Search Results - "Courbet, Alexis"

Design of multi-scale protein complexes by hierarchical building block fusion by Hsia, Yang, Mout, Rubul, Sheffler, William, Edman, Natasha I., Vulovic, Ivan, Park, Young-Jun, Redler, Rachel L., Bick, Matthew J., Bera, Asim K., Courbet, Alexis, Kang, Alex, Brunette, T. J., Nattermann, Una, Tsai, Evelyn, Saleem, Ayesha, Chow, Cameron M., Ekiert, Damian, Bhabha, Gira, Veesler, David, Baker, David

“…A systematic and robust approach to generating complex protein nanomaterials would have broad utility. We develop a hierarchical approach to designing…”
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Reconfigurable asymmetric protein assemblies through implicit negative design by Sahtoe, Danny D, Praetorius, Florian, Courbet, Alexis, Hsia, Yang, Wicky, Basile I M, Edman, Natasha I, Miller, Lauren M, Timmermans, Bart J R, Decarreau, Justin, Morris, Hana M, Kang, Alex, Bera, Asim K, Baker, David

“…Asymmetric multiprotein complexes that undergo subunit exchange play central roles in biology but present a challenge for design because the components must…”
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Computer‐aided biochemical programming of synthetic microreactors as diagnostic devices by Courbet, Alexis, Amar, Patrick, Fages, François, Renard, Eric, Molina, Franck

“…Biological systems have evolved efficient sensing and decision‐making mechanisms to maximize fitness in changing molecular environments. Synthetic biologists…”
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Bringing next‐generation diagnostics to the clinic through synthetic biology by Courbet, Alexis, Renard, Eric, Molina, Franck

“…The promise for real precision medicine is contingent on innovative technological solutions to diagnosis and therapy. In the post‐genomic era, rational and…”
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Imidazoquinoxaline anticancer derivatives and imiquimod interact with tubulin: Characterization of molecular microtubule inhibiting mechanisms in correlation with cytotoxicity by Courbet, Alexis, Bec, Nicole, Constant, Caroline, Larroque, Christian, Pugniere, Martine, El Messaoudi, Safia, Zghaib, Zahraa, Khier, Sonia, Deleuze-Masquefa, Carine, Gattacceca, Florence

“…Displaying a strong antiproliferative activity on a wide variety of cancer cells, EAPB0203 and EAPB0503 belong to the imidazo[1,2-a]quinoxalines family of…”
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Detection of pathological biomarkers in human clinical samples via amplifying genetic switches and logic gates by Courbet, Alexis, Endy, Drew, Renard, Eric, Molina, Franck, Bonnet, Jérôme

“…Whole-cell biosensors have several advantages for the detection of biological substances and have proven to be useful analytical tools. However, several…”
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De novo design of protein structure and function with RFdiffusion by Watson, Joseph L., Juergens, David, Bennett, Nathaniel R., Trippe, Brian L., Yim, Jason, Eisenach, Helen E., Ahern, Woody, Borst, Andrew J., Ragotte, Robert J., Milles, Lukas F., Wicky, Basile I. M., Hanikel, Nikita, Pellock, Samuel J., Courbet, Alexis, Sheffler, William, Wang, Jue, Venkatesh, Preetham, Sappington, Isaac, Torres, Susana Vázquez, Lauko, Anna, De Bortoli, Valentin, Mathieu, Emile, Ovchinnikov, Sergey, Barzilay, Regina, Jaakkola, Tommi S., DiMaio, Frank, Baek, Minkyung, Baker, David

“…There has been considerable recent progress in designing new proteins using deep-learning methods 1 – 9 . Despite this progress, a general deep-learning…”
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Top-down design of protein architectures with reinforcement learning by Lutz, Isaac D, Wang, Shunzhi, Norn, Christoffer, Courbet, Alexis, Borst, Andrew J, Zhao, Yan Ting, Dosey, Annie, Cao, Longxing, Xu, Jinwei, Leaf, Elizabeth M, Treichel, Catherine, Litvicov, Patrisia, Li, Zhe, Goodson, Alexander D, Rivera-Sánchez, Paula, Bratovianu, Ana-Maria, Baek, Minkyung, King, Neil P, Ruohola-Baker, Hannele, Baker, David

“…As a result of evolutionary selection, the subunits of naturally occurring protein assemblies often fit together with substantial shape complementarity to…”
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Accurate computational design of three-dimensional protein crystals by Li, Zhe, Wang, Shunzhi, Nattermann, Una, Bera, Asim K., Borst, Andrew J., Yaman, Muammer Y., Bick, Matthew J., Yang, Erin C., Sheffler, William, Lee, Byeongdu, Seifert, Soenke, Hura, Greg L., Nguyen, Hannah, Kang, Alex, Dalal, Radhika, Lubner, Joshua M., Hsia, Yang, Haddox, Hugh, Courbet, Alexis, Dowling, Quinton, Miranda, Marcos, Favor, Andrew, Etemadi, Ali, Edman, Natasha I., Yang, Wei, Weidle, Connor, Sankaran, Banumathi, Negahdari, Babak, Ross, Michael B., Ginger, David S., Baker, David

“…Protein crystallization plays a central role in structural biology. Despite this, the process of crystallization remains poorly understood and highly…”
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Hallucination of closed repeat proteins containing central pockets by An, Linna, Hicks, Derrick R., Zorine, Dmitri, Dauparas, Justas, Wicky, Basile I. M., Milles, Lukas F., Courbet, Alexis, Bera, Asim K., Nguyen, Hannah, Kang, Alex, Carter, Lauren, Baker, David

“…In pseudocyclic proteins, such as TIM barrels, β barrels, and some helical transmembrane channels, a single subunit is repeated in a cyclic pattern, giving…”
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Generation of ordered protein assemblies using rigid three-body fusion by Vulovic, Ivan, Yao, Qing, Park, Young-Jun, Courbet, Alexis, Norris, Andrew, Busch, Florian, Sahasrabuddhe, Aniruddha, Merten, Hannes, Sahtoe, Danny D., Ueda, George, Fallas, Jorge A., Weaver, Sara J., Hsia, Yang, Langan, Robert A., Plückthun, Andreas, Wysocki, Vicki H., Veesler, David, Jensen, Grant J., Baker, David

“…Protein nanomaterial design is an emerging discipline with applications in medicine and beyond. A long-standing design approach uses genetic fusion to join…”
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Computer‐aided biochemical programming of synthetic microreactors as diagnostic devices by Courbet, Alexis, Amar, Patrick, Fages, François, Renard, Eric, Molina, Franck

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Blueprinting extendable nanomaterials with standardized protein blocks by Huddy, Timothy F., Hsia, Yang, Kibler, Ryan D., Xu, Jinwei, Bethel, Neville, Nagarajan, Deepesh, Redler, Rachel, Leung, Philip J. Y., Weidle, Connor, Courbet, Alexis, Yang, Erin C., Bera, Asim K., Coudray, Nicolas, Calise, S. John, Davila-Hernandez, Fatima A., Han, Hannah L., Carr, Kenneth D., Li, Zhe, McHugh, Ryan, Reggiano, Gabriella, Kang, Alex, Sankaran, Banumathi, Dickinson, Miles S., Coventry, Brian, Brunette, T. J., Liu, Yulai, Dauparas, Justas, Borst, Andrew J., Ekiert, Damian, Kollman, Justin M., Bhabha, Gira, Baker, David

“…A wooden house frame consists of many different lumber pieces, but because of the regularity of these building blocks, the structure can be designed using…”
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Computing with Synthetic Protocells by Courbet, Alexis, Molina, Franck, Amar, Patrick

“…In this article we present a new kind of computing device that uses biochemical reactions networks as building blocks to implement logic gates. The…”
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Erratum To: Computer‐aided biochemical programming of synthetic microreactors as diagnostic devices by Courbet, Alexis, Amar, Patrick, Fages, François, Renard, Eric, Molina, Franck

“…Graphical Abstract…”
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Self-assembly-based posttranslational protein oscillators by Kimchi, Ofer, Goodrich, Carl P, Courbet, Alexis, Curatolo, Agnese I, Woodall, Nicholas B, Baker, David, Brenner, Michael P

“…Recent advances in synthetic posttranslational protein circuits are substantially impacting the landscape of cellular engineering and offer several advantages…”
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Imiqualines: promising anticancer molecules binding colchicine site on tubulin by Gattacceca, Florence, Courbet, Alexis, El Messaoudi, Safia, Khier, Sonia, Constant, Caroline, Bec, Nicole, Larroque, Christian, Pugnière, Martine, Doulain, Pierre‐Emmanuel, Cuq, Pierre, Bonnet, Pierre‐Antoine, Masquefa, Carine

“…Abstract only Our group has developed two innovative synthesis strategies that allowed to produce a 50‐member family of Imidazo[1,2a] quinoxaline compounds,…”
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