A comparison of three extrusion systems: part I: the influence of water content and extrusion speed on pellet properties
Multiparticulate oral dosage forms have gained considerable popularity since their market introduction because of their numerous pharmaceutical and technological advantages and their suitability for pediatric use. From a pharmaceutical point of view, pellets can reduce the variations in gastric drug...
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| Published in: | Pharmaceutical Technology Vol. 35; no. 1; p. 56 |
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| Main Authors: | , , , , |
| Format: | Magazine Article Trade Publication Article |
| Language: | English |
| Published: |
Monmouth Junction
MJH Life Sciences Media
01-01-2011
MultiMedia Healthcare Inc |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Multiparticulate oral dosage forms have gained considerable popularity since their market introduction because of their numerous pharmaceutical and technological advantages and their suitability for pediatric use. From a pharmaceutical point of view, pellets can reduce the variations in gastric drug levels, reduce inter- and intraindividual variations, minimize side effects and high local concentrations, and allow modified-release kinetics. Among the different methods to produce pellets, the process of extrusion-spheronization is of particular interest. Extrusion-spheronization is a semicontinuous process organized in five unit operations: blending, wet granulation, extrusion, spheronization, and drying. This process, fast and robust, limits the use of organic solvent and enables drug loading as high as 90%, depending on the active properties, in the mixture. In this context, studying the influence of water quantity and extrusion speed is an interesting way to highlight differences between extrusion systems. The design of experiments showed significant differences between the three extruders on all the responses studied. |
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| ISSN: | 1543-2521 2150-7376 |