Search Results - "Couroucli, Xanthi"

Vitamin A deficiency in adolescents: rare or underdiagnosed? by Couroucli, Xanthi I, Dr

“…In The Lancet, Samantha Simkin and colleagues report a case of preventable progressive blindness in an adolescent, caused mainly by vitamin A deficiency…”
Get full text

Analysis of the transcriptome in hyperoxic lung injury and sex-specific alterations in gene expression by Lingappan, Krithika, Srinivasan, Chandra, Jiang, Weiwu, Wang, Lihua, Couroucli, Xanthi I, Moorthy, Bhagavatula

“…Exposure to high concentration of oxygen (hyperoxia) leads to lung injury in experimental animal models and plays a role in the pathogenesis of diseases such…”
Get full text

Mice Lacking the Cytochrome P450 1B1 Gene Are Less Susceptible to Hyperoxic Lung Injury Than Wild Type by Veith, Alex C, Bou Aram, Boura’a, Jiang, Weiwu, Wang, Lihua, Zhou, Guodong, Jefcoate, Colin R, Couroucli, Xanthi I, Lingappan, Krithika, Moorthy, Bhagavatula

“…Abstract Supplemental oxygen is a life-saving intervention administered to individuals suffering from respiratory distress, including adults with acute lung…”
Get full text

Quercetin attenuates the hyperoxic lung injury in neonatal mice: Implications for Bronchopulmonary dysplasia (BPD) by Maturu, Paramahamsa, Wei-Liang, Yanhong, Androutsopoulos, Vasilis P., Jiang, Weiwu, Wang, Lihua, Tsatsakis, Aristides M., Couroucli, Xanthi I.

“…Quercetin (QU) is one of the most common flavonoids that are present in a wide variety of fruits, vegetables, and beverages. This compound possesses potent…”
Get full text

Sex-specific differences in hyperoxic lung injury in mice: Role of cytochrome P450 (CYP)1A by Lingappan, Krithika, Jiang, Weiwu, Wang, Lihua, Couroucli, Xanthi I., Moorthy, Bhagavatula

“…•Cytochrome P450(CYP) 1A shows gender-specific changes in hyperoxic lung injury.•WT female mice show higher CYP1A expression in hyperoxia compared to…”
Get full text

β-Naphthoflavone treatment attenuates neonatal hyperoxic lung injury in wild type and Cyp1a2-knockout mice by Lingappan, Krithika, Maturu, Paramahamsa, Liang, Yanhong Wei, Jiang, Weiwu, Wang, Lihua, Moorthy, Bhagavatula, Couroucli, Xanthi I.

“…Exposure to supraphysiological concentrations of oxygen (hyperoxia) leads to bronchopulmonary dysplasia (BPD), one of the most common pulmonary morbidities in…”
Get full text

Newborn Mice Lacking the Gene for Cyp1a1 Are More Susceptible to Oxygen-Mediated Lung Injury, and Are Rescued by Postnatal β-Naphthoflavone Administration: Implications for Bronchopulmonary Dysplasia in Premature Infants by Maturu, Paramahamsa, Wei-Liang, Yanhong, Jiang, Weiwu, Wang, Lihua, Lingappan, Krithika, Barrios, Roberto, Liang, Yao, Moorthy, Bhagavatula, Couroucli, Xanthi I

“…Prolonged hyperoxia contributes to bronchopulmonary dysplasia (BPD) in preterm infants. β-Naphthoflavone (BNF) is a potent inducer of cytochrome P450 (CYP)1A…”
Get full text

Differential concentration-specific effects of caffeine on cell viability, oxidative stress, and cell cycle in pulmonary oxygen toxicity in vitro by Tiwari, Kirti Kumar, Chu, Chun, Couroucli, Xanthi, Moorthy, Bhagavatula, Lingappan, Krithika

“…•Caffeine at 0.05mM decreases oxidative stress in hyperoxia.•Caffeine at 1mM decreases cell viability, increases oxidative stress in hyperoxia.•Caffeine at 1…”
Get full text

Molecular role of cytochrome P4501A enzymes in oxidative stress by Stading, Rachel, Chu, Chun, Couroucli, Xanthi, Lingappan, Krithika, Moorthy, Bhagavatula

“…Cytochrome P4501A (CYP1A) enzymes play important roles in xenobiotic and endobiotic metabolism. Owing to uncoupling reactions during the enzymatic cycle, CYP1A…”
Get full text

Sex-specific differences in hyperoxic lung injury in mice: Implications for acute and chronic lung disease in humans by Lingappan, Krithika, Jiang, Weiwu, Wang, Lihua, Couroucli, Xanthi I., Barrios, Roberto, Moorthy, Bhagavatula

“…Sex-specific differences in pulmonary morbidity in humans are well documented. Hyperoxia contributes to lung injury in experimental animals and humans. The…”
Get full text

Oxidative stress in the retina: Implications for retinopathy of prematurity by Couroucli, Xanthi I.

“…Oxygen supplementation has been used as a part of respiratory care for preterm and term newborns since the beginning of 19th century. Although oxygen…”
Get full text

Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome by Lingappan, Krithika, Maity, Suman, Jiang, Weiwu, Wang, Lihua, Couroucli, Xanthi, Veith, Alex, Zhou, Guodong, Coarfa, Cristian, Moorthy, Bhagavatula

“…Hyperoxia contributes to lung injury in experimental animals and diseases such as acute respiratory distress syndrome in humans. Cytochrome P450 (CYP)1A…”
Get full text

Omeprazole attenuates hyperoxic lung injury in mice via aryl hydrocarbon receptor activation and is associated with increased expression of cytochrome P4501A enzymes by Shivanna, Binoy, Jiang, Weiwu, Wang, Lihua, Couroucli, Xanthi I, Moorthy, Bhagavatula

“…Hyperoxia contributes to lung injury in experimental animals and bronchopulmonary dysplasia (BPD) in preterm infants. Cytochrome P4501A (CYP1A) enzymes, which…”
Get more information

Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: evidence for protective role of CYP1A1 against oxidative stress by Lingappan, Krithika, Jiang, Weiwu, Wang, Lihua, Wang, Gangduo, Couroucli, Xanthi I, Shivanna, Binoy, Welty, Stephen E, Barrios, Roberto, Khan, M Firoze, Nebert, Daniel W, Roberts, L Jackson, Moorthy, Bhagavatula

“…Hyperoxia contributes to acute lung injury in diseases such as acute respiratory distress syndrome in adults and bronchopulmonary dysplasia in premature…”
Get full text

Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells: A novel target for prevention of hyperoxic lung injury by Dinu, Daniela, Chu, Chun, Veith, Alex, Lingappan, Krithika, Couroucli, Xanthi, Jefcoate, Colin R., Sheibani, Nader, Moorthy, Bhagavatula

“…Supplemental oxygen, which is routinely administered to preterm infants with pulmonary insufficiency, contributes to bronchopulmonary dysplasia (BPD) in these…”
Get full text

Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice by Shivanna, Binoy, Zhang, Wenyan, Jiang, Weiwu, Welty, Stephen E., Couroucli, Xanthi I., Wang, Lihua, Moorthy, Bhagavatula

“…Hyperoxia contributes to the development of bronchopulmonary dysplasia (BPD) in premature infants. New BPD is characterized as having alveolar simplification…”
Get full text

Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury by Wang, Lihua, Lingappan, Krithika, Jiang, Weiwu, Couroucli, Xanthi I., Welty, Stephen E., Shivanna, Binoy, Barrios, Roberto, Wang, Gangduo, Firoze Khan, M., Gonzalez, Frank J., Jackson Roberts, L., Moorthy, Bhagavatula

“…Hyperoxia contributes to acute lung injury in diseases such as acute respiratory distress syndrome. Cytochrome P450 (CYP) 1A enzymes have been implicated in…”
Get full text

Prenatal administration of the cytochrome P4501A inducer, Β-naphthoflavone (BNF), attenuates hyperoxic lung injury in newborn mice: Implications for bronchopulmonary dysplasia (BPD) in premature infants by Couroucli, Xanthi I., Liang, Yan-hong Wei, Jiang, Weiwu, Wang, Lihua, Barrios, Roberto, Yang, Peiying, Moorthy, Bhagavatula

“…Supplemental oxygen contributes to the development of bronchopulmonary dysplasia (BPD) in premature infants. In this investigation, we tested the hypothesis…”
Get full text

Omeprazole attenuates hyperoxic injury in H441 cells via the aryl hydrocarbon receptor by Shivanna, Binoy, Chu, Chun, Welty, Stephen E., Jiang, Weiwu, Wang, Lihua, Couroucli, Xanthi I., Moorthy, Bhagavatula

“…Hyperoxia contributes to the development of bronchopulmonary dysplasia in premature infants. Earlier we observed that aryl hydrocarbon receptor (AhR)-deficient…”
Get full text

Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse by Zhou, Guo-Dong, Zhu, Huiping, Phillips, Tracie D, Wang, Jianbo, Wang, Shi-Zhou, Wang, Fen, Amendt, Brad A, Couroucli, Xanthi I, Donnelly, Kirby C, Moorthy, Bhagavatula

“…Many carcinogenic polycyclic aromatic hydrocarbons (PAHs) and their metabolites can bind covalently to DNA. Carcinogen-DNA adducts may lead to mutations in…”
Get full text