Search Results - "Coughlin, John"

Plasma Trimethylamine N -Oxide, a Gut Microbe–Generated Phosphatidylcholine Metabolite, Is Associated With Atherosclerotic Burden by Senthong, Vichai, MD, Li, Xinmin S., PhD, Hudec, Timothy, BS, Coughlin, John, BS, Wu, Yuping, PhD, Levison, Bruce, PhD, Wang, Zeneng, PhD, Hazen, Stanley L., MD, PhD, Tang, W.H. Wilson, MD

“…Abstract Background Trimethylamine N -oxide (TMAO), a gut microbiota metabolite from dietary phosphatidylcholine, has mechanistic links to atherosclerotic…”
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Evaluation of the impact of antibody fragments on aggregation of intact molecules via size exclusion chromatography coupled with native mass spectrometry by Xu, Jing, Coughlin, John E, Szyjka, Malgorzata, Jabary, Serene, Saluja, Sonal, Sosic, Zoran, Chen, Yunqiu, Xu, Chong-Feng

“…Aggregates are recognized as one of the most critical product-related impurities in monoclonal antibody (mAb)-based therapeutics due to their negative impact…”
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Assessment of the role of afucosylated glycoforms on the in vitro antibody-dependent phagocytosis activity of an antibody to Aβ aggregates by Kwiatkowski, Allyson, Co, Carl, Kameoka, Sei, Zhang, An, Coughlin, John, Cameron, Tom, Chiao, Eric, Bergelson, Svetlana, Schmid Mason, Cullen

“…The terminal sugars of Fc glycans can influence the Fc-dependent biological activities of monoclonal antibody therapeutics. Afucosylated N-glycans have been…”
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Metabolism, pharmacokinetics, tissue distribution, and stability studies of the prodrug analog of an anti-hepatitis B virus dinucleoside phosphorothioate by Coughlin, John E, Pandey, Rajendra K, Padmanabhan, Seetharamaiyer, O'Loughlin, Kathleen G, Marquis, Judith, Green, Carol E, Mirsalis, Jon C, Iyer, Radhakrishnan P

“…The alkoxycarbonyloxy dinucleotide prodrug R(p), S(p)-2 is an orally bioavailable anti-hepatitis B virus agent. The compound is efficiently metabolized to the…”
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Separation, Cooperation, and Human Dignity in Church-State Relations by Coughlin, John J

“…The Catholic understanding of the proper relation between church and state has developed in light of three interrelated principles. First, the separation…”
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Synthesis of a 35S-labeled dinucleoside phosphorothioate prodrug, an orally bioavailable anti-HBV agent by Rhee, Sung-Whi, Iyer, Radhakrishnan P., Coughlin, John E., Padmanabhan, Seetharamaiyer, Malerich, Jeremiah P., Tanga, Mary J.

“…The 35S‐labeled, dinucleoside phosphorothioate 1, an orally available agent against hepatitis B virus, was prepared in eight steps with high specific activity…”
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Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs by Coughlin, John E., Padmanabhan, Seetharamaiyer, Zhang, Guangrong, Kirk, Cassandra J., Govardhan, Chandrika P., Korba, Brent E., O’Loughlin, Kathleen, Green, Carol E., Mirsalis, Jon, Morrey, John D., Iyer, Radhakrishnan P.

“…Novel acyloxyalkyl dinucleotide prodrugs have been developed as orally bioavailable anti-HBV agents. The acyloxyalkyl derivatives of a model anti-HBV…”
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Anti-HBV nucleotide prodrug analogs: Synthesis, bioreversibility, and cytotoxicity studies by Padmanabhan, Seetharamaiyer, Coughlin, John E., Zhang, Guangrong, Kirk, Cassandra J., Iyer, Radhakrishnan P.

“…Synthesis and evaluation of a number of dinucleotide prodrugs are described. Several pronucleotide analogs of the model anti-HBV dinucleotide 3′-dA-U2′OMe have…”
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Pope John Paul II and the dignity of the human being by Coughlin, John J

“…The belief that each human being possesses a metaphysical value simply in the fact of his or her existence remains at the root of Pope John Paul II's…”
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Asymptotic and Non-Asymptotic Model Reduction for Kinetic Descriptions of Plasma by Coughlin, John B

“…Plasma dynamics are coupled across microscopic and macroscopic scales by a variety of nonlinear mechanisms. These include repartition of energy due to kinetic…”
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RAPID FUNCTIONALIZATION AND LOADING OF SOLID SUPPORTS by Iyer, Radhakrishnan P., Coughlin, John E., Padmanabhan, Seetharamaiyer

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Microwave-assisted functionalization of solid supports for rapid loading of nucleosides by Iyer, Radhakrishnan P, Padmanabhan, Seetharamaiyer, Coughlin, John E

“…Ultra-fast and efficient functionalization of solid supports such as controlled-pore glass (CPG), amino methyl polystyrene, and Tentagel has been achieved…”
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Adam, Will. Legal Flexibility and the Mission of the Church: Dispensation and Economy in Ecclesiastical Law . Surrey: Ashgate, 2011. xix+243 pp. £74.00 by Coughlin, John J.

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A simple enzyme–substrate localized conjugation method to generate immobilized, functional glutathione S-transferase fusion protein columns for affinity enrichment by Coughlin, John, Masci, Allyson, Gronke, Robert S., Bergelson, Svetlana, Co, Carl

“…Immobilized protein receptors and enzymes are tools for isolating or enriching ligands and substrates based on affinity. For example, glutathione S-transferase…”
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Osteopenia in women with hypothalamic amenorrhea: a prospective study by Biller, B M, Coughlin, J F, Saxe, V, Schoenfeld, D, Spratt, D I, Klibanski, A

“…Hypothalamic amenorrhea, a common disorder associated with abnormalities in gonadotropin pulsatility and subsequent estrogen deficiency, is usually transient,…”
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Alternative dispute resolution in electricity: Just do it by Coughlin, John T.

“…Using mediation and arbitration, rather than traditional litigation, would produce enormous savings to the utility industry—in costs, time, and sparing use of…”
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HIGHER PLASMA TRIMETHYLAMINE-N-OXIDE IS ASSOCIATED WITH GREATER ATHEROSCLEROTIC BURDEN QUANTIFIED BY THE SYNTAX SCORE by Senthong, Vichai, Li, Xinmin, Coughlin, John, Hudec, Timothy, Neale, Sarah, Li, Lin, Wu, Yuping, Wang, Zeneng, Hazen, Stanley, Tang, Wai Hong

“…Background: Trimethylamine-N-oxide (TMAO), a gut microbiota metabolite from dietary of phosphatidylcholine, shows a mechanistic link to coronary artery disease…”
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Ministerium Justitiae: Jurisprudence of the Supreme Tribunal of the Apostolic Signatura, Official Latin with English Translation (review) by Coughlin, John J

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Activation of Retinoic Acid Inducible Gene (RIG-I) by Nucleotide Analogs: A Potential Novel Mechanism for Antiviral Discovery by Iyer, Radhakrishnan, Coughlin, John, Padmanabhan, Seetharamaiyer, Korba, Brent, Myong, Sua

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Marriage and Mulieris Dignitatem by Coughlin, John J

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