranslated region (3′UTR) of the human pregnane X receptor (PXR) gene might contribute to interindividual…”
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