Search Results - "Couraud, P. O."

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function by Griep, L. M., Wolbers, F., de Wagenaar, B., ter Braak, P. M., Weksler, B. B., Romero, I. A., Couraud, P. O., Vermes, I., van der Meer, A. D., van den Berg, A.

“…The blood-brain barrier (BBB) is a unique feature of the human body, preserving brain homeostasis and preventing toxic substances to enter the brain. However,…”
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Blood-brain barrier-specific properties of a human adult brain endothelial cell line by Weksler, B. B, Subileau, E. A, Perrière, N, Charneau, P, Holloway, K, Leveque, M, Tricoire-Leignel, H, Nicotra, A, Bourdoulous, S, Turowski, P, Male, D. K, Roux, F, Greenwood, J, Romero, I. A, Couraud, P. O

“…ABSTRACTEstablishment of a human model of the blood‐brain barrier has proven to be a difficult goal. To accomplish this, normal human brain endothelial cells…”
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Puromycin‐based purification of rat brain capillary endothelial cell cultures. Effect on the expression of blood–brain barrier‐specific properties by Perrière, N., Demeuse, PH, Garcia, E., Regina, A., Debray, M., Andreux, J.‐P., Couvreur, P., Scherrmann, J.‐M., Temsamani, J., Couraud, P.‐O., Deli, M. A., Roux, F.

“…One of the main difficulties with primary rat brain endothelial cell (RBEC) cultures is obtaining pure cultures. The variation in purity limits the achievement…”
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Characterizing the pathotype of neonatal meningitis causing Escherichia coli (NMEC) by Wijetunge, D S S, Gongati, S, DebRoy, C, Kim, K S, Couraud, P O, Romero, I A, Weksler, B, Kariyawasam, S

“…Neonatal meningitis-causing Escherichia coli (NMEC) is the predominant Gram-negative bacterial pathogen associated with meningitis in newborn infants. High…”
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Circulating endothelial progenitor cells in systemic sclerosis: association with disease severity by Avouac, J, Juin, F, Wipff, J, Couraud, P O, Chiocchia, G, Kahan, A, Boileau, C, Uzan, G, Allanore, Y

“…Heterogeneous data have been reported regarding the detection and number of circulating endothelial progenitor cells (EPCs) in systemic sclerosis (SSc). We…”
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The association of statins plus LDL receptor‐targeted liposome‐encapsulated doxorubicin increases in vitro drug delivery across blood–brain barrier cells by Pinzón‐Daza, ML, Garzón, R, Couraud, PO, Romero, IA, Weksler, B, Ghigo, D, Bosia, A, Riganti, C

“…BACKGROUND AND PURPOSE The passage of drugs across the blood–brain barrier (BBB) limits the efficacy of chemotherapy in brain tumours. For instance, the…”
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ICAM-1-Coupled Cytoskeletal Rearrangements and Transendothelial Lymphocyte Migration Involve Intracellular Calcium Signaling in Brain Endothelial Cell Lines by Etienne-Manneville, Sandrine, Manneville, Jean-Baptiste, Adamson, Peter, Wilbourn, Barry, Greenwood, John, Couraud, Pierre-Olivier

“…Endothelium of the cerebral blood vessels, which constitutes the blood-brain barrier, controls adhesion and trafficking of leukocytes into the brain…”
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Carrier-Mediated Cocaine Transport at the Blood-Brain Barrier as a Putative Mechanism in Addiction Liability by Chapy, Hélène, Smirnova, Maria, André, Pascal, Schlatter, Joël, Chiadmi, Fouad, Couraud, Pierre-Olivier, Scherrmann, Jean-Michel, Declèves, Xavier, Cisternino, Salvatore

“…Background: The rate of entry of cocaine into the brain is a critical factor that influences neuronal plasticity and the development of cocaine addiction…”
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Mrp1 Multidrug Resistance‐Associated Protein and P‐Glycoprotein Expression in Rat Brain Microvessel Endothelial Cells by Regina, Anthony, Koman, Ahmet, Piciotti, Michèle, El Hafny, Bouchra, Center, Melvin S., Bergmann, Ralf, Couraud, Pierre‐Olivier, Roux, Françoise

“…: Two membrane glycoproteins acting as energy‐dependent efflux pumps, mdr‐encoded P‐glycoprotein (P‐gp) and the more recently described multidrug…”
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Regulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells by Roux, F, Durieu-Trautmann, O, Chaverot, N, Claire, M, Mailly, P, Bourre, J M, Strosberg, A D, Couraud, P O

“…Rat brain microvessel endothelial cells were immortalized by transfection with a plasmid containing the E1A adenovirus gene. One clone, called RBE4, was…”
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Lymphocyte Migration Through Brain Endothelial Cell Monolayers Involves Signaling Through Endothelial ICAM-1 Via a Rho-Dependent Pathway by Adamson, Peter, Etienne, Sandrine, Couraud, Pierre-Olivier, Calder, Virginia, Greenwood, John

“…Lymphocyte extravasation into the brain is mediated largely by the Ig superfamily molecule ICAM-1. Several lines of evidence indicate that at the tight…”
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Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP by Di Benedetto, M., Bièche, I., Deshayes, F., Vacher, S., Nouet, S., Collura, V., Seitz, I., Louis, S., Pineau, P., Amsellem-Ouazana, D., Couraud, P.O., Strosberg, A.D., Stoppa-Lyonnet, D., Lidereau, R., Nahmias, C.

“…The Mitochondrial Tumor suppressor 1 ( MTUS1) gene is a newly identified candidate tumor suppressor gene at chromosomal position 8p22. We report here that…”
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Intercellular adhesion molecule 1 activation induces tyrosine phosphorylation of the cytoskeleton-associated protein cortactin in brain microvessel endothelial cells by DURIEU-TRAUTMANN, O, CHAVEROT, N, CAZAUBON, S, STROSBERG, A. D, COURAUD, P.-O

“…Inflammatory diseases of the central nervous system, such as multiple sclerosis or experimental autoimmune encephalomyelitis, are characterized by adhesion of…”
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ICAM-1 Signaling Pathways Associated with Rho Activation in Microvascular Brain Endothelial Cells by Etienne, Sandrine, Adamson, Peter, Greenwood, John, Strosberg, A. Donny, Cazaubon, Sylvie, Couraud, Pierre-Olivier

“…Endothelium of the cerebral blood vessels, which constitutes the blood-brain barrier, controls leukocyte adhesion and trafficking to the brain. Investigating…”
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Dexamethasone Regulation of P‐Glycoprotein Activity in an Immortalized Rat Brain Endothelial Cell Line, GPNT by REGINA, A, ROMERO, I. A, GREENWOOD, J, ADAMSON, P, BOURRE, J.-M, COURAUD, P.-O, ROUX, F

“…The blood-brain barrier (BBB) plays an important role in controlling the passage of molecules from the blood to the extracellular fluid environment of the…”
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Puromycin selectively increases mdr1a expression in immortalized rat brain endothelial cell lines by Demeuse, P., Fragner, P., Leroy‐Noury, C., Mercier, C., Payen, L., Fardel, O., Couraud, P. ‐O., Roux, F.

“…The blood–brain barrier (BBB) plays an important role in controlling the passage of molecules from blood to brain extracellular fluid. The multidrug efflux…”
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Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/ MTUS1 in hepatocellular carcinoma by Di Benedetto, M., Pineau, P., Nouet, S., Berhouet, S., Seitz, I., Louis, S., Dejean, A., Couraud, P.O., Strosberg, A.D., Stoppa-Lyonnet, D., Nahmias, C.

“…A high frequency of allelic loss affecting chromosome 8p and a minimal region of deletion at p21-22 have been previously reported in hepatocellular carcinoma…”
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Requirement of Caveolae Microdomains in Extracellular Signal‐Regulated Kinase and Focal Adhesion Kinase Activation Induced by Endothelin‐1 in Primary Astrocytes by Teixeira, Alexandra, Chaverot, Nathalie, Schröder, Christian, Strosberg, A. Donny, Couraud, Pierre‐Olivier, Cazaubon, Sylvie

“…: Endothelin‐1 (ET‐1) mitogenic activity in astrocytes is mediated by the activation of the extracellular signal‐regulated kinase (ERK) pathway together with…”
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Hydroxyurea downregulates endothelin-1 gene expression and upregulates ICAM-1 gene expression in cultured human endothelial cells by Brun, M, Bourdoulous, S, Couraud, P O, Elion, J, Krishnamoorthy, R, Lapoumeroulie, C

“…The clinical efficacy of oral hydroxyurea (HU) in adults and children with sickle cell anemia (SCA) cannot solely be explained by its ability to enhance fetal…”
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Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-β variants in cells composing the cerebral vessel walls by Fossati, S, Cam, J, Meyerson, J, Mezhericher, E, Romero, I.A, Couraud, P.O, Weksler, B.B, Ghiso, J, Rostagno, A

“…Cerebral amyloid angiopathy (CAA) is an age-associated condition and a common finding in Alzheimer's disease in which amyloid-β (Aβ) vascular deposits are…”
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