Search Results - "Coughtrie, Michael W. H."

Quantitative Evaluation of the Expression and Activity of Five Major Sulfotransferases (SULTs) in Human Tissues: The SULT Pie by RICHES, Zoe, STANLEY, Emma L, BLOOMER, Jackie C, COUGHTRIE, Michael W. H

“…Expression levels of the major human sulfotransferases (SULTs) involved in xenobiotic detoxification in a range of human tissues (i.e., SULT "pies") are not…”
Get full text

Epigenetics: methylation-associated repression of heparan sulfate 3-O-sulfotransferase gene expression contributes to the invasive phenotype of H-EMC-SS chondrosarcoma cells by Bui, Catherine, Ouzzine, Mohamed, Talhaoui, Ibtissam, Sharp, Sheila, Prydz, Kristian, Coughtrie, Michael W.H, Fournel-Gigleux, Sylvie

“…Heparan sulfate proteoglycans (HSPGs), strategically located at the cell-tissue-organ interface, regulate major biological processes, including cell…”
Get full text

Homology Modeling of Human Uridine-5′-diphosphate-glucuronosyltransferase 1A6 Reveals Insights into Factors Influencing Substrate and Cosubstrate Binding by Smith, Alexander D, Page, Brent D. G, Collier, Abby C, Coughtrie, Michael W. H

“…The elimination of numerous endogenous compounds and xenobiotics via glucuronidation by uridine-5′-diphosphate glycosyltransferase enzymes (UGTs) is an…”
Get full text

A Novel Method for the Immunoquantification of UDP-Glucuronosyltransferases in Human Tissue by MILNE, Alison M, BURCHELL, Brian, COUGHTRIE, Michael W. H

“…Glucuronidation is a major pathway of drug and xenobiotic metabolism that is catalyzed by members of the UDP-glucuronosyltransferase (UGT) family. Predicting…”
Get full text

Protective placental inflammatory and oxidative stress responses are attenuated in the context of twin pregnancy and chorioamnionitis in assisted reproduction by Price, Hayley R., Pang, Nick, Kim, Hugh, Coughtrie, Michael W. H., Collier, Abby C.

“…Purpose Assisted reproduction technologies (ART) are associated with increased risks of pregnancy complications and obstetric interventions. Here, we aimed to…”
Get full text

Coexpression of Human Hepatic Uridine Diphosphate Glucuronosyltransferase Proteins: Implications for Ontogenetic Mechanisms and Isoform Coregulation by Liu, Yuejian, Badée, Justine, Takahashi, Ryan H., Schmidt, Stephan, Parrott, Neil, Fowler, Stephen, Mackenzie, Peter I., Coughtrie, Michael W. H., Collier, Abby C.

“…Uridine diphosphate glucuronosyltransferases (UGTs) catalyze glucuronidation to facilitate systemic and local clearance of numerous chemicals and drugs. To…”
Get full text

Molecular and functional characterization of microsomal UDP-glucuronic acid uptake by members of the nucleotide sugar transporter (NST) family by Kobayashi, Tsutomu, Sleeman, Judith E, Coughtrie, Michael W H, Burchell, Brian

“…Transport of the co-substrate UDPGA (UDP-glucuronic acid) into the lumen of the endoplasmic reticulum is an essential step in glucuronidation reactions due to…”
Get full text

Absolute immunoquantification of the expression of ABC transporters P-glycoprotein, breast cancer resistance protein and multidrug resistance-associated protein 2 in human liver and duodenum by Tucker, Theodora G.H.A., Milne, Alison M., Fournel-Gigleux, Sylvie, Fenner, Katherine S., Coughtrie, Michael W.H.

“…The ATP-binding cassette (ABC) transporters breast cancer resistance protein (BCRP), multidrug resistance-associated protein 2 (MRP2), and P-glycoprotein (Pgp)…”
Get full text

Revisiting the Latency of Uridine Diphosphate-Glucuronosyltransferases (UGTs)-How Does the Endoplasmic Reticulum Membrane Influence Their Function? by Liu, Yuejian, Coughtrie, Michael W H

“…Uridine diphosphate-glucuronosyltransferases (UGTs) are phase 2 conjugation enzymes mainly located in the endoplasmic reticulum (ER) of the liver and many…”
Get full text

CONJUGATION OF CATECHOLS BY RECOMBINANT HUMAN SULFOTRANSFERASES, UDP-GLUCURONOSYLTRANSFERASES, AND SOLUBLE CATECHOL O-METHYLTRANSFERASE: STRUCTURE-CONJUGATION RELATIONSHIPS AND PREDICTIVE MODELS by TASKINEN, Jyrki, ETHELL, Brian T, PIHLAVISTO, Pia, HOOD, Alan M, BURCHELL, Brian, COUGHTRIE, Michael W. H

“…Conjugation of a structurally diverse set of 53 catechol compounds was studied in vitro using six recombinant human sulfotransferases (SULTs), five…”
Get full text

Plasma Catecholamines and the Counterregulatory Responses to Hypoglycemia in Infants: A Critical Role for Epinephrine and Cortisol by Jackson, Lesley, Williams, Fiona L. R., Burchell, Ann, Coughtrie, Michael W. H., Hume, Robert

“…The purpose of this study was to define plasma catecholamine responses as part of the counterregulatory hormonal reaction to hypoglycemia in infants after a…”
Get full text

Metabolism of the Cancer Chemopreventive Agent Curcumin in Human and Rat Intestine by IRESON, Christopher R, JONES, Donald J. L, ORR, Samantha, COUGHTRIE, Michael W. H, BOOCOCK, David J, WILLIAMS, Marion L, FARMER, Peter B, STEWARD, William P, GESCHER, Andreas J

“…Curcumin, the yellow pigment in turmeric, prevents malignancies in the intestinal tract of rodents. It is under clinical evaluation as a potential colon cancer…”
Get full text

Sulfotransferase activities towards xenobiotics and estradiol in two marine fish species ( Mullus barbatus and Lepidorhombus boscii): Characterization and inhibition by endocrine disrupters by Martin-Skilton, Rebeca, Coughtrie, Michael W.H., Porte, Cinta

“…We have characterized hepatic phenol sulfotransferase (SULT) activities in two benthic fish species, Mullus barbatus and Lepidorhombus boscii, using…”
Get full text

Protocol for the smoking, nicotine and pregnancy (SNAP) trial: double-blind, placebo-randomised, controlled trial of nicotine replacement therapy in pregnancy by Coleman, Tim, Thornton, Jim, Britton, John, Lewis, Sarah, Watts, Kim, Coughtrie, Michael W H, Mannion, Clare, Marlow, Neil, Godfrey, Christine

“…Smoking in pregnancy remains a public health challenge. Nicotine replacement therapy (NRT) is effective for smoking cessation in non-pregnant people, but…”
Get full text

Function and organization of the human cytosolic sulfotransferase (SULT) family by Coughtrie, Michael W.H.

“…The sulfuryl transfer reaction is of fundamental biological importance. One of the most important manifestations of this process are the reactions catalyzed by…”
Get full text

N-glucuronidation of carbamazepine in human tissues is mediated by UGT2B7 by Staines, Adam G, Coughtrie, Michael W H, Burchell, Brian

“…Carbamazepine (CBZ) is one of the most widely prescribed anticonvulsants despite a high incidence of idiosyncratic side effects. Metabolism of CBZ is complex,…”
Get more information

Characterization of rat iodothyronine sulfotransferases by Kester, Monique H A, Kaptein, Ellen, Roest, Thirza J, van Dijk, Caren H, Tibboel, Dick, Meinl, Walter, Glatt, Hansruedi, Coughtrie, Michael W H, Visser, Theo J

“…Sulfation appears to be an important pathway for the reversible inactivation of thyroid hormone during fetal development. The rat is an often used animal model…”
Get more information

Chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) involved in chondroitin sulfate initiation: Impact of sulfation on activity and specificity by Gulberti, Sandrine, Jacquinet, Jean-Claude, Chabel, Matthieu, Ramalanjaona, Nick, Magdalou, Jacques, Netter, Patrick, Coughtrie, Michael W H, Ouzzine, Mohamed, Fournel-Gigleux, Sylvie

“…Glycosaminoglycan (GAG) assembly initiates through the formation of a linkage tetrasaccharide region serving as a primer for both chondroitin sulfate (CS) and…”
Get full text

Potent Inhibition of Estrogen Sulfotransferase by Hydroxylated PCB Metabolites: A Novel Pathway Explaining the Estrogenic Activity of PCBs by Kester, Monique H. A, Bulduk, Sema, Tibboel, Dick, Meinl, Walter, Glatt, Hansruedi, Falany, Charles N, Coughtrie, Michael W. H, Bergman, Ake, Safe, Stephen H, Kuiper, George G. J. M, Schuur, A. Gerlienke, Brouwer, Abraham, Visser, Theo J

“…ABSTRACT Polychlorinated biphenyls (PCBs) are persistent environmental pollutants which exert a variety of toxic effects in animals, including disturbances of…”
Get full text

Luminal accumulation of newly synthesized morphine-3-glucuronide in rat liver microsomal vesicles by Révész, Katalin, Tóth, Blanka, Staines, Adam G., Coughtrie, Michael W. H., Mandl, József, Csala, Miklós

“…Morphine is converted to morphine 3‐β‐D‐glucuronide (M3G) by the UDP‐glucuronosyltransferase Ugt2b1 in the endoplasmic reticulum (ER) of rat liver. Because of…”
Get full text