Search Results - "Coulombe, R. A."

Structure, genetic mapping, and function of the cytochrome P450 3A37 gene in the turkey (Meleagris gallopavo) by Rawal, S, Mendoza, K M, Reed, K M, Coulombe, Jr, R A

“…Cytochromes P450 (P450 for protein; CYP for gene) are a superfamily of membrane-bound hemoproteins that oxidize a large number of endogenous and exogenous…”
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Effects of dietary butylated hydroxytoluene on aflatoxin B1-relevant metabolic enzymes in turkeys by Klein, P.J, Van Vleet, T.R, Hall, J.O, Coulombe, R.A., Jr

“…We have shown previously that the extreme sensitivity of turkeys to aflatoxin B(1) (AFB(1)) is due to a combination of efficient AFB(1) activation by…”
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Foliage physiology and biochemistry in response to light gradients in conifers with varying shade tolerance by Bond, B.J, Farnsworth, B.T, Coulombe, R.A, Winner, W.E

“…To examine the predictability of leaf physiology and biochemistry from light gradients within canopies, we measured photosynthetic light-response curves, leaf…”
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Nitrogen inputs best predict farm field nitrate leaching in the Willamette Valley, Oregon by Compton, J. E., Pearlstein, S. L., Erban, L., Coulombe, R. A., Hatteberg, B., Henning, A., Brooks, J. R., Selker, J. E.

“…Nitrate leaching is an important yet difficult to manage contribution to groundwater and surface water contamination in agricultural areas. We examined 14 farm…”
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Structure and genetic mapping of the Cytochrome P450 gene (CYP1A5) in the turkey (Meleagris gallopavo) by Reed, K M, Mendoza, K M, Coulombe, Jr, R A

“…Cytochromes P450 (P450) are a superfamily of membrane-bound hemoproteins that oxidize a large number of endogenous and exogenous compounds. The recently cloned…”
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Biological action of mycotoxins by Coulombe, Jr, R A

“…Mycotoxins are ubiquitous, mold-produced toxins that contaminate a wide variety of foods and feeds. Ingestion of mycotoxins cause a range of toxic responses,…”
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Pyrrolizidine Alkaloids Crosslink DNA with Actin by Coulombe, Roger A., Drew, Gail L., Stermitz, Frank R.

“…Pyrrolizidine alkaloids (PAs) are toxic constituents of hundreds of plant species, some of which people are exposed to in herbal products and traditional…”
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Comparative DNA Cross-linking by Activated Pyrrolizidine Alkaloids by Kim, H.-Y., Stermitz, F.R., Li, J.K.-K., Coulombe, R.A.

“…The toxicity and bioactivity of pyrrolizidine alkaloids (PAs), common constituents of hundreds of plant species, and in herbal remedies and folk medicines…”
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Inhibition of human cytochrome P450 2E1 by nicotine, cotinine, and aqueous cigarette tar extract in vitro by VAN VLEET, Terry R, BOMBICK, David W, COULOMBE, Roger A

“…Cigarette smoke is a complex mixture containing, among other chemicals, pyridine alkaloids and N-nitrosamines. Carcinogenic tobacco-specific N-nitrosamines,…”
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Aflatoxin B1 activation in human lung by KELLY, J. D, EATON, D. L, GUENGERICH, F. P, COULOMBE, R. A

“…Inhalation exposure to the carcinogen aflatoxin B1 (AFB1) in certain occupations is considerable. Because circumstantial epidemiological evidence suggests that…”
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Pyrrolizidine alkaloid-induced DNA-protein cross-links by Kim, H Y, Stermitz, F R, Coulombe, Jr, R A

“…Pyrrolizidine alkaloids (PAs) are potent carcinogenic and anti-mitotic compounds produced by a large number of plant species. In this study, we investigated in…”
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DNA cross-linking in mammalian cells by pyrrolizidine alkaloids: structure-activity relationships by Hincks, J R, Kim, H Y, Segall, H J, Molyneux, R J, Stermitz, F R, Coulombe, Jr, R A

“…Pyrrolizidine alkaloids (PAs) are common constituents of many species of flowering plants which possess carcinogenic as well as anticarcinogenic activity in…”
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Structural influences on pyrrolizidine alkaloid-induced cytopathology by Kim, H Y, Stermitz, F R, Molyneux, R J, Wilson, D W, Taylor, D, Coulombe, Jr, R A

“…Pyrrolizidine alkaloids (PAs), which are common constituents of hundreds of plant species around the world, have been reported to have cytotoxic, carcinogenic,…”
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Butylated hydroxytoluene chemoprevention of aflatoxicosis - Effects on aflatoxin B1 bioavailability, hepatic DNA adduct formation, and biliary excretion by Guarisco, J.A, Hall, J.O, Coulombe, R.A. Jr

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Pharmacokinetics of the antiviral agent 3-deazaneplanocin A by COULOMBE, R. A, SHARMA, R. P, HUGGINS, J. W

“…The pharmacokinetics of 3-deazaneplanocin A (c3Nep), a competitive inhibitor of S-adenosyl-L-homocysteine (AdoHcy) hydrolase and novel antiviral agent, was…”
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Comparative biotransformation of aflatoxin B1 in mammalian airway epithelium by Ball, R W, Coulombe, Jr, R A

“…Aflatoxin B1 (AFB1) appears to be a risk factor for upper respiratory tumors in individuals occupationally exposed to AFB1-contaminated grain dusts. To study…”
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Butylated hydroxytoluene chemoprevention of aflatoxicosis - effects on aflatoxin B(1) bioavailability, hepatic DNA adduct formation, and biliary excretion by Guarisco, J A, Hall, J O, Coulombe, Jr, R A

“…The extreme sensitivity of turkeys to aflatoxin B(1) (AFB(1)) is associated with efficient hepatic cytochrome P-450 (P450)-mediated bioactivation, and…”
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Biochemical basis for the extreme sensitivity of turkeys to aflatoxin B(1) by Klein, P J, Buckner, R, Kelly, J, Coulombe, Jr, R A

“…Poultry are the most susceptible food animal species to the toxic effects of the mycotoxin aflatoxin B(1) (AFB(1)). Feed contaminated with even small amounts…”
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Pharmacokinetics of the antiviral agent carbocyclic 3-deazaadenosine by Coulombe, Jr, R A, Huie, J M, Sharma, R P, Huggins, J W

“…The pharmacokinetics of carbocyclic 3-deazaadenosine (Cc3Ado), a competitive inhibitor of S-adenosyl-L-homocysteine hydrolase and novel antiviral agent, was…”
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Neurobiochemical alterations induced by the artificial sweetener aspartame (NutraSweet) by Coulombe, Jr, R A, Sharma, R P

“…The dipeptide aspartame (NutraSweet) is a newly approved and widely used artificial sweetener in foods and beverages. Consumption of aspartame (ASM) has been…”
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