Search Results - "Coufal, Nicole"

Primary Cilia in the Developing and Mature Brain by Guemez-Gamboa, Alicia, Coufal, Nicole G., Gleeson, Joseph G.

“…Primary cilia were the largely neglected nonmotile counterparts of their better-known cousin, the motile cilia. For years these nonmotile cilia were considered…”
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Nicole G. Coufal by Coufal, Nicole G.

“…Physician-scientist Nicole Coufal cares for critically ill children in the pediatric ICU and studies microglial contributions to neurodevelopmental and…”
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An environment-dependent transcriptional network specifies human microglia identity by Gosselin, David, Skola, Dylan, Coufal, Nicole G., Holtman, Inge R., Schlachetzki, Johannes C. M., Sajti, Eniko, Jaeger, Baptiste N., O’Connor, Carolyn, Fitzpatrick, Conor, Pasillas, Martina P., Pena, Monique, Adair, Amy, Gonda, David D., Levy, Michael L., Ransohoff, Richard M., Gage, Fred H., Glass, Christopher K.

“…Microglia play essential roles in central nervous system (CNS) homeostasis and influence diverse aspects of neuronal function. However, the transcriptional…”
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Brain cell type-specific enhancer-promoter interactome maps and disease - risk association by Nott, Alexi, Holtman, Inge R, Coufal, Nicole G, Schlachetzki, Johannes C M, Yu, Miao, Hu, Rong, Han, Claudia Z, Pena, Monique, Xiao, Jiayang, Wu, Yin, Keulen, Zahara, Pasillas, Martina P, O'Connor, Carolyn, Nickl, Christian K, Schafer, Simon T, Shen, Zeyang, Rissman, Robert A, Brewer, James B, Gosselin, David, Gonda, David D, Levy, Michael L, Rosenfeld, Michael G, McVicker, Graham, Gage, Fred H, Ren, Bing, Glass, Christopher K

“…Noncoding genetic variation is a major driver of phenotypic diversity, but functional interpretation is challenging. To better understand common genetic…”
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Emerging Role of Plasma Microbial Cell-free DNA in the Diagnosis of Pediatric Mucormycosis by Gracia, Michael, Hadley, Emma, Ramchandar, Nanda, Coufal, Nicole G

“…Mucormycosis is a rare and devastating angioinvasive infection that can be challenging to diagnose due to the low sensitivity of current noninvasive…”
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L1 retrotransposition in neurons is modulated by MeCP2 by Muotri, Alysson R, Gage, Fred H, Marchetto, Maria C. N, Coufal, Nicole G, Oefner, Ruth, Yeo, Gene, Nakashima, Kinichi

“…Long interspersed nuclear elements-1 (LINE-1 or L1s) are abundant retrotransposons that comprise approximately 20% of mammalian genomes. Active L1…”
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Application of cell-free plasma next-generation sequencing technology in the diagnosis and management of pediatric meningitis by Duster, Nicole, Ramchandar, Nanda, Foley, Jennifer, Farnaes, Lauge, Coufal, Nicole G.

“…This retrospective study evaluates the clinical utility of CFPNGS in the diagnosis and management of pediatric meningitis. CFPNGS identified a causative…”
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Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo by Hasselmann, Jonathan, Coburn, Morgan A., England, Whitney, Figueroa Velez, Dario X., Kiani Shabestari, Sepideh, Tu, Christina H., McQuade, Amanda, Kolahdouzan, Mahshad, Echeverria, Karla, Claes, Christel, Nakayama, Taylor, Azevedo, Ricardo, Coufal, Nicole G., Han, Claudia Z., Cummings, Brian J., Davtyan, Hayk, Glass, Christopher K., Healy, Luke M., Gandhi, Sunil P., Spitale, Robert C., Blurton-Jones, Mathew

“…iPSC-derived microglia offer a powerful tool to study microglial homeostasis and disease-associated inflammatory responses. Yet, microglia are highly sensitive…”
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Increased Peripheral Blood Neutrophil Activation Phenotypes and Neutrophil Extracellular Trap Formation in Critically Ill Coronavirus Disease 2019 (COVID-19) Patients: A Case Series and Review of the Literature by Masso-Silva, Jorge A, Moshensky, Alexander, Lam, Michael T Y, Odish, Mazen F, Patel, Arjun, Xu, Le, Hansen, Emily, Trescott, Samantha, Nguyen, Celina, Kim, Roy, Perofsky, Katherine, Perera, Samantha, Ma, Lauren, Pham, Josephine, Rolfsen, Mark, Olay, Jarod, Shin, John, Dan, Jennifer M, Abbott, Robert K, Ramirez, Sydney, Alexander, Thomas H, Lin, Grace Y, Fuentes, Ana Lucia, Advani, Ira, Gunge, Deepti, Pretorius, Victor, Malhotra, Atul, Sun, Xin, Duran, Jason, Hepokoski, Mark, Crotty, Shane, Coufal, Nicole G, Meier, Angela, Crotty Alexander, Laura E

“…Abstract Background Increased inflammation has been well defined in coronavirus disease 2019 (COVID-19), while definitive pathways driving severe forms of this…”
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Vaccine Strain Varicella Infection in an Infant With Previously Undiagnosed Perinatal Human Immunodeficiency Type-1 Infection by Farnaes, Lauge, Coufal, Nicole G, Spector, Stephen A

“…A 15-month-old infant with a history of developmental delay and weight loss with multiple hospital admissions was diagnosed with a pustular lesion identified…”
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CLP1 Founder Mutation Links tRNA Splicing and Maturation to Cerebellar Development and Neurodegeneration by Schaffer, Ashleigh E., Eggens, Veerle R.C., Caglayan, Ahmet Okay, Reuter, Miriam S., Scott, Eric, Coufal, Nicole G., Silhavy, Jennifer L., Xue, Yuanchao, Kayserili, Hulya, Yasuno, Katsuhito, Rosti, Rasim Ozgur, Abdellateef, Mostafa, Caglar, Caner, Kasher, Paul R., Cazemier, J. Leonie, Weterman, Marian A., Cantagrel, Vincent, Cai, Na, Zweier, Christiane, Altunoglu, Umut, Satkin, N. Bilge, Aktar, Fesih, Tuysuz, Beyhan, Yalcinkaya, Cengiz, Caksen, Huseyin, Bilguvar, Kaya, Fu, Xiang-Dong, Trotta, Christopher R., Gabriel, Stacey, Reis, André, Gunel, Murat, Baas, Frank, Gleeson, Joseph G.

“…Neurodegenerative diseases can occur so early as to affect neurodevelopment. From a cohort of more than 2,000 consanguineous families with childhood…”
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An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells by Yeo, Gene W, Fu, Xiang-Dong, Gage, Fred H, Coufal, Nicole G, Liang, Tiffany Y, Peng, Grace E

“…Using CLIP-seq technology, the genome-wide binding sites of the FOX2 splicing regulator in human embryonic stem cells (hESCs) are now identified. Further work…”
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Use of Plasma Metagenomic Next-generation Sequencing for Pathogen Identification in Pediatric Endocarditis by To, Rachel K., Ramchandar, Nanda, Gupta, Aamisha, Pong, Alice, Cannavino, Christopher, Foley, Jennifer, Farnaes, Lauge, Coufal, Nicole G.

“…Pediatric infective endocarditis incurs significant morbidity and generally occurs among children with underlying heart disease. Identification of a pathogen…”
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L1 retrotransposition in human neural progenitor cells by Coufal, Nicole G., Garcia-Perez, José L., Peng, Grace E., Yeo, Gene W., Mu, Yangling, Lovci, Michael T., Morell, Maria, O’Shea, K. Sue, Moran, John V., Gage, Fred H.

“…Shaping the individual brain It is known that LINE-1 (long interspersed element-1) retrotransposons can move throughout the genomes of adult rat neural…”
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Human microglial models to study host–virus interactions by McMillan, Rachel E., Wang, Ellen, Carlin, Aaron F., Coufal, Nicole G.

“…Microglia, the resident macrophage of the central nervous system, are increasingly recognized as contributing to diverse aspects of human development, health,…”
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Rocky Mountain Spotted Fever in Children along the US‒Mexico Border, 2017-2023 by Chiang, Leslie, Ramchandar, Nanda, Aramkul, Jacquelyn, Fireizen, Yaron, Beatty, Mark E, Monroe, Madeleine, Shah, Seema, Foley, Jennifer, Coufal, Nicole G

“…Rocky mountain spotted fever (RMSF) causes significant illness and death in children. Although historically rare in California, USA, RMSF is endemic in areas…”
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Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK by Li, Yajuan, Munoz-Mayorga, Daniel, Nie, Yuhang, Kang, Ningxin, Tao, Yuren, Lagerwall, Jessica, Pernaci, Carla, Curtin, Genevieve, Coufal, Nicole G, Mertens, Jerome, Shi, Lingyan, Chen, Xu

“…The accumulation of lipid droplets (LDs) in aging and Alzheimer's disease brains is considered a pathological phenomenon with unresolved cellular and molecular…”
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Community-acquired pneumonia in children: cell-free plasma sequencing for diagnosis and management by Farnaes, Lauge, Wilke, Julianne, Ryan Loker, Kathleen, Bradley, John S., Cannavino, Christopher R., Hong, David K., Pong, Alice, Foley, Jennifer, Coufal, Nicole G.

“…Community-acquired pneumonia (CAP) is a common cause of pediatric hospital admission. Empiric antibiotic therapy for hospitalized children with serious CAP now…”
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The prototypical interferonopathy: Aicardi‐Goutières syndrome from bedside to bench by Hofer, Markus J., Modesti, Nicholson, Coufal, Nicole G., Wang, Qingde, Sase, Sunetra, Miner, Jonathan J., Vanderver, Adeline, Bennett, Mariko L.

“…Summary Aicardi‐Goutières syndrome (AGS) is a progressive genetic encephalopathy caused by pathogenic mutations in genes controlling cellular anti‐viral…”
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Predictors of successful discontinuation of continuous kidney replacement therapy in a pediatric cohort by Wei, Elizabeth Y., Vuong, Kim T., Lee, Euyhyun, Liu, Lin, Ingulli, Elizabeth, Coufal, Nicole G.

“…Background Recognizing the optimal time to discontinue continuous kidney replacement therapy (CKRT) is necessary to advance patient recovery and mitigate…”
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