Search Results - "Cotton, Rachel N"

Four pathways of CD1 antigen presentation to T cells by Moody, D Branch, Cotton, Rachel N

“…•Human CD1a, CD1b, CD1c, and CD1d use distinct pathways for trafficking and antigen capture.•CD1a, CD1b and CD1c have inducible expression, yet upstream…”
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Lipids hide or step aside for CD1-autoreactive T cell receptors by Cotton, Rachel N, Shahine, Adam, Rossjohn, Jamie, Moody, D Branch

“…[Display omitted] •Human CD1-autoreactive T cells are common and can mediate autoimmunity.•T cell receptors can bind directly to CD1 without contacting bound…”
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Human skin is colonized by T cells that recognize CD1a independently of lipid by Cotton, Rachel N, Cheng, Tan-Yun, Wegrecki, Marcin, Le Nours, Jérôme, Orgill, Dennis P, Pomahac, Bohdan, Talbot, Simon G, Willis, Richard A, Altman, John D, de Jong, Annemieke, Ogg, Graham, Van Rhijn, Ildiko, Rossjohn, Jamie, Clark, Rachael A, Moody, D Branch

“…CD1a-autoreactive T cells contribute to skin disease, but the identity of immunodominant self-lipid antigens and their mode of recognition are not yet solved…”
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CD1a selectively captures endogenous cellular lipids that broadly block T cell response by Cotton, Rachel N, Wegrecki, Marcin, Cheng, Tan-Yun, Chen, Yi-Ling, Veerapen, Natacha, Le Nours, Jérôme, Orgill, Dennis P, Pomahac, Bohdan, Talbot, Simon G, Willis, Richard, Altman, John D, de Jong, Annemieke, Van Rhijn, Ildiko, Clark, Rachael A, Besra, Gurdyal S, Ogg, Graham, Rossjohn, Jamie, Moody, D Branch

“…We optimized lipidomics methods to broadly detect endogenous lipids bound to cellular CD1a proteins. Whereas membrane phospholipids dominate in cells, CD1a…”
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Mycobacterium tuberculosis releases an antacid that remodels phagosomes by Buter, Jeffrey, Cheng, Tan-Yun, Ghanem, Marwan, Grootemaat, Anita E., Raman, Sahadevan, Feng, Xinxin, Plantijn, Ashmir R., Ennis, Thomas, Wang, Joyce, Cotton, Rachel N., Layre, Emilie, Ramnarine, Alexandrea K., Mayfield, Jacob A., Young, David C., Jezek Martinot, Amanda, Siddiqi, Noman, Wakabayashi, Shoko, Botella, Helene, Calderon, Roger, Murray, Megan, Ehrt, Sabine, Snider, Barry B., Reed, Michael B., Oldfield, Eric, Tan, Shumin, Rubin, Eric J., Behr, Marcel A., van der Wel, Nicole N., Minnaard, Adriaan J., Moody, D. Branch

“…Mycobacterium tuberculosis ( Mtb ) is the world’s most deadly pathogen. Unlike less virulent mycobacteria, Mtb produces 1-tuberculosinyladenosine (1-TbAd), an…”
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Microfilariae of Brugia malayi Inhibit the mTOR Pathway and Induce Autophagy in Human Dendritic Cells by Narasimhan, Prakash Babu, Bennuru, Sasisekhar, Meng, Zhaojing, Cotton, Rachel N, Elliott, Kathleen R, Ganesan, Sundar, McDonald-Fleming, Renee, Veenstra, Timothy D, Nutman, Thomas B, Tolouei Semnani, Roshanak

“…Immune modulation is a hallmark of patent filarial infection, including suppression of antigen-presenting cell function and downmodulation of filarial…”
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Human dendritic cells exhibit a pronounced type I IFN signature following Leishmania major infection that is required for IL-12 induction by Favila, Michelle A, Geraci, Nicholas S, Zeng, Erliang, Harker, Brent, Condon, David, Cotton, Rachel N, Jayakumar, Asha, Tripathi, Vinita, McDowell, Mary Ann

“…Leishmania major-infected human dendritic cells (DCs) exhibit a marked induction of IL-12, ultimately promoting a robust Th1-mediated response associated with…”
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Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products by Nicolai, Sarah, Wegrecki, Marcin, Cheng, Tan-Yun, Bourgeois, Elvire A, Cotton, Rachel N, Mayfield, Jacob A, Monnot, Gwennaëlle C, Le Nours, Jérôme, Van Rhijn, Ildiko, Rossjohn, Jamie, Moody, D Branch, de Jong, Annemieke

“…During industrialization, humans have been exposed to increasing numbers of foreign chemicals. Failure of the immune system to tolerate drugs, cosmetics, and…”
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Total Synthesis of Mycobacterium tuberculosis Dideoxymycobactin‐838 and Stereoisomers: Diverse CD1a‐Restricted T Cells Display a Common Hierarchy of Lipopeptide Recognition by Cheng, Janice M. H., Liu, Ligong, Pellicci, Daniel G., Reddiex, Scott J. J., Cotton, Rachel N., Cheng, Tan‐Yun, Young, David C., Van Rhijn, Ildiko, Moody, D. Branch, Rossjohn, Jamie, Fairlie, David P., Godfrey, Dale I., Williams, Spencer J.

“…Mycobacterium tuberculosis produces dideoxymycobactin‐838 (DDM‐838), a lipopeptide that potently activates T cells upon binding to the MHC‐like…”
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Human Dendritic Cells exhibit a pronounced type I IFN signature following Leishmania major infection that is required for IL-12 induction1 by Favila, Michelle A., Geraci, Nicholas S., Zeng, Erliang, Harker, Brent, Condon, David, Cotton, Rachel N., Jayakumar, Asha, Tripathi, Vinita, McDowell, Mary Ann

“…Leishmania major infected human dendritic cells (DCs) exhibit a marked induction of IL-12, ultimately promoting a robust Th1-mediated response associated with…”
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Leishmania major inhibits IL-12 in macrophages by signaling through CR3 (CD11b/CD18) and downregulation of ETS-mediated transcription by Ricardo-Carter, Cristina, Favila, Michelle, Polando, Rachel E., Cotton, Rachel N., Horner, Kimberly Bogard, Condon, David, Ballhorn, Wibke, Whitcomb, James P., Yadav, Mahesh, Geister, Rebecca L., Schorey, Jeffery S., McDowell, Mary Ann

“…Leishmania major is an etiological agent of cutaneous leishmaniasis. The parasite primarily infects immune sentinel cells, specifically macrophages and…”
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