Search Results - "Coughlan, Christina M."

The burden of trisomy 21 disrupts the proteostasis network in Down syndrome by Aivazidis, Stefanos, Coughlan, Christina M, Rauniyar, Abhishek K, Jiang, Hua, Liggett, L Alexander, Maclean, Kenneth N, Roede, James R

“…Down syndrome (DS) is a genetic disorder caused by trisomy of chromosome 21. Abnormalities in chromosome number have the potential to lead to disruption of the…”
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Safety and efficacy of sargramostim (GM‐CSF) in the treatment of Alzheimer's disease by Potter, Huntington, Woodcock, Jonathan H., Boyd, Timothy D., Coughlan, Christina M., O'Shaughnessy, John R., Borges, Manuel T., Thaker, Ashesh A., Raj, Balaibail A., Adamszuk, Katarzyna, Scott, David, Adame, Vanesa, Anton, Paige, Chial, Heidi J., Gray, Helen, Daniels, Joseph, Stocker, Michelle E., Sillau, Stefan H.

“…Introduction Inflammatory markers have long been observed in the brain, cerebrospinal fluid (CSF), and plasma of Alzheimer's disease (AD) patients, suggesting…”
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Mitotic defects lead to neuronal aneuploidy and apoptosis in frontotemporal lobar degeneration caused by MAPT mutations by Caneus, Julbert, Granic, Antoneta, Rademakers, Rosa, Dickson, Dennis W, Coughlan, Christina M, Chial, Heidi J, Potter, Huntington

“…Mutant Tau (MAPT) can lead to frontotemporal lobar degeneration (FTLD). Previous studies associated MAPT mutations and altered function with aneuploidy and…”
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Rapid Activation of Neuroinflammation in Stroke: Plasma and Extracellular Vesicles Obtained on a Mobile Stroke Unit by Kowalski, Robert G., Ledreux, Aurélie, Violette, John E., Neumann, Robert T., Ornelas, David, Yu, Xiaoli, Griffiths, Steven G., Lewis, Scott, Nash, Priscilla, Monte, Andrew A., Coughlan, Christina M., Deighan, Clayton, Grotta, James C., Jones, William J., Graner, Michael W.

“…Neuroinflammation is ubiquitous in acute stroke and worsens outcome. However, the precise timing of the inflammatory response is unknown, hindering the design…”
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Varicella-Zoster Virus Infection of Primary Human Spinal Astrocytes Produces Intracellular Amylin, Amyloid-β, and an Amyloidogenic Extracellular Environment by Bubak, Andrew N, Como, Christina N, Coughlan, Christina M, Johnson, Noah R, Hassell, James E, Mescher, Teresa, Niemeyer, Christy S, Mahalingam, Ravi, Cohrs, Randall J, Boyd, Timothy D, Potter, Huntington, Russ, Holger A, Nagel, Maria A

“…Abstract Background Herpes zoster is linked to amyloid-associated diseases, including dementia, macular degeneration, and diabetes mellitus, in epidemiological…”
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Degradation of Mutated Bovine Pancreatic Trypsin Inhibitor in the Yeast Vacuole Suggests Post-endoplasmic Reticulum Protein Quality Control by Coughlan, Christina M., Walker, Jennifer L., Cochran, Jared C., Wittrup, K. Dane, Brodsky, Jeffrey L.

“…The rate-limiting step in protein secretion is folding, which occurs in the endoplasmic reticulum (ER) lumen, and almost all secreted proteins contain…”
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Amylin, Aβ42, and Amyloid in Varicella Zoster Virus Vasculopathy Cerebrospinal Fluid and Infected Vascular Cells by Bubak, Andrew N, Beseler, Cheryl, Como, Christina N, Coughlan, Christina M, Johnson, Noah R, Hassell, James E, Burnet, Anna M, Mescher, Teresa, Schmid, D Scott, Coleman, Colin, Mahalingam, Ravi, Cohrs, Randall J, Boyd, Timothy D, Potter, Huntington, Shilleh, Ali H, Russ, Holger A, Nagel, Maria A

“…Abstract Background Varicella zoster virus (VZV) vasculopathy is characterized by persistent arterial inflammation leading to stroke. Studies show that VZV…”
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Proteasome activity modulates amyloid toxicity by Galvin, John, Curran, Elizabeth, Arteaga, Francisco, Goossens, Alicia, Aubuchon-Endsley, Nicki, McMurray, Michael A, Moore, Jeffrey, Hansen, Kirk C, Chial, Heidi J, Potter, Huntington, Brodsky, Jeffrey L, Coughlan, Christina M

“…Abstract Alzheimer's disease (AD) is responsible for 60%–80% of identified cases of dementia. While the generation and accumulation of amyloid precursor…”
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Granulocyte‐macrophage colony‐stimulating factor reverses Alzheimer’s disease pathology in the tgf344‐AD rat model by Ahmed, Md. Mahiuddin, Wang, Athena Ching‐Jung, Boyd, Timothy D., Solano, D. Adriana, Vielle, Anne, Markham, Neil, Coughlan, Christina M, Chial, Heidi J, Vergara, M. Natalia, Potter, Huntington

“…Background Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), a hematopoietic growth factor, has shown therapeutic and neuroprotective effects in…”
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Use of yeast as a model system to investigate protein conformational diseases by COUGHLAN, Christina M, BRODSKY, Jeffrey L

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Proteomic analysis of the amyloid precursor protein fragment C99: expression in yeast by Sparvero, Louis J., Patz, Sarah, Brodsky, Jeffrey L., Coughlan, Christina M.

“…The accumulation and aggregation of fragments of amyloid precursor protein (APP) are central to the development of Alzheimer’s disease. The production of the…”
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Yeast as a model system to investigate protein conformational diseases by Coughlan, Christina M, Brodsky, Jeffrey L

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Rapid Activation of Neuroinflammation in Stroke: Plasma and Extracellular Vesicles Obtained on a Mobile Stroke Unit by Kowalski, Robert G., Ledreux, Aurélie, Violette, John E., Neumann, Robert T., Ornelas, David, Yu, Xiaoli, Griffiths, Steven G., Lewis, Scott, Nash, Priscilla, Monte, Andrew A., Coughlan, Christina M., Deighan, Clayton, Grotta, James C., Jones, William J., Graner, Michael W.

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Abstract 17: Ultra-early Activation Of Neuroinflammatory Cascade Following Acute Stroke: Plasma And Extracellular Vesicle Biomarkers From A Mobile Stroke Unit by Kowalski, Robert, Ledreux, Aurelie, Violette, John E, Neumann, Robert T, Grotta, James C, Ornelas, David, Yu, Xiaoli, Griffiths, Steven G, Lewis, Scott, Nash, Priscilla, Monte, Andrew A, Coughlan, Christina M, Deighan, Clayton, Jones, William J, Graner, Michael W

“…BackgroundNeuroinflammation is ubiquitous in acute stroke and worsens outcome. However, the precise timing of the inflammatory response is unknown, hindering…”
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Increased Plasma brain‐derived neurotrophic factor (BDNF) as a Biomarker for Differentiating Mild Cognitive Impairment from Cognitive Healthy: A case‐control study by Ng, Ted Kheng Siang, Coughlan, Christina M, Heyn, Patricia C, Tagawa, Alex, Carollo, James, Kua, Ee‐Heok, Mahendran, Rathi

“…Background Across the spectrum of Alzheimer’s disease (AD), we previously conducted a meta‐analysis and concluded significantly decreased brain‐derived…”
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Granulocyte‐Macrophage Colony‐Stimulating Factor Reduces Two Major Pathological Hallmarks of Alzheimer’s Disease and Astrogliosis in the TgF344‐AD Rat Model by Ahmed, Md. Mahiuddin, Wang, Athena Ching‐Jung, Boyd, Timothy D., Solano, D. Adriana, Vielle, Anne, Markham, Neil, Coughlan, Christina M, Chial, Heidi J, Vergara, M. Natalia, Potter, Huntington

“…Background Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), a hematopoietic growth factor and the innate immune system modulator, has shown…”
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The immune cytokine granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) is an effective treatment for both Alzheimer’s disease and the viral diseases caused by West Nile Virus and SARS‐CoV‐2 infection, indicating that inflammation and viral infection may be partners and therapeutic co‐targets in many brain disorders by Potter, Huntington, Boyd, Timothy D., Woodcock, Jonathan H, Sillau, Stefan H, Ahmed, Md. Mahiuddin, Wang, Athena Ching‐Jung, Chial, Heidi J, Coughlan, Christina M, Kendall, Lon V., Bosco‐Lauth, Angela, Markham, Neil, Stonedahl, Sarah, Fong, Derek, Clarke, Penny, Tyler, Kenneth L.

“…Background GM‐CSF has been considered a potential therapeutic target in many disorders associated with inflammation because it is upregulated and upregulates…”
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Inflammation and innate immune system activation in neurodegeneration, Down syndrome, aging, and infection: Therapeutic target or partner? by Potter, Huntington, Boyd, Timothy D., Ahmed, Md. Mahiuddin, Kendall, Lon V., Sillau, Stefan H, Coughlan, Christina M, Clarke, Penny, Stonedahl, Sarah, Chial, Heidi J

“…Background Characteristic features/biomarkers of innate immune system activation and inflammation are associated with neurodegenerative diseases (e.g.,…”
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Small molecule inhibitors of apolipoprotein E4‐catalyzed amyloid‐β fibrillization as novel therapeutics for Alzheimer’s disease: Development of new models and analysis methods/screening studies/platforms by Johnson, Noah R., Wang, Athena Ching‐Jung, Coughlan, Christina M., Lucero, Esteban M., Viltz, Lisa, Allen, Cody, Markham, Neil, Chial, Heidi J., Potter, Huntington

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Small molecule inhibitors of apolipoprotein E4‐catalyzed amyloid‐β fibrillization as novel therapeutics for Alzheimer’s disease by Johnson, Noah R., Wang, Athena Ching‐Jung, Coughlan, Christina M., Lucero, Esteban M., Viltz, Lisa, Allen, Cody, Markham, Neil, Chial, Heidi J., Potter, Huntington

“…Background Alzheimer’s disease (AD) is a progressive neurodegenerative illness initiated by fibrillization of the amyloid‐beta (Aβ) peptide in the brain…”
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