Search Results - "Coumbarides, Gregory S."

Chemical and bioassay techniques to authenticate quality of the anti-leishmanial drug miltefosine by Kaur, Harparkash, Seifert, Karin, Hawkes, Geoffrey E, Coumbarides, Gregory S, Alvar, Jorge, Croft, Simon L

“…Miltefosine, an effective oral treatment of visceral leishmaniasis (VL), was selected in May 2005, by the governments of India, Nepal, and Bangladesh for the…”
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Enantioselective Protonation of a Lithium Enolate Derived from 2-Methyl-1-tetralone Using Chiral Sulfonamides by Coumbarides, Gregory S, Eames, Jason, Scheuermann, J. Erik W, Sibbons, Kevin F, Suggate, Michael J, Watkinson, Michael

“…The synthesis of enantiomerically enriched (R)-2-methyl-1-tetralone (1) with 77% e.e. was achieved through protonation of its lithium enolate (3) using a…”
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Stereoselective Synthesis of (E)-Mannosylidene Derivatives Using the Wittig Reaction by Coumbarides, Gregory S, Motevalli, Majid, Muse, Warda A, Wyatt, Peter B

“…Stabilized ylides Bu3PCH(EWG), where EWG is an ester or nitrile group, react with 2,3,4,6-tetra-O-benzylmannono-1,5-lactone giving high yields of…”
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Parallel kinetic resolution of an oxazolidinone using a quasi-enantiomeric combination of [D,13C]-isotopomers of pentafluorophenyl 2-phenyl propionate by Coumbarides, Gregory S., Dingjan, Marco, Eames, Jason, Flinn, Anthony, Northen, Julian

“…Parallel kinetic resolution of Evans' phenylglycine derived oxazolidinone using an equimolar combination of quasi‐enantiomeric active esters (derived from…”
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Mutual kinetic separation of isotopomers of pentafluorophenyl 2-phenyl propionate using quasi-enantiomeric oxazolidinones by Chavda, Sameer, Coumbarides, Gregory S., Dingjan, Marco, Eames, Jason, Flinn, Anthony, Northen, Julian

“…Mutual separation of an equimolar mixture of quasi‐enantiomeric [D,13C]‐labeled isotopomers of pentafluorophenyl 2‐phenylpropionate can be achieved efficiently…”
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An efficient laboratory synthesis of α-deuteriated profens by Coumbarides, Gregory S., Dingjan, Marco, Eames, Jason, Flinn, Anthony, Northen, Julian

“…An efficient and practical laboratory synthesis of a series of 2‐deuterio‐2‐arylpropionic acids (α‐deuterioprofens) is described. The levels of deuterium…”
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Investigations into the Regioselective C-Deuteration of Acyclic and Exocyclic Enolates by Eames, Jason, Coumbarides, Gregory S., Suggate, Michael J., Weerasooriya, Neluka

“…Results are reported on the regioselective C‐deuteration of a series of related acyclic and exocyclic enolates derived from substituted aryl ketones. We…”
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Synthesis of enantiomerically pure isotopomers of 2-phenylpropionic acids by Chavda, Sameer, Coumbarides, Gregory S., Dingjan, Marco, Eames, Jason, Flinn, Anthony, Ghilagaber, Stephanos, Northen, Julian, Yohannes, Yonas

“…A series of enantiomerically pure [D,13C]‐labeled isotopomeric 2‐phenylpropionic acids were efficiently synthesized using a diastereoselective alkylation and…”
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Investigations on the Efficiency of Regioselective C-Deuteration of Endocyclic Enolates by Eames, Jason, Weerasooriya, Neluka, Coumbarides, Gregory S.

“…Regioselective C‐deuteration of a series of Endocyclic enolates (derived from cyclic aryl ketones) was efficiently achieved by quenching the corresponding…”
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Investigations into the C-deuteriation of aryl alkyl ketones using urea as a pro-base in the presence of a deuterium donor by Coumbarides, Gregory S., Eames, Jason, Suggate, Michael J., Weerasooriya, Neluka

“…Results are reported on the regioselective C‐deuteriation of a series of enolates derived from the deprotonation of aryl alkyl ketones using dilithiated urea…”
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Investigations into the C-deuteriation of silyl enol ethers derived from aryl alkyl ketones by Buksha, Svitlana, Coumbarides, Gregory S., Dingjan, Marco, Eames, Jason, Suggate, Michael J., Weerasooriya, Neluka

“…Results are reported on the regioselective C‐deuteriation of a series of silyl enol ethers derived from aryl alkyl ketones using deuterium (D2) gas as the…”
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Investigations into the mechanism of regioselective C-deuteriation of enolates under ‘base-free’ conditions by Coumbarides, Gregory S, Eames, Jason, Weerasooriya, Neluka

“…Regioselective C-deuteriation of enolates was efficiently achieved by quenching the corresponding base-free enolate in the presence of a carbonyl chelating…”
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Probing the regioselective C-deuteriation of lithium enolates derived from 2-methyl-tetralone in the presence of substituted tertiary amines by Begum, Mothia, Chavda, Sameer, Coumbarides, Gregory S., Dingan, Marco, Eames, Jason, Suggate, Michael J., Weerasooriya, Neluka

“…Results are reported on the regioselective C‐deuteriation of 2‐methyl‐tetralone using a series of D‐sources and tertiary amines as potential mediators. The…”
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On the specific rotation of deuterium-containing isotopomers of 2-dimethylaminocyclohexyl-1-trimethylammonium iodide by Coumbarides, Gregory S., Dingjan, Marco, Eames, Jason, Suggate, Michael J.

“…The specific rotation of a variety of differential isotopomers is reported. The difference in their specific rotation appears to be greater than their…”
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A convenient laboratory synthesis of deuterium-labelled trimethyl tetradecyl ammonium sulphate by Chavda, Sameer, Coumbarides, Gregory S., Dingjan, Marco, Eames, Jason, Zarbakhsh, Ali

“…A convenient and practical laboratory synthesis of deuterium‐labelled trimethyl tetradecyl ammonium sulphate is reported. Copyright © 2005 John Wiley & Sons,…”
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A practical laboratory route to the synthesis of trideuteriomethyl-[13C] iodide by Coumbarides, Gregory S., Eames, Jason, Weerasooriya, Neluka

“…A practical synthetic laboratory route for the synthesis of trideuteriomethyl‐[13C] iodide (13CD3I) (from tetradeuterio‐[13C]‐methanol and hydriodic acid) is…”
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Investigations into the C-deuteriation of enol acetates derived from aryl alkyl ketones by Buksha, Svitlana, Coumbarides, Gregory S., Dingjan, Marco, Eames, Jason, Suggate, Michael J., Weerasooriya, Neluka

“…Results are reported on the regioselective C‐deuteriation of a series of enol acetates (derived from the aryl alkyl ketones) using molecular deuterium as the…”
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The synthesis and characterisation of deuteriated amides by Coumbarides, Gregory S., Eames, Jason, Ghilagaber, Stephanos

“…Results are reported on the regioselective C‐deuteriation of a series of enolates derived from the addition of sec‐BuLi to a variety of substituted amides. The…”
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Investigations into the regioselective deuteriation of enolates derived from silyl enol ethers and enolacetates by Coumbarides, Gregory S., Eames, Jason, Weerasooriya, Neluka

“…Results are reported on the regioselective C‐deuteriation of a series of enolates derived from the addition of MeLi to the related enolacetate and silyl enol…”
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Investigations into the regioselective C-deuteriation of enolates using a diisopropylammonium salt by Coumbarides, Gregory S., Eames, Jason, Weerasooriya, Neluka

“…Results are reported on the regioselective C‐deuteriation of 2‐methyl tetralone using a series of diisopropylamine derived D‐sources. The results presented…”
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