Search Results - "Cottom, Josh"

Waste management needs a data revolution – Is plastic pollution an opportunity? by Velis, Costas A, Cook, Ed, Cottom, Josh

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Identification and Optimization of Novel Small c‑Abl Kinase Activators Using Fragment and HTS Methodologies by Simpson, Graham L, Bertrand, Sophie M, Borthwick, Jennifer A, Campobasso, Nino, Chabanet, Julien, Chen, Susan, Coggins, Julia, Cottom, Josh, Christensen, Siegfried B, Dawson, Helen C, Evans, Helen L, Hobbs, Andrew N, Hong, Xuan, Mangatt, Biju, Munoz-Muriedas, Jordi, Oliff, Allen, Qin, Donghui, Scott-Stevens, Paul, Ward, Paris, Washio, Yoshiaki, Yang, Jingsong, Young, Robert J

“…Abelson kinase (c-Abl) is a ubiquitously expressed, nonreceptor tyrosine kinase which plays a key role in cell differentiation and survival. It was…”
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Abstract 6590: Novel WRN helicase inhibitors selectively target microsatellite unstable cancer cells by Picco, Gabriele, Rao, Yanhua, Al Saedi, Angham, Vieira, Sara F., Lee, Yang, Shenje, Ray, Bhosle, Shriram, Walker, Samantha, May, Kieron, Herranz-Ors, Carmen, Dicer, Cansu, Gibson, Freddy, Banerjee, Ruby, Werner, Thilo, Cottom, Josh, Peng, Yang, Deng, Nanhua, Landis, Phil, Angel, Thomas, Bush, Jacob, Rees, Matthew G., Ronan, Melissa M., Roth, Jennifer A., Lightfoot, Howard, Zappacosta, Francesca, Pettinger, Jonathan, Barthorpe, Syd, Eberl, Chris, Jones, Brian, Schneck, Jess, Murphy, Dennis, Taygerly, Josh, DeMartino, Mike, Coelho, Matthew, Houseley, Jon, Schwartz, Benjamin, Garnett, Mathew J.

“…Microsatellite-unstable (MSI) cancers depend on the WRN helicase to resolve replication stress from expanded (TA)-dinucleotide repeats. WRN is a promising…”
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Abstract 1628: A small-molecule inhibitor of WRN selectively kills MSI-H cancer cells and phenocopies WRN genetic defects by Rao, Yanhua, Srivatsan, Anjana, Liimatta, Marya, Munoz, Diana, Quirit, Jeanne, Shi, Jianxia, Nguyen, An, Linghu, Xin, Federowicz, Federowicz, Jones, Brian, Fleury, Melissa, Newby, Zach, Dillon, Michael P., Barsanti, Paul A., Lackner, Mark R., White, Michael A., Lee, Yang, Landis, Phil, Peng, Yang, Cicchini, Michelle, Cottom, Josh, Nickels, Leng, Brnardic, Ed, DeMartino, Michael, Taygerly, Josh

“…Werner syndrome protein (WRN) is a RecQ-family helicase involved in the maintenance of genome integrity. Germline mutations in WRN cause premature aging and…”
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Structure-guided optimization of small molecule c-Abl activators by Hong, Xuan, Cao, Ping, Washio, Yoshiaki, Simpson, Graham, Campobasso, Nino, Yang, Jingsong, Borthwick, Jennifer, Burton, George, Chabanet, Julien, Bertrand, Sophie, Evans, Helen, Young, Robert J., Qu, Junya, Li, Hu, Cottom, Josh, Ward, Paris, Zhang, Hong, Ho, Thau, Qin, Donghui, Christensen, Siegfried, Head, Martha S.

“…c-Abl kinase is maintained in its normal inactive state in the cell through an assembled, compact conformation. We describe two chemical series that bind to…”
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2-Phenyl-4-piperazinylbenzimidazoles: Orally active inhibitors of the gonadotropin releasing hormone (GnRH) receptor by Pelletier, Jeffrey C., Chengalvala, Murty, Cottom, Josh, Feingold, Irene, Garrick, Lloyd, Green, Daniel, Hauze, Diane, Huselton, Christine, Jetter, James, Kao, Wenling, Kopf, Gregory S., Lundquist, Joseph T., Mann, Charles, Mehlmann, John, Rogers, John, Shanno, Linda, Wrobel, Jay

“…Antagonism of the gonadotropin releasing hormone (GnRH) receptor has shown positive clinical results in numerous reproductive tissue disorders such as…”
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Assay development and high-throughput screening of small molecular c-Abl kinase activators by Cottom, Josh, Hofmann, Glenn, Siegfried, Brett, Yang, Jingsong, Zhang, Hong, Yi, Tracey, Ho, Thau F, Quinn, Chad, Wang, Da-Yuan, Johanson, Kyung, Ames, Robert S, Li, Hu

“…A 2-step kinase assay was developed and used in a high-throughput screen (HTS) of more than 1 million compounds in an effort to identify c-Abl tyrosine kinase…”
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Discovery and Characterization of a Cell-Permeable, Small-Molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site by Yang, Jingsong, Campobasso, Nino, Biju, Mangatt P., Fisher, Kelly, Pan, Xiao-Qing, Cottom, Josh, Galbraith, Sarah, Ho, Thau, Zhang, Hong, Hong, Xuan, Ward, Paris, Hofmann, Glenn, Siegfried, Brett, Zappacosta, Francesca, Washio, Yoshiaki, Cao, Ping, Qu, Junya, Bertrand, Sophie, Wang, Da-Yuan, Head, Martha S., Li, Hu, Moores, Sheri, Lai, Zhihong, Johanson, Kyung, Burton, George, Erickson-Miller, Connie, Simpson, Graham, Tummino, Peter, Copeland, Robert A., Oliff, Allen

“…c-Abl kinase activity is regulated by a unique mechanism involving the formation of an autoinhibited conformation in which the N-terminal myristoyl group binds…”
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