Search Results - "Cotugno, Roberta"

The anti-tumor diterpene oridonin is a direct inhibitor of Nucleolin in cancer cells by Vasaturo, Michele, Cotugno, Roberta, Fiengo, Lorenzo, Vinegoni, Claudio, Dal Piaz, Fabrizio, De Tommasi, Nunziatina

“…The bioactive plant diterpene oridonin displays important pharmacological activities and is widely used in traditional Chinese medicine; however, its molecular…”
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Impairment of Nucleolin Activity and Phosphorylation by a Trachylobane Diterpene from Psiadia punctulata in Cancer Cells by Bellone, Maria Laura, Fiengo, Lorenzo, Cerchia, Carmen, Cotugno, Roberta, Bader, Ammar, Lavecchia, Antonio, De Tommasi, Nunziatina, Piaz, Fabrizio Dal

“…Human nucleolin (hNcl) is a multifunctional protein involved in the progression of various cancers and plays a key role in other pathologies. Therefore, there…”
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Genotype-Phenotype Correlation in a Family with Brugada Syndrome Harboring the Novel p.Gln371 Nonsense Variant in the SCN5A Gene by Monasky, Michelle M, Micaglio, Emanuele, Giachino, Daniela, Ciconte, Giuseppe, Giannelli, Luigi, Locati, Emanuela T, Ramondini, Elisa, Cotugno, Roberta, Vicedomini, Gabriele, Borrelli, Valeria, Ghiroldi, Andrea, Anastasia, Luigi, Pappone, Carlo

“…Brugada syndrome (BrS) is marked by coved ST-segment elevation and increased risk of sudden cardiac death. The genetics of this syndrome are elusive in over…”
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Properties of the endogenous components of the thioredoxin system in the psychrophilic eubacterium Pseudoalteromonas haloplanktis TAC 125 by Falasca, Patrizia, Evangelista, Giovanna, Cotugno, Roberta, Marco, Salvatore, Masullo, Mariorosario, De Vendittis, Emmanuele, Raimo, Gennaro

“…The endogenous components of the thioredoxin system in the Antarctic eubacterium Pseudoalteromonas haloplanktis have been purified and characterised. The…”
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Rat mitochondrial manganese superoxide dismutase: Amino acid positions involved in covalent modifications, activity, and heat stability by Castellano, Immacolata, Cecere, Francesca, De Vendittis, Alberto, Cotugno, Roberta, Chambery, Angela, Di Maro, Antimo, Michniewicz, Andzelika, Parlato, Giuseppe, Masullo, Mariorosario, Avvedimento, Enrico Vittorio, De Vendittis, Emmanuele, Ruocco, Maria Rosaria

“…The role of three amino acid residues (Q143, Y34, S82) of rat mitochondrial superoxide dismutase (ratSOD2) in the enzymatic activity, thermostability, and…”
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Adaptation of model proteins from cold to hot environments involves continuous and small adjustments of average parameters related to amino acid composition by De Vendittis, Emmanuele, Castellano, Immacolata, Cotugno, Roberta, Ruocco, Maria Rosaria, Raimo, Gennaro, Masullo, Mariorosario

“…The growth temperature adaptation of six model proteins has been studied in 42 microorganisms belonging to eubacterial and archaeal kingdoms, covering optimum…”
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Fusicoccane Diterpenes from Hypoestes forsskaolii as Heat Shock Protein 90 (Hsp90) Modulators by D’Ambola, Massimiliano, Fiengo, Lorenzo, Chini, Maria Giovanna, Cotugno, Roberta, Bader, Ammar, Bifulco, Giuseppe, Braca, Alessandra, De Tommasi, Nunziatina, Dal Piaz, Fabrizio

“…Ten new (1–10) and six known (11–16) fusicoccane diterpenes were isolated from the roots of Hypoestes forsskaolii. The structural characterization of 1–10 was…”
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New Constituents from Gymnocarpos decander by Bechlem, Houria, Mencherini, Teresa, Bouheroum, Mohamed, Benayache, Samir, Cotugno, Roberta, Braca, Alessandra, De Tommasi, Nunziatina

“…The phytochemical investigation of aerial parts extract afforded two new saponins, 3- - -D-glucuronopyranosyl-2 ,3 ,16 ,23-tetrahydroxyolean-12-en-28- -…”
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Phenolic Compounds from the Roots of Jordanian Viper’s Grass, Scorzonera judaica by Bader, Ammar, De Tommasi, Nunziatina, Cotugno, Roberta, Braca, Alessandra

“…Nine new phenolic compounds, 3S-hydrangenol 4′-O-α-l-rhamnopyranoysl-(1→3)-β-d-glucopyranoside (1), thunberginol F 7-O-β-d-glucopyranoside (2),…”
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A Chemical–Biological Study Reveals C 9 -type Iridoids as Novel Heat Shock Protein 90 (Hsp90) Inhibitors by Piaz, Fabrizio Dal, Vassallo, Antonio, Temraz, Abeer, Cotugno, Roberta, Belisario, Maria A., Bifulco, Giuseppe, Chini, Maria G., Pisano, Claudio, De Tommasi, Nunziatina, Braca, Alessandra

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BAG3 down-modulation sensitizes HPV18+ HeLa cells to PEITC-induced apoptosis and restores p53 by Cotugno, Roberta, Basile, Anna, Romano, Elena, Gallotta, Dario, Belisario, Maria Antonietta

“…Highlights • BAG3 down-modulation by siRNA technology restored p53. • Reduced BAG3 expression sensitized HeLa but not C33A (HPV-negative) cells to PEITC. •…”
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A Chemical–Biological Study Reveals C9‑type Iridoids as Novel Heat Shock Protein 90 (Hsp90) Inhibitors by Piaz, Fabrizio Dal, Vassallo, Antonio, Temraz, Abeer, Cotugno, Roberta, Belisario, Maria A, Bifulco, Giuseppe, Chini, Maria G, Pisano, Claudio, De Tommasi, Nunziatina, Braca, Alessandra

“…The potential of heat shock protein 90 (Hsp90) as a therapeutic target for numerous diseases has made the identification and optimization of novel Hsp90…”
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Chemical proteomics reveals HSP70 1A as a target for the anticancer diterpene oridonin in Jurkat cells by Dal Piaz, Fabrizio, Cotugno, Roberta, Lepore, Laura, Vassallo, Antonio, Malafronte, Nicola, Lauro, Gianluigi, Bifulco, Giuseppe, Belisario, Maria Antonietta, De Tommasi, Nunziatina

“…Oridonin, an ent-kaurane diterpene isolated from well known Chinese medicinal plant Isodon rubescens, has been shown to have multiple biological activities…”
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Antioxidant Potential of Herbal Preparations and Components from Galactites elegans (All.) Nyman ex Soldano by Vassallo, Antonio, D’Ambola, Massimiliano, Demirtas, Ibrahim, Bouheroum, Mohamed, Oke-Altuntas, Feyza, Cotugno, Roberta, Tebboub, Omar, Malafronte, Nicola

“…Galactites is a genus of flowering plants belonging to Asteraceae family. This genus is mainly represented by the Galactites elegans (All.) Nyman ex Soldano,…”
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Bioactive Limonoids from the Leaves of Azaridachta indica (Neem) by Gualtieri, Maria J, Malafronte, Nicola, Vassallo, Antonio, Braca, Alessandra, Cotugno, Roberta, Vasaturo, Michele, De Tommasi, Nunziatina, Dal Piaz, Fabrizio

“…Eight new limonoids (1–8) and one new phenol glycoside (9), along with six known compounds, were isolated from the leaves of Azaridachta indica. The structures…”
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SIRT1 Activity in Peripheral Blood Mononuclear Cells Correlates with Altered Lung Function in Patients with Chronic Obstructive Pulmonary Disease by Selleri, Carmine, Stellato, Cristiana, Filippelli, Amelia, Vatrella, Alessandro, Capaccio, Damiano, Cotugno, Roberta, Maglio, Angelantonio, Vitale, Carolina, Malangone, Paola, Manzo, V., Corbi, Graziamaria, Conti, V., Marino, Luigi

“…Background. Oxidative stress is a recognized pathogenic mechanism in chronic obstructive pulmonary disease (COPD). Expression of the NAD+-dependent deacetylase…”
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Cytotoxic triterpenes from Salvia buchananii roots by Beladjila, Khadidja Aya, Cotugno, Roberta, Berrehal, Djemaa, Kabouche, Zahia, De Tommasi, Nunziatina, Braca, Alessandra, De Leo, Marinella

“…A pentacyclic triterpene, named salvibuchanic acid (1), together with five known compounds, were isolated from the roots of Salvia buchananii Hedge…”
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Rimonabant-induced apoptosis in leukemia cell lines: Activation of caspase-dependent and -independent pathways by Gallotta, Dario, Nigro, Patrizia, Cotugno, Roberta, Gazzerro, Patrizia, Bifulco, Maurizio, Belisario, Maria Antonietta

“…Rimonabant (SR141716), a cannabinoid CB1 receptor antagonist known for anti-obesity activity, has more recently been shown to inhibit tumor cell growth. Here…”
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Diterpenes and phenylpropanoids from Clerodendrum splendens by Faiella, Laura, Temraz, Abeer, Cotugno, Roberta, De Tommasi, Nunziatina, Braca, Alessandra

“…Four new clerodane diterpenes (1-4) and one new phenylpropanoid (5) have been isolated from Clerodendrum splendens aerial parts, together with nine known…”
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Powerful tumor cell growth-inhibiting activity of a synthetic derivative of atractyligenin: Involvement of PI3K/Akt pathway and thioredoxin system by Cotugno, Roberta, Gallotta, Dario, Piaz, Fabrizio Dal, Apicella, Ivana, De Falco, Sandro, Rosselli, Sergio, Bruno, Maurizio, Belisario, Maria Antonietta

“…The semi-synthetic ent-kaurane 15-ketoatractyligenin methyl ester (SC2017) has been previously reported to possess high antiproliferative activity against…”
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