Search Results - "Coughlin, David"

Progressive supranuclear palsy: Advances in diagnosis and management by Coughlin, David G., Litvan, Irene

“…Progressive supranuclear palsy (PSP) is a complex clinicopathologic disease with no current cure or disease modulating therapies that can only be definitively…”
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Sex Differences for Clinical Correlates of Alzheimer's Pathology in People with Lewy Body Pathology by Bayram, Ece, Coughlin, David G., Litvan, Irene

“…ABSTRACT Background Lewy body (LB) dementias have limited clinical diagnostic accuracy because of frequent copathologies contributing to clinical…”
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Pathological Influences on Clinical Heterogeneity in Lewy Body Diseases by Coughlin, David G., Hurtig, Howard I., Irwin, David J.

“…ABSTRACT PD, PD with dementia, and dementia with Lewy bodies are clinical syndromes characterized by the neuropathological accumulation of alpha‐synuclein in…”
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Sex differences for phenotype in pathologically defined dementia with Lewy bodies by Bayram, Ece, Coughlin, David G, Banks, Sarah J, Litvan, Irene

“…IntroductionSex differences in dementia with Lewy bodies (DLB) have been reported in clinically defined cohorts; however, clinical diagnostic accuracy in DLB…”
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Group swimming behaviour and energetics in bluegill Lepomis macrochirus and rainbow trout Oncorhynchus mykiss by Currier, Megan, Rouse, Jon, Coughlin, David J.

“…Group swimming size influences metabolic energy consumption and swimming behaviour in fishes. Hydrodynamic flows and vortices of other fish are thought to be…”
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Fluid and Biopsy Based Biomarkers in Parkinson's Disease by Coughlin, David G., Irwin, David J.

“…Several advances in fluid and tissue-based biomarkers for use in Parkinson's disease (PD) and other synucleinopathies have been made in the last several years…”
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Nitrous Oxide Toxicity With Subsequent Recovery by DiPane, Joseph, Tiem, Michelle, Wright, Brenton A, Qayoumi, Wali, Coughlin, David G.

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Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders by Coughlin, David, Xie, Sharon X., Liang, Mendy, Williams, Andrew, Peterson, Claire, Weintraub, Daniel, McMillan, Corey T., Wolk, David A., Akhtar, Rizwan S., Hurtig, Howard I., Branch Coslett, H., Hamilton, Roy H., Siderowf, Andrew D., Duda, John E., Rascovsky, Katya, Lee, Edward B., Lee, Virginia M.‐Y., Grossman, Murray, Trojanowski, John Q., Irwin, David J.

“…Objective To use digital histology in a large autopsy cohort of Lewy body disorder (LBD) patients with dementia to test the hypotheses that co‐occurring…”
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Distribution patterns of tau pathology in progressive supranuclear palsy by Kovacs, Gabor G., Lukic, Milica Jecmenica, Irwin, David J., Arzberger, Thomas, Respondek, Gesine, Lee, Edward B., Coughlin, David, Giese, Armin, Grossman, Murray, Kurz, Carolin, McMillan, Corey T., Gelpi, Ellen, Compta, Yaroslau, van Swieten, John C., Laat, Laura Donker, Troakes, Claire, Al-Sarraj, Safa, Robinson, John L., Roeber, Sigrun, Xie, Sharon X., Lee, Virginia M.- Y., Trojanowski, John Q., Höglinger, Günter U.

“…Progressive supranuclear palsy (PSP) is a 4R-tauopathy predominated by subcortical pathology in neurons, astrocytes, and oligodendroglia associated with…”
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Field kinematics of intermittent swimming in bluegill sunfish (Lepomis macrochirus) —pelagic locomotion and littoral maneuverability by Coughlin, David J, Morris, Catherine, Postupaka, Dasha, Gee, Paige, Reynolds, Zoë, Wood, Bradley

“…Abstract Objectives Locomotion is essential for the survival of animals. Fishes have evolved mechanisms to minimize the cost of transport. For example,…”
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Physician‐Assisted Dying: Access and Utilization in Patients with Movement Disorders by Damron, Lisa, Bayram, Ece, McGehrin, Kevin, Reynolds, Jane, Hess, Robert, Coughlin, David G., Litvan, Irene

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α‐Synuclein Seed Amplification in CSF and Brain from Patients with Different Brain Distributions of Pathological α‐Synuclein in the Context of Co‐Pathology and Non‐LBD Diagnoses by Arnold, Moriah R., Coughlin, David G., Brumbach, Barbara H., Smirnov, Denis S., Concha‐Marambio, Luis, Farris, Carly M., Ma, Yihua, Kim, Yongya, Wilson, Edward N., Kaye, Jeffrey A., Hiniker, Annie, Woltjer, Randy L., Galasko, Doug R., Quinn, Joseph F.

“…Objective The purpose of this study was to determine the sensitivity and specificity of α‐synuclein seed amplification assay (αSyn‐SAA) in antemortem and…”
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Progressive Supranuclear Palsy and Corticobasal Degeneration by Coughlin, David G, Dickson, Dennis W, Josephs, Keith A, Litvan, Irene

“…Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are neurodegenerative tauopathies with neuronal and glial lesions composed of tau that…”
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Tau seeds occur before earliest Alzheimer’s changes and are prevalent across neurodegenerative diseases by Manca, Matteo, Standke, Heidi G., Browne, Danielle F., Huntley, Mikayla L., Thomas, Olivia R., Orrú, Christina D., Hughson, Andrew G., Kim, Yongya, Zhang, Jing, Tatsuoka, Curtis, Zhu, Xiongwei, Hiniker, Annie, Coughlin, David G., Galasko, Douglas, Kraus, Allison

“…Tau neurofibrillary tangles are a hallmark of Alzheimer’s disease neuropathological change. However, it remains largely unclear how distinctive Alzheimer’s…”
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Impacts of thermal acclimatization on fish skeletal muscle by Moran, Clinton J., Coughlin, David J., Jebb, Kamryn E., Travitz, Leksi, Gerry, Shannon P.

“…Thermal acclimation allows ectotherms to maintain physiological homeostasis while occupying habitats with constantly changing temperatures. This process is…”
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Sex differences for clinical correlates of substantia nigra neuron loss in people with Lewy body pathology by Bayram, Ece, Coughlin, David G, Rajmohan, Ravi, Litvan, Irene

“…Lewy body dementia (LBD) phenotype is associated with the presence and degree of Lewy body, Alzheimer's pathologies, and substantia nigra neuron loss. Nigral…”
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Emerging Diagnostic and Therapeutic Strategies for Tauopathies by Coughlin, David, Irwin, David J.

“…Purpose of Review Tauopathies represent a spectrum of incurable and progressive age-associated neurodegenerative diseases that currently are diagnosed…”
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Intermittent swimming and muscle power output in brook trout, Salvelinus fontinalis by Coughlin, David J., Dutterer, Madeline D.

“…Slow and sustainable intermittent swimming has recently been described in several Centrarchid fishes, such as bluegill and largemouth bass. This swimming…”
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Hippocampal subfield pathologic Burden in Lewy body diseases versus Alzheimer’s disease by Coughlin, David G., Grossman, Murray, Trojanowski, John Q., Irwin, David J.

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Thermal acclimation leads to variable muscle responses in two temperate labrid fishes by Moran, Clinton J, Jebb, Kamryn E, Travitz, Leksi, Coughlin, David J, Gerry, Shannon P

“…Temperature can be a key abiotic factor in fish distribution, as it affects most physiological processes. Specifically, temperature can affect locomotor…”
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