Search Results - "Couch, F. J"

PREDICT Plus: development and validation of a prognostic model for early breast cancer that includes HER2 by Wishart, G C, Bajdik, C D, Dicks, E, Provenzano, E, Schmidt, M K, Sherman, M, Greenberg, D C, Green, A R, Gelmon, K A, Kosma, V-M, Olson, J E, Beckmann, M W, Winqvist, R, Cross, S S, Severi, G, Huntsman, D, Pylkäs, K, Ellis, I, Nielsen, T O, Giles, G, Blomqvist, C, Fasching, P A, Couch, F J, Rakha, E, Foulkes, W D, Blows, F M, Bégin, L R, van't Veer, L J, Southey, M, Nevanlinna, H, Mannermaa, A, Cox, A, Cheang, M, Baglietto, L, Caldas, C, Garcia-Closas, M, Pharoah, P D P

“…Background: Predict ( www.predict.nhs.uk ) is an online, breast cancer prognostication and treatment benefit tool. The aim of this study was to incorporate the…”
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Mutant K-Ras increases GSK-3β gene expression via an ETS-p300 transcriptional complex in pancreatic cancer by Zhang, J-S, Koenig, A, Harrison, A, Ugolkov, A V, Fernandez-Zapico, M E, Couch, F J, Billadeau, D D

“…Glycogen synthase kinase-3 beta (GSK-3β) is overexpressed in a number of human malignancies and has been shown to contribute to tumor cell proliferation and…”
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Efficacy of Bilateral Prophylactic Mastectomy in BRCA1 and BRCA2 Gene Mutation Carriers by Hartmann, Lynn C., Sellers, Thomas A., Schaid, Daniel J., Frank, Thomas S., Soderberg, Cheryl L., Sitta, Diana L., Frost, Marlene H., Grant, Clive S., Donohue, John H., Woods, John E., McDonnell, Shannon K., Vockley, Catherine Walsh, Deffenbaugh, Amie, Couch, Fergus J., Jenkins, Robert B.

“…Background: In women with a family history of breast cancer, bilateral prophylactic mastectomy is associated with a decreased risk of subsequent breast cancer…”
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Genetic counselors' practices and confidence regarding variant of uncertain significance results and reclassification from BRCA testing by Scherr, C.L., Lindor, N.M., Malo, T.L., Couch, F.J., Vadaparampil, S.T.

“…Studies indicate variant of uncertain significance (VUS) results are challenging for genetic counselors and patients, often resulting in negative patient…”
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Association of Childhood and Adolescent Anthropometric Factors, Physical Activity, and Diet with Adult Mammographic Breast Density by Sellers, TA, Vachon, CM, Pankratz, VS, Janney, CA, Fredericksen, Z, Brandt, KR, Huang, Y, Couch, FJ, Kushi, LH, Cerhan, JR

“…Early-life exposures may influence the development of breast cancer. The authors examined the association of childhood and adolescent anthropometric factors,…”
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Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis by Cunningham, J M, Vierkant, R A, Sellers, T A, Phelan, C, Rider, D N, Liebow, M, Schildkraut, J, Berchuck, A, Couch, F J, Wang, X, Fridley, B L, Gentry-Maharaj, A, Menon, U, Hogdall, E, Kjaer, S, Whittemore, A, DiCioccio, R, Song, H, Gayther, S A, Ramus, S J, Pharaoh, P D P, Goode, E L

“…Background: Dysregulation of the cell cycle is a hallmark of many cancers including ovarian cancer, a leading cause of gynaecologic cancer mortality worldwide…”
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Variation in genes required for normal mitosis and risk of breast cancer by Olson, J. E, Wang, X, Goode, E. L, Pankratz, V. S, Fredericksen, Z. S, Vierkant, R. A, Pharoah, P. D. P, Cerhan, J. R, Couch, F. J

“…The down-regulation of genes involved in normal cell division can cause aberrant mitoses and increased cell death. Surviving cells exhibit aneuploidy and/or…”
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BRCA1 Mutations in Women Attending Clinics That Evaluate the Risk of Breast Cancer by Couch, Fergus J, DeShano, Michelle L, Blackwood, M. Anne, Calzone, Kathleen, Stopfer, Jill, Campeau, Lisa, Ganguly, Arupa, Rebbeck, Timothy, Weber, Barbara L, Jablon, Lisa, Cobleigh, Melody A, Hoskins, Kent, Garber, Judy E

“…Family history is a significant risk factor for the development of breast cancer. The relative lifetime risk of breast cancer ranges from 1.4 for a woman whose…”
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BRCA1 and BRCA2 genetic testing—pitfalls and recommendations for managing variants of uncertain clinical significance by Eccles, D.M., Mitchell, G., Monteiro, A.N.A., Schmutzler, R., Couch, F.J., Spurdle, A.B., Gómez-García, E.B., Driessen, R., Lindor, N.M., Blok, M.J., Moller, P., de la Hoya, M., Pal, T., Domchek, S., Nathanson, K., Van Asperen, C., Diez, O., Rheim, K., Stoppa-Lyonnet, D., Parsons, M., Goldgar, D.

“…Increasing use of BRCA1/2 testing for tailoring cancer treatment and extension of testing to tumour tissue for somatic mutation is moving BRCA1/2 mutation…”
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CBP truncating mutations in ovarian cancer by Ward, R, Johnson, M, Shridhar, V, van Deursen, J, Couch, F J

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Mutations in the ryanodine receptor gene in central core disease and malignant hyperthermia by Quane, K. A, Healy, J.M.S, Keating, K. E, Manning, B. M, Couch, F. J, Palmucci, L. M, Doriguzzi, C, Fagerlund, T. H, Berg, K, Ording, H, Bendixen, D, Mortier, W, Linz, U, Muller, C. R, McCarthy, T. V

“…Central core disease (CCD) of muscle is an inherited myopathy which is closely associated with malignant hyperthermia (MH) in humans. CCD has recently been…”
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Genetic, functional, and histopathological evaluation of two C-terminal BRCA1 missense variants by Lovelock, P K, Healey, S, Au, W, Sum, E Y M, Tesoriero, A, Wong, E M, Hinson, S, Brinkworth, R, Bekessy, A, Diez, O, Izatt, L, Solomon, E, Jenkins, M, Renard, H, Hopper, J, Waring, P, Tavtigian, S V, Goldgar, D, Lindeman, G J, Visvader, J E, Couch, F J, Henderson, B R, Southey, M, Chenevix-Trench, G, Spurdle, A B, Brown, M A

“…Background: The vast majority of BRCA1 missense sequence variants remain uncharacterised for their possible effect on protein expression and function, and…”
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Centrosome-related genes, genetic variation, and risk of breast cancer by Olson, J. E, Wang, X, Pankratz, V. S, Fredericksen, Z. S, Vachon, C. M, Vierkant, R. A, Cerhan, J. R, Couch, F. J

“…Centrosome amplification has been detected in premalignant lesions and in situ tumors in the breast and in over 70% of invasive breast tumors, and has been…”
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BRCA2 germline mutations in male breast cancer cases and breast cancer families by Couch, Fergus J, Farid, Linda M, DeShano, Michelle L, Tavtigian, Sean V, Calzone, Kathleen, Campeau, Lisa, Peng, Yi, Bogden, Bert, Chen, Qian, Neuhausen, Susan, Shattuck-Eidens, Donna, Godwin, Andrew K, Daly, Mary, Radford, Diane M, Sedlacek, Scott, Rommens, Johanna, Simard, Jacques, Garber, Judy, Merajver, Sofia, Weber, Barbara L

“…The breast cancer susceptibility gene, BRCA2 on chromosome 13q12-13, was recently isolated. Mutations in BRCA2 are thought to account for as much as 35% of all…”
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Localization of BRCA1 and a splice variant identifies the nuclear localization signal by Thakur, Sanjay, Zhang, Hong Bing, Peng, Yi, Le, Huy, Carroll, Bryan, Ward, Theresa, Yao, Jie, Farid, Linda M., Couch, Fergus J., Wilson, Robert B., Weber, Barbara L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer by Castilla, Lucio H, Couch, Fergus J, Erdos, Michael R, Hoskins, Kent F, Calzone, Kathy, Garber, Judy E, Boyd, Jeff, Lubin, Matthew B, Deshano, Michelle L, Brody, Lawrence C, Collins, Francis S, Weber, Barbara L

“…We analysed 50 probands with a family history of breast and/or ovarian cancer for germline mutations in the coding region of the BRCA1 candidate gene, using…”
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Risk of Breast Cancer With Oral Contraceptive Use in Women With a Family History of Breast Cancer by Grabrick, Dawn M, Hartmann, Lynn C, Cerhan, James R, Vierkant, Robert A, Therneau, Terry M, Vachon, Celine M, Olson, Janet E, Couch, Fergus J, Anderson, Kristin E, Pankratz, V. Shane, Sellers, Thomas A

“…CONTEXT Oral contraceptive (OC) use is weakly associated with breast cancer risk in the general population, but the association among women with a familial…”
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Genetic heterogeneity in hereditary breast cancer : Role of BRCA1 and BRCA2 by REBBECK, T. R, COUCH, F. J, KANT, J, CALZONE, K, DESHANO, M, PENG, Y, CHEN, K, GARBER, J. E, WEBER, B. L

“…The common hereditary forms of breast cancer have been largely attributed to the inheritance of mutations in the BRCA1 or BRCA2 genes. However, it is not yet…”
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17q23 amplifications in breast cancer involve the PAT1, RAD51C, PS6K, and SIGMA1B genes by WU, Guo-Jun, SINCLAIR, Colleen S, PAAPE, John, INGLE, James N, ROCHE, Patrick C, JAMES, C. David, COUCH, Fergus J

“…Amplification of the 17q23 region occurs frequently in breast tumors. To characterize the structure of 17q23 amplicons and to identify oncogene targets…”
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Localization of PS6K to chromosomal region 17q23 and determination of its amplification in breast cancer by COUCH, F. J, WANG, X.-Y, WU, G.-J, JUNQI QIAN, JENKINS, R. B, JAMES, C. D

“…The application of comparative genomic hybridization to the analysis of genetic abnormalities in breast carcinoma has consistently revealed that chromosome…”
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