Search Results - "Coughlan, Aisling"

Exploiting epigenetic dependencies in ovarian cancer therapy by Coughlan, Aisling Y., Testa, Giuseppe

“…Ovarian cancer therapy has remained fundamentally unchanged for 50 years, with surgery and chemotherapy still the frontline treatments. Typically asymptomatic…”
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Population genomics shows no distinction between pathogenic Candida krusei and environmental Pichia kudriavzevii: One species, four names by Douglass, Alexander P, Offei, Benjamin, Braun-Galleani, Stephanie, Coughlan, Aisling Y, Martos, Alexandre A R, Ortiz-Merino, Raúl A, Byrne, Kevin P, Wolfe, Kenneth H

“…We investigated genomic diversity of a yeast species that is both an opportunistic pathogen and an important industrial yeast. Under the name Candida krusei,…”
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Polymorphic centromere locations in the pathogenic yeast Candida parapsilosis by Ola, Mihaela, O'Brien, Caoimhe E, Coughlan, Aisling Y, Ma, Qinxi, Donovan, Paul D, Wolfe, Kenneth H, Butler, Geraldine

“…Centromeres pose an evolutionary paradox: strongly conserved in function but rapidly changing in sequence and structure. However, in the absence of damage,…”
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TPP riboswitch-dependent regulation of an ancient thiamin transporter in Candida by Donovan, Paul D, Holland, Linda M, Lombardi, Lisa, Coughlan, Aisling Y, Higgins, Desmond G, Wolfe, Kenneth H, Butler, Geraldine

“…Riboswitches are non-coding RNA molecules that regulate gene expression by binding to specific ligands. They are primarily found in bacteria. However, one…”
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WHO elements – A new category of selfish genetic elements at the borderline between homing elements and transposable elements by Osborne, Matthieu, Fubara, Athaliah, Ó Cinnéide, Eoin, Coughlan, Aisling Y., Wolfe, Kenneth H.

“…Homing genetic elements are a form of selfish DNA that inserts into a specific target site in the genome and spreads through the population by a process of…”
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Evolutionary instability of CUG-Leu in the genetic code of budding yeasts by Krassowski, Tadeusz, Coughlan, Aisling Y., Shen, Xing-Xing, Zhou, Xiaofan, Kominek, Jacek, Opulente, Dana A., Riley, Robert, Grigoriev, Igor V., Maheshwari, Nikunj, Shields, Denis C., Kurtzman, Cletus P., Hittinger, Chris Todd, Rokas, Antonis, Wolfe, Kenneth H.

“…The genetic code used in nuclear genes is almost universal, but here we report that it changed three times in parallel during the evolution of budding yeasts…”
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Giant GAL gene clusters for the melibiose‐galactose pathway in Torulaspora by Venkatesh, Anjan, Murray, Anthony L., Coughlan, Aisling Y., Wolfe, Kenneth H.

“…In many yeast species, the three genes at the centre of the galactose catabolism pathway, GAL1, GAL10 and GAL7, are neighbours in the genome and form a…”
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The reported point centromeres of Scheffersomyces stipitis are retrotransposon long terminal repeats by Coughlan, Aisling Y., Wolfe, Kenneth H.

“…Point centromeres, found in some ascomycete yeasts such Saccharomyces cerevisiae, are very different in structure from the centromeres of other eukaryotes…”
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The yeast mating-type switching endonuclease HO is a domesticated member of an unorthodox homing genetic element family by Coughlan, Aisling Y, Lombardi, Lisa, Braun-Galleani, Stephanie, Martos, Alexandre Ar, Galeote, Virginie, Bigey, Frédéric, Dequin, Sylvie, Byrne, Kevin P, Wolfe, Kenneth H

“…The mating-type switching endonuclease HO plays a central role in the natural life cycle of , but its evolutionary origin is unknown. is a recent addition to…”
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Genomic diversity and meiotic recombination among isolates of the biotech yeast Komagataella phaffii (Pichia pastoris) by Braun-Galleani, Stephanie, Dias, Julie A, Coughlan, Aisling Y, Ryan, Adam P, Byrne, Kevin P, Wolfe, Kenneth H

“…Komagataella phaffii is a yeast widely used in the pharmaceutical and biotechnology industries, and is one of the two species that were previously called…”
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Steroid-free combination of 5-azacytidine and venetoclax for the treatment of multiple myeloma by Flanagan, Lyndsey, Coughlan, Aisling, Cosgrove, Nicola, Roe, Andrew, Wang, Yu, Gilmore, Stephanie, Drozdz, Izabela, Comerford, Claire, Ryan, Jeremy, Minihane, Emma, Parvin, Salma, O'Dwyer, Michael, Quinn, John, Murphy, Philip, Furney, Simon, Glavey, Siobhan, Chonghaile, Tríona Ní, Foundation, Leukemia Research, Ireland, Science Foundation, Research, Breakthrough Cancer

“…Multiple myeloma (MM) is an incurable plasma cell malignancy that, despite an unprecedented increase in overall survival, lacks truly risk-adapted or targeted…”
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Coverage-Versus-Length Plots, a Simple Quality Control Step for de Novo Yeast Genome Sequence Assemblies by Douglass, Alexander P, O'Brien, Caoimhe E, Offei, Benjamin, Coughlan, Aisling Y, Ortiz-Merino, Raúl A, Butler, Geraldine, Byrne, Kevin P, Wolfe, Kenneth H

“…Illumina sequencing has revolutionized yeast genomics, with prices for commercial draft genome sequencing now below $200. The popular SPAdes assembler makes it…”
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Ploidy Variation in Kluyveromyces marxianus Separates Dairy and Non-dairy Isolates by Ortiz-Merino, Raúl A, Varela, Javier A, Coughlan, Aisling Y, Hoshida, Hisashi, da Silveira, Wendel B, Wilde, Caroline, Kuijpers, Niels G A, Geertman, Jan-Maarten, Wolfe, Kenneth H, Morrissey, John P

“…is traditionally associated with fermented dairy products, but can also be isolated from diverse non-dairy environments. Because of thermotolerance, rapid…”
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Centromeres of the Yeast Komagataella phaffii (Pichia pastoris) Have a Simple Inverted-Repeat Structure by Coughlan, Aisling Y, Hanson, Sara J, Byrne, Kevin P, Wolfe, Kenneth H

“…Centromere organization has evolved dramatically in one clade of fungi, the Saccharomycotina. These yeasts have lost the ability to make normal eukaryotic…”
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The Transcriptional Regulator Prdm1 Is Essential for the Early Development of the Sensory Whisker Follicle and Is Linked to the Beta-Catenin First Dermal Signal by Manti, Pierluigi G, Darbellay, Fabrice, Leleu, Marion, Coughlan, Aisling Y, Moret, Bernard, Cuennet, Julien, Droux, Frederic, Stoudmann, Magali, Mancini, Gian-Filippo, Hautier, Agnès, Sordet-Dessimoz, Jessica, Vincent, Stephane D, Testa, Giuseppe, Cossu, Giulio, Barrandon, Yann

“…mutant mice are one of the rare mutant strains that do not develop whisker hair follicles while still displaying a pelage. Here, we show that is expressed at…”
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Preliminary investigation of the dissolution behavior, cytocompatibility, effects of fibrinogen conformation and platelet adhesion for radiopaque embolic particles by Kehoe, Sharon, Tremblay, Marie-Laurence, Coughlan, Aisling, Towler, Mark R, Rainey, Jan K, Abraham, Robert J, Boyd, Daniel

“…Experimental embolic particles based on a novel zinc-silicate glass system have been biologically evaluated for potential consideration in transcatheter…”
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Comparative genomics of biotechnologically important yeasts by Riley, Robert, Haridas, Sajeet, Wolfe, Kenneth H., Lopes, Mariana R., Hittinger, Chris Todd, Göker, Markus, Salamov, Asaf A., Wisecaver, Jennifer H., Long, Tanya M., Calvey, Christopher H., Aerts, Andrea L., Barry, Kerrie W., Choi, Cindy, Clum, Alicia, Coughlan, Aisling Y., Deshpande, Shweta, Douglass, Alexander P., Hanson, Sara J., Klenk, Hans-Peter, LaButti, Kurt M., Lapidus, Alla, Lindquist, Erika A., Lipzen, Anna M., Meier-Kolthoff, Jan P., Ohm, Robin A., Otillar, Robert P., Pangilinan, Jasmyn L., Peng, Yi, Rokas, Antonis, Rosa, Carlos A., Scheuner, Carmen, Sibirny, Andriy A., Slot, Jason C., Stielow, J. Benjamin, Sun, Hui, Kurtzman, Cletus P., Blackwell, Meredith, Grigoriev, Igor V., Jeffries, Thomas W.

“…Ascomycete yeasts are metabolically diverse, with great potential for biotechnology. Here, we report the comparative genome analysis of 29 taxonomically and…”
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Synthesis, Processing and the Effect of Thermal Treatment on the Solubility, Antioxidant Potential and Cytocompatibility of Y2O3 and CeO2 doped SiO2-SrO-Na2O Glass-Ceramics by Placek, Lana M, Keenan, Timothy J, coughlan, Aisling, Wren, Anthony W

“…Thermal treatment of a 0.52SiO2-0.24SrO-0.24-xNa2O-xMO glass-ceramic series (where x = 0.08 and MO = Y2O3 or CeO2) was conducted in order to synthesize yttrium…”
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The reported point centromeres of Scheffersomyces stipitis are retrotransposon LTRs by Coughlan, Aisling Y, Wolfe, Kenneth H

“…Point centromeres, found in some ascomycete yeasts such Saccharomyces cerevisiae, are very different in structure from the centromeres of other eukaryotes…”
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Fill volume as an indicator of surface heterogeneity in glass vials for parenteral packaging by Kucko, Nathan W, Keenan, Tim, Coughlan, Aisling, Hall, Matthew M

“…The chemical durability of glass vials for parenteral packaging is typically assessed by completely filling the vial with a medium of interest. This testing…”
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