Development of influenza H7N9 virus like particle (VLP) vaccine: Homologous A/Anhui/1/2013 (H7N9) protection and heterologous A/chicken/Jalisco/CPA1/2012 (H7N3) cross-protection in vaccinated mice challenged with H7N9 virus

Highlights • Recombinant A/Anhui/1/2013 (H7N9) HA, NA and avian M1 form virus like particles. • A(H7N9) VLP form enveloped particles containing HA and NA glycoproteins. • A(H7N9) VLP vaccine induced hemagglutinin inhibition (HAI) titers ≥1:64. • A(H7N9) VLP vaccine 100% protective against wild type...

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Bibliographic Details
Published in:	Vaccine Vol. 31; no. 40; pp. 4305 - 4313
Main Authors:	Smith, Gale E, Flyer, David C, Raghunandan, Ramadevi, Liu, Ye, Wei, Ziping, Wu, Yingyun, Kpamegan, Eloi, Courbron, Denise, Fries, Louis F, Glenn, Gregory M
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Ltd 13-09-2013 Elsevier Elsevier Limited
Subjects:	Allergy and Immunology Animal models Animals antibodies Antibodies, Viral - immunology Applied microbiology Avian flu Baculoviridae Baculoviridae - genetics Baculovirus Biological and medical sciences Cell Line Chickens Cloning Cross Protection - immunology Fundamental and applied biological sciences. Psychology H7N9 Hemagglutination Inhibition Tests Hemagglutinin hemagglutinins Hemagglutinins, Viral - genetics Hemagglutinins, Viral - immunology human diseases immune response Immunogenicity Influenza Influenza A Virus, H7N3 Subtype - immunology Influenza A Virus, H7N9 Subtype - immunology Influenza Vaccines - immunology insects Mice Mice, Inbred BALB C Microbiology Miscellaneous Nanoparticles Neuraminidase - genetics Neuraminidase - immunology nucleotide sequences Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Pandemic Pandemics Proteins sialidase Spodoptera - genetics Spodoptera - metabolism Spodoptera frugiperda Vaccination Vaccine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - immunology Viral Matrix Proteins - genetics Viral Matrix Proteins - immunology virion Virology Virus like particle virus-like particle vaccines viruses China Pandemic Vaccine H7N9 Hemagglutinin Influenza Virus like particle Farming animal Poultry Cross protection Rodentia Orthomyxoviridae Influenzavirus Infection Virus Vertebrata Mammalia Mouse Viral disease Chicken Aves Veterinary Flulike syndrome
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Summary:	Highlights • Recombinant A/Anhui/1/2013 (H7N9) HA, NA and avian M1 form virus like particles. • A(H7N9) VLP form enveloped particles containing HA and NA glycoproteins. • A(H7N9) VLP vaccine induced hemagglutinin inhibition (HAI) titers ≥1:64. • A(H7N9) VLP vaccine 100% protective against wild type A/Anhui/1/2013 (H7N9) influenza challenge. • A(H7N9) VLP vaccine in vivo data support clinical development in man.
Bibliography:	http://dx.doi.org/10.1016/j.vaccine.2013.07.043 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.07.043