Search Results - "Coulie, Pierre"

The determinants of tumour immunogenicity by Blankenstein, Thomas, Coulie, Pierre G., Gilboa, Eli, Jaffee, Elizabeth M.

“…Four leading tumour immunologists provide their opinions on the determinants of immunogenicity and how we might therapeutically improve tumour immunogenicity…”
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Facts and Hopes in Cancer Antigens Recognized by T Cells by Brochier, Walther, Bricard, Orian, Coulie, Pierre G

“…T cells are key effectors of our immune response against tumors and exert their antitumor effects upon recognizing a variety of tumor-specific peptides…”
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Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy by Coulie, Pierre G., Van den Eynde, Benoît J., van der Bruggen, Pierre, Boon, Thierry

“…In this Timeline, the authors discuss the identification of tumour antigens that are recognized by T lymphocytes and how these findings can be effectively and…”
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Integrating Next-Generation Dendritic Cell Vaccines into the Current Cancer Immunotherapy Landscape by Garg, Abhishek D, Coulie, Pierre G, Van den Eynde, Benoit J, Agostinis, Patrizia

“…Cancer immunotherapy is experiencing a renaissance spearheaded by immune checkpoint inhibitors (ICIs). This has spurred interest in ‘upgrading’ existing…”
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Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8 by Stockis, Julie, Liénart, Stéphanie, Colau, Didier, Collignon, Amandine, Nishimura, Stephen L., Sheppard, Dean, Coulie, Pierre G., Lucas, Sophie

“…Human regulatory T cells (Tregs) suppress other T cells by converting the latent, inactive form of TGF-β1 into active TGF-β1. In Tregs, TGF-β1 activation…”
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Membrane protein GARP is a receptor for latent TGF-β on the surface of activated human Treg by Stockis, Julie, Colau, Didier, Coulie, Pierre G, Lucas, Sophie

“…Human Treg and Th clones secrete the latent form of TGF-β, in which the mature TGF-β protein is bound to the latency-associated peptide (LAP), and is thereby…”
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Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer by de Streel, Grégoire, Bertrand, Charlotte, Chalon, Nicolas, Liénart, Stéphanie, Bricard, Orian, Lecomte, Sara, Devreux, Julien, Gaignage, Mélanie, De Boeck, Gitte, Mariën, Lore, Van De Walle, Inge, van der Woning, Bas, Saunders, Michael, de Haard, Hans, Vermeersch, Elien, Maes, Wim, Deckmyn, Hans, Coulie, Pierre G., van Baren, Nicolas, Lucas, Sophie

“…TGF-β1, β2 and β3 bind a common receptor to exert vastly diverse effects in cancer, supporting either tumor progression by favoring metastases and inhibiting…”
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Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo by Cuende, Julia, Liénart, Stéphanie, Dedobbeleer, Olivier, van der Woning, Bas, De Boeck, Gitte, Stockis, Julie, Huygens, Caroline, Colau, Didier, Somja, Joan, Delvenne, Philippe, Hannon, Muriel, Baron, Frédéric, Dumoutier, Laure, Renauld, Jean-Christophe, De Haard, Hans, Saunders, Michael, Coulie, Pierre G, Lucas, Sophie

“…Regulatory T cells (Tregs) are essential to prevent autoimmunity, but excessive Treg function contributes to cancer progression by inhibiting antitumor immune…”
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Neogenesis of Lymphoid Structures and Antibody Responses Occur in Human Melanoma Metastases by CIPPONI, Arcadi, MERCIER, Marjorie, SEREMET, Teofila, BAURAIN, Jean-François, THEATE, Ivan, VAN DEN OORD, Joost, STAS, Marguerite, BOON, Thierry, COULIE, Pierre G, VAN BAREN, Nicolas

“…Lymphoid neogenesis, or the development of lymphoid structures in nonlymphoid organs, is frequently observed in chronically inflamed tissues, during the course…”
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Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells by Liénart, Stéphanie, Merceron, Romain, Vanderaa, Christophe, Lambert, Fanny, Colau, Didier, Stockis, Julie, van der Woning, Bas, De Haard, Hans, Saunders, Michael, Coulie, Pierre G, Savvides, Savvas N, Lucas, Sophie

“…Transforming growth factor-β1 (TGF-β1) is one of very few cytokines produced in a latent form, requiring activation to exert any of its vastly diverse effects…”
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Cutting Edge: Active TGF-β1 Released from GARP/TGF-β1 Complexes on the Surface of Stimulated Human B Lymphocytes Increases Class-Switch Recombination and Production of IgA by Dedobbeleer, Olivier, Stockis, Julie, van der Woning, Bas, Coulie, Pierre G, Lucas, Sophie

“…Production of active TGF-β is regulated at a posttranslational level and implies release of the mature cytokine dimer from the inactive, latent TGF-β…”
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Intraoperative ketorolac in high-risk breast cancer patients. A prospective, randomized, placebo-controlled clinical trial by Forget, Patrice, Bouche, Gauthier, Duhoux, Francois P, Coulie, Pierre G, Decloedt, Jan, Dekleermaker, Alain, Guillaume, Jean-Edouard, Ledent, Marc, Machiels, Jean-Pascal, Mustin, Véronique, Swinnen, Walter, van Maanen, Aline, Vander Essen, Lionel, Verougstraete, Jean-Christophe, De Kock, Marc, Berliere, Martine

“…Ketorolac has been associated with a lower risk of recurrence in retrospective studies, especially in patients with positive inflammatory markers. It is still…”
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Pandemic chilblains: Are they SARS-CoV-2-related or not? by De Greef, Axel, Coulie, Pierre G., Baeck, Marie

“…The exact etiopathology of chilblains observed during the Coronavirus Disease 2019 (COVID-19) pandemic is still unclear. Initially, SARS-CoV-2 appeared as the…”
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An innovative plasmacytoid dendritic cell line-based cancer vaccine primes and expands antitumor T-cells in melanoma patients in a first-in-human trial by Charles, Julie, Chaperot, Laurence, Hannani, Dalil, Bruder Costa, Juliana, Templier, Isabelle, Trabelsi, Sabiha, Gil, Hugo, Moisan, Anaick, Persoons, Virginie, Hegelhofer, Harald, Schir, Edith, Quesada, Jean-Louis, Mendoza, Christophe, Aspord, Caroline, Manches, Olivier, Coulie, Pierre G., Khammari, Amir, Dreno, Brigitte, Leccia, Marie-Thérèse, Plumas, Joel

“…The efficacy of immune checkpoint inhibitors has been shown to depend on preexisting antitumor immunity; thus, their combination with cancer vaccines is an…”
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Natural Human Plasmacytoid Dendritic Cells Induce Antigen-Specific T-Cell Responses in Melanoma Patients by TEL, Jurjen, AARNTZEN, Erik H. J. G, WINKELS, Gregor, COULIE, Pierre G, PUNT, Cornelis J. A, FIGDOR, Carl G, DE VRIES, I. Jolanda M, BABA, Tetsuro, SCHREIBELT, Gerty, SCHULTE, Barbara M, BENITEZ-RIBAS, Daniel, BOERMAN, Otto C, CROOCKEWIT, Sandra, OYEN, Wim J. G, VAN ROSSUM, Michelle

“…Vaccination against cancer by using dendritic cells has for more than a decade been based on dendritic cells generated ex vivo from monocytes or CD34(+)…”
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Neutrophil:Lymphocyte Ratio and Intraoperative Use of Ketorolac or Diclofenac are Prognostic Factors in Different Cohorts of Patients Undergoing Breast, Lung, and Kidney Cancer Surgery by Forget, Patrice, Machiels, Jean-Pascal, Coulie, Pierre G., Berliere, Martine, Poncelet, Alain J., Tombal, Bertrand, Stainier, Annabelle, Legrand, Catherine, Canon, Jean-Luc, Kremer, Yann, De Kock, Marc

“…Background Inflammation is associated with a worse outcome in cancer and neutrophil:lymphocyte ratio (NLR) is a strong prognostic value. In cancer,…”
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Role of Akt/PKB and PFKFB isoenzymes in the control of glycolysis, cell proliferation and protein synthesis in mitogen-stimulated thymocytes by Houddane, Amina, Bultot, Laurent, Novellasdemunt, Laura, Johanns, Manuel, Gueuning, Marie-Agnès, Vertommen, Didier, Coulie, Pierre G., Bartrons, Ramon, Hue, Louis, Rider, Mark H.

“…Proliferating cells depend on glycolysis mainly to supply precursors for macromolecular synthesis. Fructose 2,6-bisphosphate (Fru-2,6-P2) is the most potent…”
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Therapeutic activity of GARP:TGF-β1 blockade in murine primary myelofibrosis by Lecomte, Sara, Devreux, Julien, de Streel, Grégoire, van Baren, Nicolas, Havelange, Violaine, Schröder, David, Vaherto, Noora, Vanhaver, Christophe, Vanderaa, Christophe, Dupuis, Noémie, Pecquet, Christian, Coulie, Pierre G., Constantinescu, Stefan N., Lucas, Sophie

“…•Anti-GARP:TGF-β1 mAb exerts antitumor activity in myeloproliferative neoplasms by selectively blocking Treg-derived TGF-β1.•Targeting Treg functions is…”
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Antigen Spreading Contributes to MAGE Vaccination-Induced Regression of Melanoma Metastases by CORBIERE, Véronique, CHAPIRO, Jacques, STROOBANT, Vincent, WENBIN MA, LURQUIN, Christophe, LETHE, Bernard, VAN BAREN, Nicolas, VAN DEN EYNDE, Benoît J, BOON, Thierry, COULIE, Pierre G

“…A core challenge in cancer immunotherapy is to understand the basis for efficacious vaccine responses in human patients. In previous work we identified a…”
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Blocking GARP-mediated activation of TGF-β1 did not alter innate or adaptive immune responses to bacterial infection or protein immunization in mice by Gaignage, Mélanie, Zhang, Xuhao, Stockis, Julie, Dedobbeleer, Olivier, Michiels, Camille, Cochez, Perrine, Dumoutier, Laure, Coulie, Pierre G., Lucas, Sophie

“…Transmembrane protein GARP binds latent TGF-β1 to form GARP:(latent)TGF-β1 complexes on the surface of several cell types including Tregs, B-cells, and…”
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