Search Results - "Coulthard, Liam G"

Is the complement activation product C3a a proinflammatory molecule? Re-evaluating the evidence and the myth by Coulthard, Liam G, Woodruff, Trent M

“…The complement activation product C3a is often described as a proinflammatory mediator, alongside its downstream cousin, C5a. However, emerging studies show…”
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Complement dysregulation in the central nervous system during development and disease by Lee, John D., Coulthard, Liam G., Woodruff, Trent M.

“…•Complement proteins play essential roles in brain development.•Complement signalling can both protect against and aggravate neurological disease.•Complement…”
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C5L2: a controversial receptor of complement anaphylatoxin, C5a by Li, Rui, Coulthard, Liam G., Wu, M. C. L., Taylor, Stephen M., Woodruff, Trent M.

“…C5a is the paramount proinflammatory mediator of the complement cascade, and has been previously thought to act only through a single, G‐protein‐coupled, C5a…”
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Commentary: Beyond C4: Analysis of the complement gene pathway shows enrichment for IQ in patients with psychotic disorders and healthy controls by Coulthard, Liam G, Woodruff, Trent M

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Editorial: Complement in the Development and Regeneration of the Nervous System by Brennan, Faith H., Coulthard, Liam G., Alawieh, Ali M., Reiner, Orly, Pekna, Marcela

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Elevated complement factor C5a in maternal and umbilical cord plasma in preeclampsia by Denny, Kerina J, Coulthard, Liam G, Finnell, Richard H, Callaway, Leonie K, Taylor, Stephen M, Woodruff, Trent M

“…Abstract Preeclampsia is a leading cause of morbidity and mortality worldwide, encompassing significant short- and long-term health sequelae. Recently, there…”
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Complement: The Emerging Architect of the Developing Brain by Coulthard, Liam G., Hawksworth, Owen A., Woodruff, Trent M.

“…Complement activation products have long been associated with roles in the innate immune system, linking the humoral and cellular responses. However, among…”
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CSF-space volumetric change following posterior fossa decompression in paediatric Chiari type-I malformation: a correlation with outcome by Mantha, Sidharth, Coulthard, Liam G., Campbell, Robert

“…Objective We have previously reported inferior post-operative clinical outcomes in younger children with Chiari type-I malformation (CIM). We sought to…”
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Complement in stem cells and development by Hawksworth, Owen A., Coulthard, Liam G., Mantovani, Susanna, Woodruff, Trent M.

“…From its discovery in the late nineteenth century, as a ‘complement’ to the cellular immune response, the complement system has been widely affirmed as a…”
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Complement in the fundamental processes of the cell by Hawksworth, Owen A., Coulthard, Liam G., Woodruff, Trent M.

“…•Complement is an important driver of cellular functions outside of innate immunity.•Functions include migration, adhesion, morphogenesis, proliferation and…”
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New concepts on the therapeutic control of complement anaphylatoxin receptors by Hawksworth, Owen A., Li, Xaria X., Coulthard, Liam G., Wolvetang, Ernst J., Woodruff, Trent M.

“…•Complement underlies the pathogenesis of a vast number of inflammatory disorders.•Driving the complement inflammatory response are the anaphylatoxins, C5a and…”
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Complement C3a receptor modulates embryonic neural progenitor cell proliferation and cognitive performance by Coulthard, Liam G., Hawksworth, Owen A., Conroy, Jacinta, Lee, John D., Woodruff, Trent M.

“…•Complement C3aR is expressed on the apical ventricular zone in the developing mouse brain.•Pharmacological stimulation of C3aR reduces the proliferation of…”
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Complement C5aR1 Signaling Promotes Polarization and Proliferation of Embryonic Neural Progenitor Cells through PKCζ by Coulthard, Liam G, Hawksworth, Owen A, Li, Rui, Balachandran, Anushree, Lee, John D, Sepehrband, Farshid, Kurniawan, Nyoman, Jeanes, Angela, Simmons, David G, Wolvetang, Ernst, Woodruff, Trent M

“…The complement system, typically associated with innate immunity, is emerging as a key controller of nonimmune systems including in development, with recent…”
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Vagus nerve stimulation: a 20-year Australian experience by Yates, Charles F., Riney, Kate, Malone, Stephen, Shah, Ubaid, Coulthard, Liam G., Campbell, Robert, Wallace, Geoff, Wood, Martin

“…Background Vagus nerve stimulation (VNS) therapy was first approved in the mid-1990s in the USA, Europe and Australia, with demonstrable efficacy in paediatric…”
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Co-ordinated expression of innate immune molecules during mouse neurulation by Jeanes, Angela, Coulthard, Liam G, Mantovani, Susanna, Markham, Kathryn, Woodruff, Trent M

“…•Expression of innate immune molecules in the developing mouse occurs prior to the formation of a functional cellular immune system.•Expression of the central…”
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Brief Report: Complement C5a Promotes Human Embryonic Stem Cell Pluripotency in the Absence of FGF2 by Hawksworth, Owen A., Coulthard, Liam G., Taylor, Stephen M., Wolvetang, Ernst J., Woodruff, Trent M.

“…The complement activation product, C5a, is a pivotal member of the innate immune response; however, a diverse number of nonimmune functions are now being…”
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Ten-year statewide cross-sectional review of pediatric sinogenic intracranial abscess and empyema in Queensland, Australia: microbial profile before and after COVID-19 by Stuart, Michael J, Harbison, Annabelle M, Ma, Norman, Campbell, Robert A J, Jardim, Amelia J, Anderson, David S, Withers, Teresa K, Coulthard, Liam G

“…Sinogenic intracranial infections in children, such as subdural empyema or intracranial abscess, are a rare disease process with significant associated…”
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C5a receptor signaling prevents folate deficiency-induced neural tube defects in mice by Denny, Kerina J, Coulthard, Liam G, Jeanes, Angela, Lisgo, Steven, Simmons, David G, Callaway, Leonie K, Wlodarczyk, Bogdan, Finnell, Richard H, Woodruff, Trent M, Taylor, Stephen M

“…The complement system is involved in a range of diverse developmental processes, including cell survival, growth, differentiation, and regeneration. However,…”
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The Role of C5a Receptor Signaling in Endotoxin-Induced Miscarriage and Preterm Birth by Denny, Kerina J., Coulthard, Liam G., Mantovani, Susanna, Simmons, David, Taylor, Stephen M., Woodruff, Trent M.

“…Problem Complement factor 5a (C5a), a potent pro‐inflammatory mediator of the complement system, has been implicated in fetal rejection throughout gestation,…”
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Comparative efficacy of a secretory phospholipase A2 inhibitor with conventional anti-inflammatory agents in a rat model of antigen-induced arthritis by Coulthard, Liam G, Costello, Jaclyn, Robinson, Brent, Shiels, Ian A, Taylor, Stephen M, Woodruff, Trent M

“…Previously, secretory phospholipase A2 (sPLA2) inhibition has been used as an adjunct to conventional rheumatoid arthritis therapy in human clinical trials…”
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