Search Results - "Coughlin, S. R"

Cardiovascular and metabolic effects of CPAP in obese males with OSA by Coughlin, S. R, Mawdsley, L, Mugarza, J. A, Wilding, J. P. H, Calverley, P. M. A

“…Obstructive sleep apnoea is associated with increased blood pressure and other features of the metabolic syndrome. The aim of the present study was to…”
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Protease‐activated receptors in hemostasis, thrombosis and vascular biology by COUGHLIN, S. R.

“…The coagulation cascade and protease‐activated receptors (PARs) together provide an elegant mechanism that links mechanical information in the form of tissue…”
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Atherosclerosis proceeds independently of thrombin-induced platelet activation in ApoE −/− mice by Hamilton, J.R, Cornelissen, I, Mountford, J.K, Coughlin, S.R

“…Abstract Platelet activation has long been postulated to contribute to the development of atherosclerotic plaques, although the mechanism by which this might…”
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PAR3 is a cofactor for PAR4 activation by thrombin by Coughlin, Shaun R, Nakanishi-Matsui, Mayumi, Zheng, Yao-Wu, Sulciner, David J, Weiss, Ethan J, Ludeman, Matthew J

“…Identification of the mechanisms by which the coagulation protease thrombin activates platelets is critical for understanding haemostasis and thrombosis…”
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A Role for Thrombin Receptor Signaling in Endothelial Cells during Embryonic Development by Griffin, Courtney T., Srinivasan, Yoga, Zheng, Yao-Wu, Huang, Wei, Coughlin, Shaun R.

“…The coagulation protease thrombin triggers fibrin formation, platelet activation, and other cellular responses at sites of tissue injury. We report a role for…”
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Molecular Cloning and Functional Expression of Two Monocyte Chemoattractant Protein 1 Receptors Reveals Alternative Splicing of the Carboxyl-Terminal Tails by Charo, Israel F., Myers, Scott J., Herman, Ann, Franci, Christian, Connolly, Andrew J., Coughlin, Shaun R.

“…Monocyte chemoattractant protein 1 (MCP-1) is a member of the chemokine family of cytokines that mediate leukocyte chemotaxis. The potent and specific…”
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A dual thrombin receptor system for platelet activation by Coughlin, Shaun R, Kahn, Mark L, Zheng, Yao-Wu, Huang, Wei, Bigornia, Violeta, Zeng, Dewan, Moff, Stephen, Farese, Robert V, Tam, Carmen

“…Platelet-dependent arterial thrombosis triggers most heart attacks and strokes. Because the coagulation protease thrombin is the most potent activator of…”
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Protease-activated receptor 3 is a second thrombin receptor in humans by Ishihara, Hiroaki, Connolly, Andrew J, Zeng, Dewan, Kahn, Mark L, Wu Zheng, Yao, Timmons, Courtney, Tram, Tracy, Coughlin, Shaun R

“…Thrombin is a coagulation protease that activates platelets, leukocytes, endothelial and mesenchymal cells at sites of vascular injury, acting partly through…”
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Delayed Onset of Inflammation in Protease-Activated Receptor-2-Deficient Mice by Lindner, Jonathan R, Kahn, Mark L, Coughlin, Shaun R, Sambrano, Gilberto R, Schauble, Eric, Bernstein, Daniel, Foy, Dan, Hafezi-Moghadam, Ali, Ley, Klaus

“…Endothelial surface expression of P-selectin and subsequent leukocyte rolling in venules can be induced by mast cell-derived histamine and binding of thrombin…”
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Monocyte chemoattractant protein-1 in human atheromatous plaques by NELKEN, N. A, COUGHLIN, S. R, GORDON, D, WILCOX, J. N

“…Monocytes appear to be central to atherogenesis both as the progenitors of foam cells and as a potential source of growth factors mediating intimal…”
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Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor by MCNAMARA, C. A, SAREMBOCK, I. J, GIMPLE, L. W, FENTON, J. W, COUGHLIN, S. R, OWENS, G. K

“…Thrombin has been implicated in the stimulation of smooth muscle cell (SMC) proliferation that contributes to post angioplasty restenosis. The present studies…”
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Role of the thrombin receptor in development and evidence for a second receptor by Connolly, Andrew J, Ishihara, Hiroaki, Kahn, Mark L, Farese, Robert V, Coughlin, Shaun R

“…Thrombin, a coagulation protease generated at sites of vascular injury, activates platelets, endothelial cells, leukocytes and mesenchymal cells. A…”
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Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases by ISHII, K, JI CHEN, ISHII, M, KOCH, W. J, FREEDMAN, N. J, LEFKOWITZ, R. J, COUGHLIN, S. R

“…The thrombin receptor, a member of the seven membrane-spanning superfamily of G-protein coupled receptors, is activated by an irreversible proteolytic…”
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Characterization of a functional thrombin receptor : issues and opportunities by COUGHLIN, S. R, VU, T.-K. H, HUNG, D. T, WHEATON, V. I

“…In this Perspectives, we review the recent cloning and characterization of a platelet thrombin receptor in our laboratory. Identification of the thrombin…”
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The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase by HUNG, D. T, WONG, Y. H, VU, T.-K. H, COUGHLIN, S. R

“…Thrombin both stimulates phosphoinositide hydrolysis and inhibits adenylyl cyclase in a variety of cell types. Whether the cloned human platelet thrombin…”
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Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling by ISHII, K, HEIN, L, KOBILKA, B, COUGHLIN, S. R

“…Thrombin, a protease generated at sites of vascular injury, signals cellular responses vital for hemostasis and thrombosis. How thrombin, an enzyme rather than…”
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Protease-Activated Receptors Start a Family by Coughlin, Shaun R.

“…The cloning of a new protease-activated receptor that is closely related to the thrombin receptor is reported. The evidence for the mechanism of receptor…”
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Thrombin receptor activation. Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode by JI CHEN, ISHII, M, WANG, L, ISHII, K, COUGHLIN, S. R

“…Cleavage of the thrombin receptor's amino-terminal exodomain at the Arg41/Ser42 peptide bond within the sequence ... LDPR41/S42FLLRN ... is necessary and…”
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Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function by SCARBOROUGH, R. M, NAUGHTON, M. A, TENG, W, HUNG, D. T, ROSE, J, VU, T.-K. H, WHEATON, V. I, TURCK, C. W, COUGHLIN, S. R

“…The human platelet thrombin receptor is activated when thrombin cleaves its receptor's amino-terminal extension to reveal a new amino terminus that functions…”
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Thrombin receptor expression in normal and atherosclerotic human arteries by NELKEN, N. A, SOIFER, S. J, O'KEEFE, J, VU, T.-K. H, CHARO, I. F, COUGHLIN, S. R

“…Thrombin is a multifunctional serine protease generated at sites of vascular injury. A host of thrombin actions on vascular endothelial cells, smooth muscle…”
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