Search Results - "Coughlin, S A"

A multiprotein form of DNA polymerase alpha from HeLa cells. Resolution of its associated catalytic activities by Vishwanatha, J K, Coughlin, S A, Wesolowski-Owen, M, Baril, E F

“…The majority of the DNA polymerase alpha activity in HeLa cells has been isolated and purified as a multiprotein Mr 640,000 form. The multiprotein form of DNA…”
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Synthesis and Antitumor Activity of 4-Aminomethylthioxanthenone and 5-Aminomethylbenzothiopyranoindazole Derivatives by Perni, Robert B, Wentland, Mark P, Huang, Jianhua I, Powles, Ronald G, Aldous, Suzanne, Klingbeil, Kristina M, Peverly, A. Danielle, Robinson, Ronald G, Corbett, Thomas H, Jones, Julie L, Mattes, Kenneth C, Rake, James B, Coughlin, Susan A

“…Two new series of antitumor agents, 4-aminomethylthioxanthenones (6 − 50) and 5-aminomethylbenzothiopyranoindazoles (51 − 61), are described and compared…”
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Carcinoid in canine large intestine by Coughlin, A S

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DNA sequence preferences at sites cleaved by human DNA topoisomerase II in response to novel quinolone derivatives by Huff, A C, Robinson, R G, Evans, A C, Selander, K N, Wentland, M P, Rake, J B, Coughlin, S A

“…We have examined the DNA cleavage site specificity of human type II DNA topoisomerase in the presence of each of five novel quinolone derivatives. Each…”
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Air temperatures at Armagh Observatory, Northern Ireland, from 1796 to 2002 by Butler, C. J., García Suárez, A. M., Coughlin, A. D. S., Morrell, C.

“…Three independent mean temperature series for Armagh Observatory, covering the period 1796–2002 have been calibrated and corrected for the time of reading and…”
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Two-dimensional zymogram analysis of nucleases in Bacillus subtilis by Coughlin, S A, Green, D M

“…A two-dimensional zymogram procedure for the analysis of nucleases is described. Isoelectric focusing (IEF) and nonequilibrium pH gradient electrophoresis…”
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Mammalian topoisomerase II inhibitory activity of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and related derivatives by Wentland, Mark P, Lesher, George Y, Reuman, Michael, Gruett, Monte D, Singh, Baldev, Aldous, Suzanne C, Dorff, Peter H, Rake, James B, Coughlin, Susan A

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Isolation and characterization of monoclonal antibodies to a recombinant human topoisomerase II polypeptide by Robinson, R G, Rapp, L, Bowdish, K J, Graham, M A, Huff, A C, Coughlin, S A

“…We have produced two murine monoclonal antibodies (SWT3D1 and SWR1C2) to a recombinant polypeptide corresponding to the carboxyl-terminal one-third (amino acid…”
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Mechanism of action and antitumor activity of (S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyridol[1,2,3-de]-[1,4]benzothiazine-6-carboxylic acid (WIN 58161) by COUGHLIN, S. A, DANZ, D. W, RAKE, J. B, ROBINSON, R. G, KLINGBEIL, K. M, WENTLAND, M. P, CORBETT, T. H, WAUD, W. R, ZWELLING, L. A, ALTSCHULER, E, BALES, E

“…(S)-10-(2,6-Dimethyl-4-pyridinyl) 9-fluoro-3-methyl-7-oxo 2,3-dihydro-7H-pyrido[1,2,3-de] [1,4]benzothiazine-6-carboxylic acid (WIN 58161) is an…”
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Synthesis and Antibacterial Activity of Some Novel 1-Substituted 1,4-Dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic Acids. Potent Antistaphylococcal Agents by Reuman, Michael, Daum, Sol J, Singh, Baldev, Wentland, Mark P, Perni, Robert B, Pennock, Patrick, Carabateas, Philip M, Gruett, Monte D, Saindane, Manohar T, Dorff, Peter H, Coughlin, Susan A, Sedlock, David M, Rake, James B, Lesher, George Y

“…The palladium-catalyzed coupling of 3- and 4-(trialkylstannyl)pyridines with 7-bromo or 7-chloro 1-substituted 1,4-dihydro-4-oxo-3-quinolinecarboxylates has…”
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5',5'''-P1, P4 diadenosine tetraphosphate (Ap4A): a putative initiator of DNA replication by Baril, E F, Coughlin, S A, Zamecnik, P C

“…The proposal that Ap4A acts as an inducer of DNA replication is based primarily on two pieces of evidence (7). The intracellular levels of Ap4A increase ten-…”
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Mammalian topoisomerase II inhibitory activity of 1-cyclopropyl-6,8- difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarb oxylic acid and related derivatives by Wentland, M P, Lesher, G Y, Reuman, M, Gruett, M D, Singh, B, Aldous, S C, Dorff, P H, Rake, J B, Coughlin, S A

“…1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-ox o-3-quinolinecarboxylic acid (1), a previously reported potent inhibitor of bacterial…”
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Mechanism of action and antitumor activity of ( S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7 H-pyridol [1,2,3- de]-[1,4]benzothiazine-6-carboxylic acid (WIN 58161) by Coughlin, Susan A., Danz, Deborah W., Robinson, Ronald G., Klingbeil, Kristina M., Wentland, Mark P., Corbett, Thomas H., Waud, William R., Zwelling, Leonard A., Altschuler, Elizabeth, Bales, Elise, Rake, James B.

“…( S)-10-(2,6-Dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7 H-pyrido[1,2,3 de][1,4] benzothiazine-6-carboxylic acid (WIN 58161) is an…”
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Precipitation at Armagh Observatory 1838-1997 by Butler, C. J., Coughlin, A. D. S., Fee, D. T.

“…The meteorological series maintained at Armagh Observatory began in 1795 and are the longest in Ireland and among the longest in the British Isles. Here we…”
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The antitumor activity of novel pyrazoloquinoline derivatives by Wentland, Mark P., Aldous, Suzanne C., Gruett, Monte D., Perni, Robert B., Powles, Ronald G., Danz, Deborah W., Klingbeil, Kristina M., Peverly, A.Danielle, Robinson, Ronald G., Corbett, Thomas H., Rake, James B., Coughlin, Susan A.

“…Mammalian topoisomerase II inhibition activity has been identified in a series of novel pyrazoloquinoline derivatives; potency for two analogues containing…”
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3-benzyl-quinolones: Novel, potent inhibitors of mammalian topoisomerase II by Eissenstat, Michael A., Kuo, Gee-Hong, Weaver, John D., Wentland, Mark P., Robinson, Ronald G., Klingbeil, Kristina M., Danz, Deborah W., Corbett, Thomas H., Coughlin, Susan A.

“…Replacement of the 3-carboxy group of quinolone topoisomerase II inhibitors by hydroxy substituted benzyl groups resulted in potent topoisomerase II…”
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Cyclic variations of SR 233377 (WIN 33377) and effects on antitumor activity by Wentland, Mark P., Perni, Robert B., Huang, Jianhua I., Powles, Ronald G., Aldous, Suzanne C., Klingbeil, Kristina M., Danielle Peverly, A., Robinson, Ronald G., Corbett, Thomas H., Jones, Julie L., Rake, James B., Coughlin, Susan A.

“…Novel derivatives of SR 233377 ( 1, WIN 33377) where a pyrazolo ring fusion has been incorporated at the 1- and 9-positions of the thioxanthone ring displayed…”
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Potent mammalian topoisomerase II inhibitors: 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-substituted-quinolines by Kuo, Gee-Hong, Eissenstat, Michael A., Wentland, Mark P., Robinson, Ron G., Klingbeil, Kristina M., Danz, Debbie W., Coughlin, Susan A.

“…A series of novel 4-substituted-1,4-dihydro-quinolines 3 were prepared and found to exhibit moderate to excellent mammalian topo II inhibitory activity. Among…”
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