Use of Depot Antipsychotic Medications for Medication Nonadherence in Schizophrenia

Objectives: To describe factors associated with initiation of depot antipsychotic medications in psychiatric outpatients with schizophrenia and recent medication nonadherence. Methods: A national sample of psychiatrists reported on adult outpatients with schizophrenia who were nonadherent with oral...

Full description

Saved in:

Bibliographic Details
Published in:	Schizophrenia bulletin Vol. 34; no. 5; pp. 995 - 1001
Main Authors:	West, Joyce C., Marcus, Steven C., Wilk, Joshua, Countis, Lisa M., Regier, Darrel A., Olfson, Mark
Format:	Journal Article
Language:	English
Published:	Oxford Oxford University Press 01-09-2008 Oxford Publishing Limited (England)
Subjects:	Adolescent Adult Aged Antipsychotic Agents - therapeutic use Biological and medical sciences Female Health staff related problems. Vocational training Humans Injections, Intramuscular Male Medical sciences Middle Aged Neuropharmacology Patient Compliance - statistics & numerical data Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Regular Schizophrenia - drug therapy Schizophrenia - epidemiology Social psychiatry. Ethnopsychiatry United States North America America depot nonadherence antipsychotics Social environment Human Treatment resistance Intravenous administration Health staff Controlled release form Neuroleptic Decision making Psychotropic Mental health Pharmacotherapy Schizophrenia Psychiatrist Psychosis Drug compliance Treatment Medical prescription Dosage form Public health
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Objectives: To describe factors associated with initiation of depot antipsychotic medications in psychiatric outpatients with schizophrenia and recent medication nonadherence. Methods: A national sample of psychiatrists reported on adult outpatients with schizophrenia who were nonadherent with oral antipsychotic medications in the last year. Results: In total, 17.6% of psychiatrists initiated depot antipsychotic injections. Initiation was significantly and positively associated with public insurance, prior inpatient admission, proportion of time nonadherent, average or above average intellectual functioning, and living in a mental health residence. Use was inversely associated with using second-generation antipsychotics and other oral psychotropic medications prior to medication nonadherence. Psychiatrists who were male, nonwhite, and more optimistic about managing nonadherence were more likely to initiate depot injections. Conclusions: Initiation of depot injections is a joint function of patient, physician, treatment, and setting factors. Use of long-acting preparations in this population is uncommon despite clinical recommendations urging their use.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0586-7614 1745-1701
DOI:	10.1093/schbul/sbm137